Indirubin-3′-monoxime induces paraptosis in MDA-MB-231 breast cancer cells by transmitting Ca2+ from endoplasmic reticulum to mitochondria

Death Receptor Interactions With the Mitochondrial Cell Death Pathway During Immune Cell-, Drug- and Toxin-Induced Liver Damage

(2019) Valentina Spinnenhirn et al.   Frontiers in Cell and Developmental Biology

p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression

(2019) Matharage Gayani Dilshara et al.   Antioxidants

Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models

(2018) Kyu-Sun Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma

(2018) V. Desantis et al.   Translational Oncology

Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme

(2017) Lin Wang et al.   Cell Death & Disease

Regulation of Endoplasmic Reticulum–Mitochondria Ca2+ Transfer and Its Importance for Anti-Cancer Therapies

(2017) Gaia Pedriali et al.   Frontiers in Oncology

Paraptosis in the anti-cancer arsenal of natural products

(2016) Dongjoo Lee et al.   PHARMACOLOGY & THERAPEUTICS

Cytoplasmic vacuolization in cell death and survival

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Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red

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5-Nitro-5′-hydroxy-indirubin-3′-oxime (AGM130), an indirubin-3′-oxime derivative, inhibits tumor growth by inducing apoptosis against non-small cell lung cancer in vitro and in vivo

(2015) Mee-Young Ahn et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases

(2015) Tina Blažević et al.   Evidence-based Complementary and Alternative Medicine

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer

(2014) Simone Braig et al.   BIOCHEMICAL PHARMACOLOGY

Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin

(2014) M J Yoon et al.   Cell Death & Disease

Indirubin-3′-monoxime promotes autophagic and apoptotic death in JM1 human acute lymphoblastic leukemia cells and K562 human chronic myelogenous leukemia cells

(2013) MING-YANG LEE et al.   ONCOLOGY REPORTS

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells

(2012) Katerina A. Nicolaou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

(2012) Mi Jin Yoon et al.   CANCER LETTERS

Mitochondrial Ca2+ and apoptosis

(2012) Carlotta Giorgi et al.   CELL CALCIUM

Identification of new modulators and protein alterations in non-apoptotic programmed cell death

(2010) Sabina Sperandio et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Indirubin derivatives inhibit malignant lymphoid cell proliferation

(2010) Amel Chebel et al.   LEUKEMIA & LYMPHOMA

Indirubin-3′-oxime prevents hepatic I/R damage by inhibiting GSK-3β and mitochondrial permeability transition

(2010) Ana T. Varela et al.   MITOCHONDRION

Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells

(2009) Mi Jin Yoon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ca2+ Signaling, Mitochondria and Cell Death

(2008) Paolo Pinton et al.   CURRENT MOLECULAR MEDICINE

Tumor resistance to apoptosis

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF CANCER