More Effective Nanomedicines through Particle Design

Nanoparticle-Cell Interactions: Drug Delivery Implications

(2012) Oshrat Harush-Frenkel et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings

(2011) Elizabeth M. Enlow et al.   NANO LETTERS

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

(2011) T. J. Merkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the Genomes of Cancer Cells: Progress and Promise

(2011) M. R. Stratton   SCIENCE

Cancer Research and the $90 Billion Metaphor

(2011) E. Marshall   SCIENCE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil-Mediated Cross-Linking of Antigens on the Cell Surface

(2010) Kuangshi Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles

(2010) Chunbai He et al.   BIOMATERIALS

Strategies for the intracellular delivery of nanoparticles

(2010) Leo Y. T. Chou et al.   CHEMICAL SOCIETY REVIEWS

Nanoscale interfaces to biology

(2010) Sunho Park et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Factors that Control the Circulation Time of Nanoparticles in Blood: Challenges, Solutions and Future Prospects

(2010) Jin-Wook Yoo et al.   CURRENT PHARMACEUTICAL DESIGN

Polymer particle shape independently influences binding and internalization by macrophages

(2010) Gaurav Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting

(2010) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Nanoparticles Deliver siRNA to Melanoma

(2010) Yunching Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tunable Bifunctional Silyl Ether Cross-Linkers for the Design of Acid-Sensitive Biomaterials

(2010) Matthew C. Parrott et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Intracellular Delivery of Antisense Oligonucleotides via Conjugation with Small-Molecule Ligands

(2010) Osamu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Complex Role of Multivalency in Nanoparticles Targeting the Transferrin Receptor for Cancer Therapies

(2010) Jin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptides for In Vivo Target-Specific Cancer Imaging

(2010) G. Ferro-Flores et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Challenging nature’s monopoly on the creation of well-defined nanoparticles

(2010) Wonhee Jeong et al.   Nanomedicine

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Macrophages Recognize Size and Shape of Their Targets

(2010) Nishit Doshi et al.   PLoS One

Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy

(2010) N. Kolishetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis

(2010) S. Bhattacharyya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer particles that switch shape in response to a stimulus

(2010) J.-W. Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanotechnology for synthetic high-density lipoproteins

(2010) Andrea J. Luthi et al.   TRENDS IN MOLECULAR MEDICINE

Designer Biomaterials for Nanomedicine

(2009) Nishit Doshi et al.   ADVANCED FUNCTIONAL MATERIALS

Nanomedicine-Challenge and Perspectives

(2009) Kristina Riehemann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

(2009) Alexander V. Kabanov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The association of silicon microparticles with endothelial cells in drug delivery to the vasculature

(2009) Rita E. Serda et al.   BIOMATERIALS

The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents

(2009) Gaurav Sahay et al.   BIOMATERIALS

Nanocarriers’ entry into the cell: relevance to drug delivery

(2009) Hervé Hillaireau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nanoparticle-based targeted drug delivery

(2009) Rajesh Singh et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Designed Auto-assembly of Nanostreptabodies for Rapid Tissue-specific Targetingin Vivo

(2009) Philippe Valadon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of bio-mimetic particles with enhanced vascular interaction

(2009) Sei-Young Lee et al.   JOURNAL OF BIOMECHANICS

Size and shape effects in the biodistribution of intravascularly injected particles

(2009) P. Decuzzi et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-Mediated IgE−Receptor Aggregation and Signaling in RBL Mast Cells

(2009) Yu-Fen Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Templated Spherical High Density Lipoprotein Nanoparticles

(2009) C. Shad Thaxton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates

(2009) David A. Giljohann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable, Shape-Specific, Top-Down Fabrication Methods for the Synthesis of Engineered Colloidal Particles

(2009) Timothy J. Merkel et al.   LANGMUIR

Novel Cationic Lipid That Delivers siRNA and Enhances Therapeutic Effect in Lung Cancer Cells

(2009) Yunching Chen et al.   MOLECULAR PHARMACEUTICS

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Aptamer Nano-flares for Molecular Detection in Living Cells

(2009) Dan Zheng et al.   NANO LETTERS

Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows

(2009) Sei-Young Lee et al.   NANOTECHNOLOGY

Fabrication of multiphasic and regio-specifically functionalized PRINT®particles of controlled size and shape

(2009) H Zhang et al.   NEW JOURNAL OF PHYSICS

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

(2009) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Surface Properties on Nanoparticle–Cell Interactions

(2009) Ayush Verma et al.   Small

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Surface Charge of Nanoparticles Determines Their Endocytic and Transcytotic Pathway in Polarized MDCK Cells

(2008) Oshrat Harush-Frenkel et al.   BIOMACROMOLECULES

The Receptor-Mediated Endocytosis of Nonspherical Particles

(2008) P. Decuzzi et al.   BIOPHYSICAL JOURNAL

Targeted Drugs and Nanomedicine: Present and Future

(2008) Paul Debbage   CURRENT PHARMACEUTICAL DESIGN

An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor

(2008) Sumio Chono et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

(2008) Mary-Catherine Bowman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Shape-Specific, Monodisperse Nano-Molding of Protein Particles

(2008) Jennifer Y. Kelly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA

(2008) Shyh-Dar Li et al.   MOLECULAR THERAPY

Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers

(2008) Silvia Muro et al.   MOLECULAR THERAPY

Cellular Trafficking of Quantum Dot-Ligand Bioconjugates and Their Induction of Changes in Normal Routing of Unconjugated Ligands

(2008) Christina Tekle et al.   NANO LETTERS

Targeted nanomedicines: effective treatment modalities for cancer, AIDS and brain disorders

(2008) Madaswamy S Muthu et al.   Nanomedicine

Seven challenges for nanomedicine

(2008) Wendy R. Sanhai et al.   Nature Nanotechnology

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Microfabricated Particles for Engineered Drug Therapies: Elucidation into the Mechanisms of Cellular Internalization of PRINT Particles

(2008) Stephanie E. A. Gratton et al.   PHARMACEUTICAL RESEARCH

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

(2008) F. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanotechnology and Cancer

(2007) James R. Heath et al.   Annual Review of Medicine

Design maps for nanoparticles targeting the diseased microvasculature

(2007) Paolo Decuzzi et al.   BIOMATERIALS

Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles

(2007) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-targeted Delivery of siRNA by Self-assembled Nanoparticles

(2007) Shyh-Dar Li et al.   MOLECULAR THERAPY