pH-Sensitive Polymeric Nanoparticles Modulate Autophagic Effect via Lysosome Impairment

Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo

(2015) Yi Wang et al.   ADVANCED MATERIALS

Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A549 lung cancer cells using redox-responsive nanohybrids: A new strategy for cancer therapy

(2015) Hsin-Yi Lu et al.   BIOMATERIALS

Control of polymeric nanoparticle size to improve therapeutic delivery

(2015) John W. Hickey et al.   JOURNAL OF CONTROLLED RELEASE

pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy

(2015) Yao-Xin Lin et al.   MOLECULAR PHARMACEUTICS

Improved autophagic flux is correlated with mTOR activation in the later recovery stage of experimental acute pancreatitis

(2015) Yang-Yang Hu et al.   PANCREATOLOGY

High content analysis at single cell level identifies different cellular responses dependent on nanomaterial concentrations

(2015) Bella B. Manshian et al.   Scientific Reports

Self-assembly of cytotoxic peptide conjugated poly(β-amino ester)s for synergistic cancer chemotherapy

(2015) Zeng-Ying Qiao et al.   Journal of Materials Chemistry B

Nanoparticles modulate autophagic effect in a dispersity-dependent manner

(2015) Dengtong Huang et al.   Scientific Reports

Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry

(2014) Ling Wu et al.   ACS Nano

Bioactive Silica Nanoparticles Promote Osteoblast Differentiation through Stimulation of Autophagy and Direct Association with LC3 and p62

(2014) Shin-Woo Ha et al.   ACS Nano

Ceria Nanoparticles Stabilized by Organic Surface Coatings Activate the Lysosome-Autophagy System and Enhance Autophagic Clearance

(2014) Wensi Song et al.   ACS Nano

Role for nanomaterial-autophagy interaction in neurodegenerative disease

(2014) Stephan T. Stern et al.   Autophagy

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

Asymmetrical Polymer Vesicles with a “Stealthy” Outer Corona and an Endosomal-Escape-Accelerating Inner Corona for Efficient Intracellular Anticancer Drug Delivery

(2014) Qiuming Liu et al.   BIOMACROMOLECULES

The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug

(2014) Xudong Zhang et al.   BIOMATERIALS

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

(2014) Yu-Hsuan Lee et al.   BIOMATERIALS

The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers

(2014) Shaofei Wang et al.   BIOMATERIALS

Exploiting Intrinsic Nanoparticle Toxicity: The Pros and Cons of Nanoparticle-Induced Autophagy in Biomedical Research

(2014) Karen Peynshaert et al.   CHEMICAL REVIEWS

Evaluation of acridine orange, LysoTracker Red, and quinacrine as fluorescent probes for long-term tracking of acidic vesicles

(2014) Agnieszka Pierzyńska-Mach et al.   CYTOMETRY PART A

Nanomaterial-Induced Autophagy: A New Reversal MDR Tool in Cancer Therapy?

(2014) Elisa Panzarini et al.   MOLECULAR PHARMACEUTICS

Nanoparticle assembly: Building blocks for tumour delivery

(2014) Hak Soo Choi   Nature Nanotechnology

Intracellular Drug Delivery: Smart Nanovehicles Based on pH-Triggered Disassembly of Supramolecular Peptide-Amphiphiles for Efficient Intracellular Drug Delivery (Small 6/2014)

(2014) Xianghui Xu et al.   Small

A photoacoustic approach for monitoring the drug release of pH-sensitive poly(β-amino ester)s

(2014) Zhongyu Duan et al.   Journal of Materials Chemistry B

Autophagy as a Possible Underlying Mechanism of Nanomaterial Toxicity

(2014) Vanessa Cohignac et al.   Nanomaterials

Chitosan-Based Nanocarriers with pH and Light Dual Response for Anticancer Drug Delivery

(2013) Lili Meng et al.   BIOMACROMOLECULES

Polymersomes from Dual Responsive Block Copolymers: Drug Encapsulation by Heating and Acid-Triggered Release

(2013) Zeng-Ying Qiao et al.   BIOMACROMOLECULES

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Toward Tertiary Amine-Modulated Acid-Triggered Hydrolysis of Copolymers Containing Pendent Ortho Ester Groups

(2013) Cheng-Cheng Song et al.   MACROMOLECULES

A suppression switch

(2013) Hanna Starobinets et al.   NATURE

One-pot synthesis of pH-sensitive poly(RGD-co-β-amino ester)s for targeted intracellular drug delivery

(2013) Zeng-Ying Qiao et al.   Polymer Chemistry

Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy

(2013) Akiko Eguchi et al.   Adipocyte

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dopamine-Modified Cationic Conjugated Polymer as a New Platform for pH Sensing and Autophagy Imaging

(2012) Quanshan Wen et al.   ADVANCED FUNCTIONAL MATERIALS

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycerol for pH-Responsive Drug Delivery

(2012) Sueun Lee et al.   BIOMACROMOLECULES

The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

(2012) Wenchuan She et al.   BIOMATERIALS

Tunable pH-Sensitive Poly(β-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery

(2012) Wantong Song et al.   MACROMOLECULAR BIOSCIENCE

Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides

(2012) Yunjiao Zhang et al.   NATURE MATERIALS

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells

(2012) Tingting Sun et al.   PLoS One

Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment

(2011) Xiaowei Ma et al.   ACS Nano

A Smart Polysaccharide/Drug Conjugate for Photodynamic Therapy

(2011) So Young Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs

(2011) Zeng-Ying Qiao et al.   JOURNAL OF CONTROLLED RELEASE

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

(2011) Tore-Geir Iversen et al.   Nano Today

Autophagy and oxidative stress associated with gold nanoparticles

(2010) Jasmine J. Li et al.   BIOMATERIALS

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Tumoral acidic pH-responsive MPEG-poly(β-amino ester) polymeric micelles for cancer targeting therapy

(2010) Kyung Hyun Min et al.   JOURNAL OF CONTROLLED RELEASE

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Biocompatible Thermoresponsive Polymers with Pendent Oligo(ethylene glycol) Chains and Cyclic Ortho Ester Groups

(2010) Zeng-Ying Qiao et al.   MACROMOLECULES

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Mixed pH-Sensitive Polymeric Micelles for Combination Drug Delivery

(2010) Younsoo Bae et al.   PHARMACEUTICAL RESEARCH

Lysosomal Storage Disease: Revealing Lysosomal Function and Physiology

(2010) Emma J. Parkinson-Lawrence et al.   PHYSIOLOGY

Polymer−Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery

(2009) Santosh Aryal et al.   ACS Nano

Temperature- and pH-Sensitive Multicolored Micellar Complexes

(2009) Yong-Yong Li et al.   ADVANCED MATERIALS

Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal

(2009) Qiang Zhang et al.   Autophagy

Nanocarriers’ entry into the cell: relevance to drug delivery

(2009) Hervé Hillaireau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles

(2009) Wei Chen et al.   JOURNAL OF CONTROLLED RELEASE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rare Earth Oxide Nanocrystals Induce Autophagy in HeLa Cells

(2009) Le Yu et al.   Small

PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway

(2009) C. Li et al.   Journal of Molecular Cell Biology

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

(2008) P. Chytil et al.   JOURNAL OF CONTROLLED RELEASE

Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications

(2008) Eric M. Bachelder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Autophagy in Porcine Kidney Cells by Quantum Dots: A Common Cellular Response to Nanomaterials?

(2008) Stephan T. Stern et al.   TOXICOLOGICAL SCIENCES

Physicochemical characteristics of pH-sensitive poly(l-Histidine)-b-poly(ethylene glycol)/poly(l-Lactide)-b-poly(ethylene glycol) mixed micelles

(2007) Haiqing Yin et al.   JOURNAL OF CONTROLLED RELEASE