Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy

Adhesion Deregulation in Acute Myeloid Leukaemia

(2019) Alicja Gruszka et al.   Cells

Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing

(2019) Jiah Shin Chin et al.   Acta Biomaterialia

Cellular therapy for acute myeloid Leukemia – Current status and future prospects

(2019) Panupong Hansrivijit et al.   BLOOD REVIEWS

Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges

(2019) Rory M. Shallis et al.   BLOOD REVIEWS

Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations

(2019) Reza Shahbazi et al.   NATURE MATERIALS

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery

(2018) Dan Shao et al.   ADVANCED MATERIALS

Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins

(2018) Yamin Li et al.   BIOMATERIALS

IL1RAP potentiates multiple oncogenic signaling pathways in AML

(2018) Kelly Mitchell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Scaffold-mediated delivery for non-viral mRNA vaccines

(2018) Ruying Chen et al.   GENE THERAPY

Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles

(2018) Yamin Li et al.   Biomaterials Science

Scaffold Mediated Gene Knockdown for Neuronal Differentiation of Human Neural Progenitor Cells

(2018) Wai Hon Chooi et al.   Biomaterials Science

Coaxial Hydro-Nanofibrils for Self-Assembly of Cell Sheets Producing Skin Bilayers

(2018) Wei Mao et al.   ACS Applied Materials & Interfaces

CML hematopoietic stem cells expressing IL-1RAP can be targeted by chimeric antigen receptor (CAR)-engineered T cells

(2018) Walid Warda et al.   CANCER RESEARCH

Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets

(2018) Haibao Zhu et al.   Nature Biomedical Engineering

Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

(2017) Chang Liu et al.   JOURNAL OF CONTROLLED RELEASE

Tracing the origins of relapse in acute myeloid leukaemia to stem cells

(2017) Liran I. Shlush et al.   NATURE

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

(2017) Brett T Staahl et al.   NATURE BIOTECHNOLOGY

Precision oncology for acute myeloid leukemia using a knowledge bank approach

(2017) Moritz Gerstung et al.   NATURE GENETICS

Class 2 CRISPR–Cas RNA-guided endonucleases: Swiss Army knives of genome editing

(2017) Stefano Stella et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Class 2 CRISPR–Cas RNA-guided endonucleases: Swiss Army knives of genome editing

(2017) Stefano Stella et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Electrospun nanofibrils embedded hydrogel composites for cell cultivation in a biomimetic environment

(2017) Sol Lee et al.   RSC Advances

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

(2016) H. Agerstam et al.   BLOOD

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

(2016) Addison V. Wright et al.   CELL

Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function

(2016) Wansong Chen et al.   Nanoscale

A 17-gene stemness score for rapid determination of risk in acute leukaemia

(2016) Stanley W. K. Ng et al.   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

(2016) Ming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mussel Adhesion-Inspired Reverse Transfection Platform Enhances Osteogenic Differentiation and Bone Formation of Human Adipose-Derived Stem Cells

(2016) Jisoo Shin et al.   Small

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surface-polymerized biomimetic nanofibrils for the cell-directed association of 3-D scaffolds

(2015) Hye Sung Kim et al.   CHEMICAL COMMUNICATIONS

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Inducible in vivo genome editing with CRISPR-Cas9

(2015) Lukas E Dow et al.   NATURE BIOTECHNOLOGY

Photoactivatable CRISPR-Cas9 for optogenetic genome editing

(2015) Yuta Nihongaki et al.   NATURE BIOTECHNOLOGY

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia

(2015) Helena Ågerstam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

(2014) Hao Yin et al.   NATURE BIOTECHNOLOGY

Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells

(2013) Wei Ching Low et al.   BIOMATERIALS

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

(2013) M. Askmyr et al.   BLOOD

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

(2012) L. Barreyro et al.   BLOOD

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

(2012) Alessandro Parodi et al.   Nature Nanotechnology

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein

(2010) M. Jaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY