FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

The role of autophagy in resistance to targeted therapies

(2020) Luigi Mele et al.   CANCER TREATMENT REVIEWS

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Inflammasomes, Neutrophil Extracellular Traps, and Cholesterol

(2019) Alan R. Tall et al.   JOURNAL OF LIPID RESEARCH

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production

(2019) Ruifang Wang et al.   Autophagy

Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma

(2019) Kok-Tong Tan et al.   ANTI-CANCER DRUGS

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(2019) Yitao Gong et al.   Molecular Cancer

Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM

(2019) Xia Cheng et al.   Breast Cancer

Lysosome Inhibition by Mefloquine Preferentially Enhances the Cytotoxic Effects of Tyrosine Kinase Inhibitors in Blast Phase Chronic Myeloid Leukemia

(2019) Hui Lam Yi et al.   Translational Oncology

Involvement of Actin in Autophagy and Autophagy-Dependent Multidrug Resistance in Cancer

(2019) Magdalena Izdebska et al.   Cancers

Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9

(2019) Hui Li et al.   ARCHIVES OF TOXICOLOGY

Lys05 induces lysosomal membrane permeabilization and increases radiosensitivity in glioblastoma

(2019) Wei Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Chaperone-Mediated Autophagy and Its Emerging Role in Hematological Malignancies

(2019) Guillaume Robert et al.   Cells

Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions

(2019) Lauren C. Fleischer et al.   Journal of Hematology & Oncology

AEG-1 is involved in hypoxia-induced autophagy and decreases chemosensitivity in T-cell lymphoma

(2018) Jiaqin Yan et al.   MOLECULAR MEDICINE

Rab GTPase Function in Endosome and Lysosome Biogenesis

(2018) Lars Langemeyer et al.   TRENDS IN CELL BIOLOGY

Influence of c-Src on hypoxic resistance to paclitaxel in human ovarian cancer cells and reversal of FV-429

(2018) Qinglong Guo et al.   Cell Death & Disease

Lysosomes contribute to radioresistance in cancer

(2018) Xin Zhang et al.   CANCER LETTERS

Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy

(2018) Antoni Domagala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Duck enteritis virus activates CaMKKβ-AMPK to trigger autophagy in duck embryo fibroblast cells via increased cytosolic calcium

(2018) Haichang Yin et al.   Virology Journal

Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells

(2018) Tae Woo Kim et al.   Cell Death & Disease

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells

(2018) Xiaoqing Dong et al.   CELLULAR SIGNALLING

Autophagy and intermittent fasting: the connection for cancer therapy?

(2018) F Antunes et al.   Clinics

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

(2018) Marion Alcantara et al.   LEUKEMIA

Apatinib-induced protective autophagy and apoptosis through the AKT–mTOR pathway in anaplastic thyroid cancer

(2018) Haoran Feng et al.   Cell Death & Disease

N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease

(2017) Patricia García-Sanz et al.   MOVEMENT DISORDERS

Combination of wogonin and sorafenib effectively kills human hepatocellular carcinoma cells through apoptosis potentiation and autophagy inhibition

(2017) Li-Wen Rong et al.   Oncology Letters

The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling

(2017) Zhao Cheng et al.   Oncotarget

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

(2016) Zhenyu Cai et al.   CELL RESEARCH

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

LZ-106, a novel analog of enoxacin, inducing apoptosis via activation of ROS-dependent DNA damage response in NSCLCs

(2016) Lin Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipids, lysosomes, and autophagy

(2016) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells

(2016) Shao-Jun Li et al.   Oncology Letters

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

(2015) Yu Matsuzawa et al.   Autophagy

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

Activation of autophagy via Ca2+-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress

(2015) Li-Bo Jiang et al.   CELL CYCLE

FV-429 Induced Apoptosis Through ROS-Mediated ERK2 Nuclear Translocation and p53 Activation in Gastric Cancer Cells

(2015) Yuxin Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism

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FV-429 induces apoptosis and inhibits glycolysis by inhibiting Akt-mediated phosphorylation of hexokinase II in MDA-MB-231 cells

(2015) Yuxin Zhou et al.   MOLECULAR CARCINOGENESIS

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

(2015) Daniel Herranz et al.   NATURE MEDICINE

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

(2014) E Gabandé-Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Lysosome: the cell's ‘suicidal bag’ as a promising cancer target

(2014) Melina-Theoni Gyparaki et al.   TRENDS IN MOLECULAR MEDICINE

Cytoprotective and nonprotective autophagy in cancer therapy

(2013) David A. Gewirtz   Autophagy

Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells

(2013) Magali Humbert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells

(2012) Shu-Er Chow et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

(2012) Mahadeo A. Sukhai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer-associated lysosomal changes: friends or foes?

(2012) T Kallunki et al.   ONCOGENE

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Reactive oxygen species–mitochondria pathway involved in FV-429-induced apoptosis in human hepatocellular carcinoma HepG2 cells

(2011) Zhen Yang et al.   ANTI-CANCER DRUGS

Lysosomes and lysosomal cathepsins in cell death

(2011) Urška Repnik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases

(2011) Emyr Lloyd-Evans et al.   CELL CALCIUM

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling

(2011) Sung Min Son et al.   NEUROBIOLOGY OF AGING

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Chaperone-mediated autophagy in health and disease

(2009) Maria Kon et al.   FEBS LETTERS

Caspase-independent cell death: leaving the set without the final cut

(2008) S W G Tait et al.   ONCOGENE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE