Targeting nucleic acid-based therapeutics to tumors: Challenges and strategies for polyplexes
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting nucleic acid-based therapeutics to tumors: Challenges and strategies for polyplexes
Authors
Keywords
Cancer, Nanoparticle, pDNA, Polyplex, siRNA, Targeting
Journal
JOURNAL OF CONTROLLED RELEASE
Volume 346, Issue -, Pages 110-135
Publisher
Elsevier BV
Online
2022-04-22
DOI
10.1016/j.jconrel.2022.04.013
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP
- (2022) Yi Lin et al. Biomaterials Science
- Nanoparticle-based delivery strategies of multifaceted immunomodulatory RNA for cancer immunotherapy
- (2022) Yeon Jeong Yoo et al. JOURNAL OF CONTROLLED RELEASE
- The growth of siRNA-based therapeutics: updated clinical studies
- (2021) M. May Zhang et al. BIOCHEMICAL PHARMACOLOGY
- Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic
- (2021) Annette I.S. van den Berg et al. JOURNAL OF CONTROLLED RELEASE
- Hyaluronic acid (HA)-coated naproxen-nanoparticles selectively target breast cancer stem cells through COX-independent pathways
- (2021) Eva Espinosa-Cano et al. Materials Science & Engineering C-Materials for Biological Applications
- Polymeric Delivery of Therapeutic Nucleic Acids
- (2021) Ramya Kumar et al. CHEMICAL REVIEWS
- mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
- (2021) Linde Schoenmaker et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain
- (2021) Saed Abbasi et al. JOURNAL OF CONTROLLED RELEASE
- Charge-reversal nanocomolexes-based CRISPR/Cas9 delivery system for loss-of-function oncogene editing in hepatocellular carcinoma
- (2021) Jing-Jun Nie et al. JOURNAL OF CONTROLLED RELEASE
- Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy
- (2021) Tzu-Chieh Ho et al. Science Advances
- The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery—Personal Remarks and Future Prospects
- (2021) Hiroshi Maeda Journal of Personalized Medicine
- Engineering Nanorobots for Tumor‐Targeting Drug Delivery: From Dynamic Control to Stimuli‐Responsive Strategy
- (2021) Lujia Huang et al. CHEMBIOCHEM
- Nanomedicines functionalized with anti-EGFR ligands for active targeting in cancer therapy: Biological strategy, design and quality control
- (2021) Phuoc Vinh Nguyen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA
- (2021) Shuang Liu et al. MOLECULES
- BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans
- (2021) Ugur Sahin et al. NATURE
- CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
- (2021) Julian D. Gillmore et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy of Targeted ECO/miR-200c Nanoparticles for Modulating Tumor Microenvironment and Treating Triple Negative Breast Cancer as Non-invasively Monitored by MR Molecular Imaging
- (2021) Andrew L. Schilb et al. PHARMACEUTICAL RESEARCH
- Vascular Bursts Act as a Versatile Tumor Vessel Permeation Route for Blood‐Borne Particles and Cells
- (2021) Kazunori Igarashi et al. Small
- Two Antibody-Guided Lactic-co-Glycolic Acid-Polyethylenimine (LGA-PEI) Nanoparticle Delivery Systems for Therapeutic Nucleic Acids
- (2021) Jian-Ming Lü et al. Pharmaceuticals
- Transferrin Receptor Targeted Polyplexes Completely Comprised of Sequence‐Defined Components
- (2021) Teoman Benli‐Hoppe et al. MACROMOLECULAR RAPID COMMUNICATIONS
- Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes
- (2021) Rebekka Spellerberg et al. Molecular Therapy-Oncolytics
- Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Coated Polymeric Nanocarrier
- (2020) Hyun Su Min et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Folate-Mediated Targeted Delivery of siPLK1 by Leucine-Bearing Polyethylenimine
- (2020) Lu Hou et al. International Journal of Nanomedicine
- The entry of nanoparticles into solid tumours
- (2020) Shrey Sindhwani et al. NATURE MATERIALS
- Double Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells
- (2020) Yanfang Wang et al. ACS Biomaterials-Science & Engineering
- The solid progress of nanomedicine
- (2020) João Pedro Martins et al. Drug Delivery and Translational Research
- Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy
- (2020) Xiangrong Song et al. ADVANCED DRUG DELIVERY REVIEWS
- Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment
- (2020) Yan Zou et al. ADVANCED MATERIALS
- Silencing of IL-6 and STAT3 by siRNA loaded hyaluronate-N,N,N-trimethyl chitosan nanoparticles potently reduces cancer cell progression
- (2020) Ali Masjedi et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- A nanoparticle’s pathway into tumours
- (2020) Irene de Lázaro et al. NATURE MATERIALS
- Active transcytosis and new opportunities for cancer nanomedicine
- (2020) Subehndu Pandit et al. NATURE MATERIALS
- Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
- (2020) Alexandre J. Debacker et al. MOLECULAR THERAPY
- Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy
- (2020) Francesco Mainini et al. MOLECULES
- Endothelial Cell Targeting by cRGD-Functionalized Polymeric Nanoparticles under Static and Flow Conditions
- (2020) Lucía Martínez-Jothar et al. Nanomaterials
- Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors
- (2020) Evgenii Belykh et al. Frontiers in Oncology
- The role of CD44 in pathological angiogenesis
- (2020) Li Chen et al. FASEB JOURNAL
- A Novel Therapeutic siRNA Nanoparticle Designed for Dual-Targeting CD44 and Gli1 of Gastric Cancer Stem Cells
- (2020) Hongjuan Yao et al. International Journal of Nanomedicine
- Hyaluronate siRNA nanoparticles with positive charge display rapid attachment to tumor endothelium and penetration into tumors
- (2020) Jie Luo et al. JOURNAL OF CONTROLLED RELEASE
- Efficient LRP1-Mediated Uptake and Low Cytotoxicity of Peptide L57 In Vitro Shows Its Promise as CNS Drug Delivery Vector
- (2020) Jolin P. Rodrigues et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines
- (2020) Julio M. Rios De La Rosa et al. Scientific Reports
- Aptamer-Functionalized Dendrimer Delivery of Plasmid-Encoding lncRNA MEG3 Enhances Gene Therapy in Castration-Resistant Prostate Cancer
- (2020) Zongguang Tai et al. International Journal of Nanomedicine
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Peptide Gene Delivery Vectors for Specific Transfection of Glioma Cells
- (2020) Taoran Wang et al. ACS Biomaterials-Science & Engineering
- Polyethyleneimine-polyethylene glycol copolymer targeted by anti-HER2 nanobody for specific delivery of transcriptionally targeted tBid containing construct
- (2019) Batoul Saqafi et al. Artificial Cells Nanomedicine and Biotechnology
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- Cell Permeable NBD Peptide-Modified Liposomes by Hyaluronic Acid Coating for the Synergistic Targeted Therapy of Metastatic Inflammatory Breast Cancer
- (2019) Yuqing Sun et al. MOLECULAR PHARMACEUTICS
- Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression
- (2019) Sarah Urnauer et al. GENE THERAPY
- Local delivery of OX40L, CD80, and CD86 mRNA kindles global anti-cancer immunity.
- (2019) Ole Audun Werner Haabeth et al. CANCER RESEARCH
- Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy
- (2019) Amita M Vaidya et al. BIOCONJUGATE CHEMISTRY
- Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo
- (2019) Min Wang et al. BIOMATERIALS
- Non‐viral gene delivery for cancer immunotherapy
- (2019) Weiqi Wang et al. JOURNAL OF GENE MEDICINE
- MRNA Delivery For Therapeutic Anti-Her2 Antibody Expression In Vivo
- (2019) Yulia Rybakova et al. MOLECULAR THERAPY
- Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems
- (2019) Jihye Yoo et al. Cancers
- ROS‐Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy
- (2019) Meng Zheng et al. ADVANCED MATERIALS
- Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
- (2019) Quan Zhou et al. Nature Nanotechnology
- Tailor-made ternary nanopolyplexes of thiolated trimethylated chitosan with pDNA and folate conjugated cis-aconitic amide-polyethylenimine for efficient gene delivery
- (2019) Qing Liu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells
- (2019) Ines Truebenbach et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- NanoRNP Overcomes Tumor Heterogeneity in Cancer Treatment
- (2019) Qi Liu et al. NANO LETTERS
- Transcytosis of Nanomedicine for Tumor Penetration
- (2019) Yan Liu et al. NANO LETTERS
- Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumours
- (2018) Qin Dai et al. ACS Nano
- Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo
- (2018) Philipp Michael Klein et al. BIOMATERIALS
- Block Copolymer Micelles in Nanomedicine Applications
- (2018) Horacio Cabral et al. CHEMICAL REVIEWS
- Highly efficacious and specific anti-glioma chemotherapy by tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides
- (2018) Yaqin Zhu et al. JOURNAL OF CONTROLLED RELEASE
- Epidermal growth factor receptor targeted methotrexate and small interfering RNA co-delivery
- (2018) Benjamin Steinborn et al. JOURNAL OF GENE MEDICINE
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
- (2018) David Adams et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cell-penetrating peptides for siRNA delivery to glioblastomas
- (2018) Artita Srimanee et al. PEPTIDES
- Strategies to improve tumor penetration of nanomedicines through nanoparticle design
- (2018) Ya-Ru Zhang et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
- (2018) Fred C. Lam et al. Nature Communications
- Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy
- (2018) Lili Chen et al. RSC Advances
- Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends
- (2018) Hira Choudhury et al. Drug Delivery and Translational Research
- A stabilized retro-inverso peptide ligand of transferrin receptor for enhanced liposome-based hepatocellular carcinoma-targeted drug delivery
- (2018) Jiajing Tang et al. Acta Biomaterialia
- Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
- (2018) J. Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Intracameral Delivery of Layer‐by‐Layer Coated siRNA Nanoparticles for Glaucoma Therapy
- (2018) Andrea E. Dillinger et al. Small
- Effective Therapy Using a Liposomal siRNA that Targets the Tumor Vasculature in a Model Murine Breast Cancer with Lung Metastasis
- (2018) Yu Sakurai et al. Molecular Therapy-Oncolytics
- Minicircle Versus Plasmid DNA Delivery by Receptor-Targeted Polyplexes
- (2017) Ana Krhac Levacic et al. HUMAN GENE THERAPY
- Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer
- (2017) Xiangsheng Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Polymer therapeutics and the EPR effect
- (2017) Hiroshi Maeda JOURNAL OF DRUG TARGETING
- In vitro and in vivo gene delivery using chitosan/hyaluronic acid nanoparticles: Influences of molecular mass of hyaluronic acid and lyophilization on transfection efficiency
- (2017) Toshinori Sato et al. JOURNAL OF GENE MEDICINE
- EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent
- (2017) Stephan Morys et al. MACROMOLECULAR BIOSCIENCE
- Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma
- (2017) Shanshan Wang et al. MOLECULAR THERAPY
- Lipid Nanoparticle Systems for Enabling Gene Therapies
- (2017) Pieter R. Cullis et al. MOLECULAR THERAPY
- Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
- (2017) Y. Anraku et al. Nature Communications
- Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene
- (2017) Kathrin A. Schmohl et al. Oncotarget
- Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids
- (2017) Minjie Sun et al. Advanced Healthcare Materials
- Engineering the human blood-brain barrier in vitro
- (2017) John J. Jamieson et al. Journal of Biological Engineering
- Recent progress in development of siRNA delivery vehicles for cancer therapy
- (2016) Hyun Jin Kim et al. ADVANCED DRUG DELIVERY REVIEWS
- Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery
- (2016) Yilong Cheng et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization
- (2016) Melissa Santi et al. BIOCONJUGATE CHEMISTRY
- iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes
- (2016) Lorena Simón-Gracia et al. BIOMATERIALS
- Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety
- (2016) Satoshi Uchida et al. BIOMATERIALS
- Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery
- (2016) Benjamí Oller-Salvia et al. CHEMICAL SOCIETY REVIEWS
- Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo
- (2016) Linda Beckert et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes
- (2016) Dian-Jang Lee et al. JOURNAL OF CONTROLLED RELEASE
- The neuropilin-1 receptor mediates enhanced tumor delivery of H2K polyplexes
- (2016) Qixin Leng et al. JOURNAL OF GENE MEDICINE
- Sequence-defined cMET/HGFR-targeted Polymers as Gene Delivery Vehicles for the Theranostic Sodium Iodide Symporter (NIS) Gene
- (2016) Sarah Urnauer et al. MOLECULAR THERAPY
- Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy
- (2016) Dangge Wang et al. NANO LETTERS
- Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy
- (2016) Hua Gong et al. NANO LETTERS
- Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy
- (2016) Hao Zhou et al. NANO LETTERS
- Surface charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines
- (2016) Hong-Xia Wang et al. Nano Today
- Translating nanoparticulate-personalized cancer vaccines into clinical applications: case study with RNA-lipoplexes for the treatment of melanoma
- (2016) Stephan Grabbe et al. Nanomedicine
- EGF receptor targeted lipo-oligocation polyplexes for antitumoral siRNA and miRNA delivery
- (2016) Katharina Müller et al. NANOTECHNOLOGY
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery
- (2016) Yu Matsumoto et al. Nature Nanotechnology
- Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers
- (2016) Susanne Schöttler et al. Nature Nanotechnology
- From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
- (2016) William A. Banks NATURE REVIEWS DRUG DISCOVERY
- Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery
- (2016) Guoyong Zhou et al. Polymer Chemistry
- Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing
- (2016) Chao Chen et al. Small
- Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nanocore with an Influenza Peptide and Transferrin Shell
- (2016) Wei Zhang et al. Advanced Healthcare Materials
- Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes
- (2015) Anders E. Hansen et al. ACS Nano
- Delivery of oligonucleotides with lipid nanoparticles
- (2015) Yuhua Wang et al. ADVANCED DRUG DELIVERY REVIEWS
- Structure-Invertible Nanoparticles for Triggered Co-Delivery of Nucleic Acids and Hydrophobic Drugs for Combination Cancer Therapy
- (2015) Kai Wang et al. ADVANCED FUNCTIONAL MATERIALS
- Applying the Retro-Enantio Approach To Obtain a Peptide Capable of Overcoming the Blood-Brain Barrier
- (2015) Roger Prades et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Enhanced blood–brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system
- (2015) Hui Yao et al. BIOMATERIALS
- Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration
- (2015) Nianhang Chen et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer
- (2015) Jenny G. Parvani et al. CANCER RESEARCH
- Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)
- (2015) Ulrich Lächelt et al. CHEMICAL REVIEWS
- p-Aminophenyl-α-d-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain
- (2015) Indu Singh et al. CHEMISTRY AND PHYSICS OF LIPIDS
- Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier
- (2015) Jin-Ming Li et al. International Journal of Nanomedicine
- Polyion complex micelles composed of pegylated polyasparthydrazide derivatives for siRNA delivery to the brain
- (2015) Hong Huo et al. JOURNAL OF COLLOID AND INTERFACE SCIENCE
- Enhanced gene expression in the brain following intravenous administration of lactoferrin-bearing polypropylenimine dendriplex
- (2015) Sukrut Somani et al. JOURNAL OF CONTROLLED RELEASE
- Improving drug delivery to solid tumors: Priming the tumor microenvironment
- (2015) Iftikhar Ali Khawar et al. JOURNAL OF CONTROLLED RELEASE
- Combination of sequence-defined oligoaminoamides with transferrin-polycation conjugates for receptor-targeted gene delivery
- (2015) Wei Zhang et al. JOURNAL OF GENE MEDICINE
- Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI–PCL–PEG–Fol)
- (2015) Li Liu et al. MOLECULAR PHARMACEUTICS
- Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer
- (2015) Petra Kos et al. Nanoscale
- Principles of nanoparticle design for overcoming biological barriers to drug delivery
- (2015) Elvin Blanco et al. NATURE BIOTECHNOLOGY
- Clinical experiences with systemically administered siRNA-based therapeutics in cancer
- (2015) Jonathan E. Zuckerman et al. NATURE REVIEWS DRUG DISCOVERY
- Peptide-like Polymers Exerting Effective Glioma-Targeted siRNA Delivery and Release for Therapeutic Application
- (2015) Sai An et al. Small
- Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid
- (2015) Manuela Porru et al. Oncotarget
- Brain-Penetrating Nanoparticles Improve Paclitaxel Efficacy in Malignant Glioma Following Local Administration
- (2014) Elizabeth Nance et al. ACS Nano
- Bimodal Tumor-Targeting from Microenvironment Responsive Hyaluronan Layer-by-Layer (LbL) Nanoparticles
- (2014) Erik C. Dreaden et al. ACS Nano
- Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas
- (2014) Zhen-Zhen Yang et al. BIOMATERIALS
- Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors
- (2014) Zhishen Ge et al. BIOMATERIALS
- Current approaches to enhance CNS delivery of drugs across the brain barriers
- (2014) Cui-Tao Lu et al. International Journal of Nanomedicine
- Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
- (2014) Michel Demeule et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of glucose transporters in the distribution of p-aminophenyl-α-d-mannopyranoside modified liposomes within mice brain
- (2014) Dan Du et al. JOURNAL OF CONTROLLED RELEASE
- Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy
- (2014) Luís Novo et al. JOURNAL OF CONTROLLED RELEASE
- Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499
- (2014) Hidenori Ando et al. JOURNAL OF CONTROLLED RELEASE
- Transferrin Receptor-Mediated Endocytosis: A Useful Target for Cancer Therapy
- (2014) Stephanie Tortorella et al. JOURNAL OF MEMBRANE BIOLOGY
- A multilayered cell culture model for transport study in solid tumors: Evaluation of tissue penetration of polyethyleneimine based cationic micelles
- (2014) Seiji Miura et al. Nano Today
- In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors
- (2014) Phil Oh et al. NATURE MEDICINE
- Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma
- (2014) Olivier L. Chinot et al. NEW ENGLAND JOURNAL OF MEDICINE
- Choline transporter-targeting and co-delivery system for glioma therapy
- (2013) Jianfeng Li et al. BIOMATERIALS
- CGKRK-modified nanoparticles for dual-targeting drug delivery to tumor cells and angiogenic blood vessels
- (2013) Quanyin Hu et al. BIOMATERIALS
- The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect
- (2013) Hiroshi Maeda CANCER SCIENCE
- Phase I Study of GRN1005 in Recurrent Malignant Glioma
- (2013) J. Drappatz et al. CLINICAL CANCER RESEARCH
- T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting
- (2013) Yuyang Kuang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system
- (2013) Yu Sakurai et al. JOURNAL OF CONTROLLED RELEASE
- Systemic TNFα Gene Therapy Synergizes With Liposomal Doxorubicine in the Treatment of Metastatic Cancer
- (2013) Baowei Su et al. MOLECULAR THERAPY
- Multifunctional Hierarchically Assembled Nanostructures as Complex Stage-Wise Dual-Delivery Systems for Coincidental Yet Differential Trafficking of siRNA and Paclitaxel
- (2013) Mahmoud Elsabahy et al. NANO LETTERS
- Copolymer of poly(ethylene glycol) and poly(l-lysine) grafting polyethylenimine through a reducible disulfide linkage for siRNA delivery
- (2013) Jingguo Li et al. Nanoscale
- Nanosized Multifunctional Polyplexes for Receptor-Mediated SiRNA Delivery
- (2012) Christian Dohmen et al. ACS Nano
- Target delivery of a gene into the brain using the RVG29-oligoarginine peptide
- (2012) Cheng Gong et al. BIOMATERIALS
- Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles
- (2012) Hongliang Xin et al. BIOMATERIALS
- De Novo Design of a Tumor-Penetrating Peptide
- (2012) L. Alberici et al. CANCER RESEARCH
- Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting
- (2012) Fulan Xie et al. International Journal of Nanomedicine
- Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment
- (2012) Lígia C. Gomes-da-Silva et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors
- (2012) Galith Abourbeh et al. IUBMB LIFE
- Drug delivery research in Europe
- (2012) Twan Lammers JOURNAL OF CONTROLLED RELEASE
- Structure–activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides
- (2012) Thomas Fröhlich et al. JOURNAL OF CONTROLLED RELEASE
- Tuning Nanoparticle Uptake: Live-Cell Imaging Reveals Two Distinct Endocytosis Mechanisms Mediated by Natural and Artificial EGFR Targeting Ligand
- (2012) Frauke M. Mickler et al. NANO LETTERS
- TGF- blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma
- (2012) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4
- (2012) Y. Ren et al. Science Translational Medicine
- Modern methods for delivery of drugs across the blood–brain barrier
- (2011) Yan Chen et al. ADVANCED DRUG DELIVERY REVIEWS
- Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery
- (2011) David Schaffert et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers
- (2011) Olivia M. Merkel et al. BIOMATERIALS
- Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma
- (2011) Shixian Huang et al. BIOMATERIALS
- A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA
- (2011) Do Won Hwang et al. BIOMATERIALS
- The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles
- (2011) Kai Xiao et al. BIOMATERIALS
- Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides
- (2011) Jingwei Li et al. BIOMATERIALS
- MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma
- (2011) A. F. Ibrahim et al. CANCER RESEARCH
- EGFR-Homing dsRNA Activates Cancer-Targeted Immune Response and Eliminates Disseminated EGFR-Overexpressing Tumors in Mice
- (2011) A. Shir et al. CLINICAL CANCER RESEARCH
- Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation
- (2011) A. Schäfer et al. HUMAN GENE THERAPY
- Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy
- (2011) Yu Nie et al. JOURNAL OF CONTROLLED RELEASE
- Odd–Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles
- (2011) Hirokuni Uchida et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
- (2011) Michael S D Kormann et al. NATURE BIOTECHNOLOGY
- Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
- (2011) H. Cabral et al. Nature Nanotechnology
- Transtumoral targeting enabled by a novel neuropilin-binding peptide
- (2011) L Roth et al. ONCOGENE
- Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines
- (2011) David Schaffert et al. ORGANIC LETTERS
- Transferrin Adsorption onto PLGA Nanoparticles Governs Their Interaction with Biological Systems from Blood Circulation to Brain Cancer Cells
- (2011) Jiang Chang et al. PHARMACEUTICAL RESEARCH
- More Effective Nanomedicines through Particle Design
- (2011) Jin Wang et al. Small
- A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma
- (2010) Hiroto Hatakeyama et al. ADVANCED DRUG DELIVERY REVIEWS
- Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier
- (2010) Sejin Son et al. BIOMATERIALS
- DNA/polyethyleneimine/hyaluronic acid small complex particles and tumor suppression in mice
- (2010) Tomoko Ito et al. BIOMATERIALS
- Chemical vectors for gene delivery: uptake and intracellular trafficking
- (2010) Chantal Pichon et al. CURRENT OPINION IN BIOTECHNOLOGY
- Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposome
- (2010) Ayele H. Negussie et al. JOURNAL OF CONTROLLED RELEASE
- New Angiopep-Modified Doxorubicin (ANG1007) and Etoposide (ANG1009) Chemotherapeutics With Increased Brain Penetration
- (2010) Christian Ché et al. JOURNAL OF MEDICINAL CHEMISTRY
- Folate-Targeted Therapies for Cancer
- (2010) Wei Xia et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy
- (2010) Yunching Chen et al. MOLECULAR THERAPY
- Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
- (2010) Mark E. Davis et al. NATURE
- Delivering nanomedicine to solid tumors
- (2010) Rakesh K. Jain et al. Nature Reviews Clinical Oncology
- Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier
- (2010) David Schaffert et al. PHARMACEUTICAL RESEARCH
- Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs
- (2010) K. N. Sugahara et al. SCIENCE
- Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery
- (2009) Koen Raemdonck et al. ADVANCED FUNCTIONAL MATERIALS
- Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles
- (2009) Yang Liu et al. BIOMATERIALS
- Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer
- (2009) Weilun Ke et al. BIOMATERIALS
- Selective Filtering of Particles by the Extracellular Matrix: An Electrostatic Bandpass
- (2009) Oliver Lieleg et al. BIOPHYSICAL JOURNAL
- Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors
- (2009) Kazuki N. Sugahara et al. CANCER CELL
- Delivery of small-interfering RNA (siRNA) to the brain
- (2009) Saroj P Mathupala EXPERT OPINION ON THERAPEUTIC PATENTS
- Tat-BMPs-PAMAM Conjugates Enhance Therapeutic Effect of Small Interference RNA on U251 Glioma Cells In Vitro and In Vivo
- (2009) Lei Han et al. HUMAN GENE THERAPY
- Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals
- (2009) Xue Ying et al. JOURNAL OF CONTROLLED RELEASE
- The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic
- (2009) Mark E. Davis MOLECULAR PHARMACEUTICS
- Inhibitor of Growth 4 Induces Growth Suppression and Apoptosis in Glioma U87MG
- (2009) XiaoMei Li et al. PATHOBIOLOGY
- C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
- (2009) T. Teesalu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives
- (2008) Kentaro Sasaki et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
- (2008) A Régina et al. BRITISH JOURNAL OF PHARMACOLOGY
- Gene therapy progress and prospects: synthetic polymer-based systems
- (2008) D Schaffert et al. GENE THERAPY
- Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2
- (2008) Michel Demeule et al. JOURNAL OF NEUROCHEMISTRY
- Polyplex Micelles with Cyclic RGD Peptide Ligands and Disulfide Cross-Links Directing to the Enhanced Transfection via Controlled Intracellular Trafficking
- (2008) Makoto Oba et al. MOLECULAR PHARMACEUTICS
- Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran
- (2008) Nicole Tietze et al. OLIGONUCLEOTIDES
- LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies
- (2008) Anna P. Lillis et al. PHYSIOLOGICAL REVIEWS
- Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
- (2008) E. A. Murphy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now