Engineering the human blood-brain barrier in vitro

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

Tissue-engineered 3D microvessel and capillary network models for the study of vascular phenomena

(2017) Max I. Bogorad et al.   MICROCIRCULATION

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

RETRACTED: In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

(2017) Kohei Yamamizu et al.   Stem Cell Reports

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels

(2016) Raleigh M. Linville et al.   Cellular and Molecular Bioengineering

Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform

(2016) Max I. Bogorad et al.   Integrative Biology

Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells

(2016) Matthew J. Stebbins et al.   METHODS

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

(2016) S. Aday et al.   TRENDS IN BIOTECHNOLOGY

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research

(2016) Abinaya Chandrasekaran et al.   Frontiers in Cellular Neuroscience

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Three-Dimensional Vascular Network Assembly From Diabetic Patient-Derived Induced Pluripotent Stem CellsSignificance

(2015) Xin Yi Chan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human astrocytes develop physiological morphology and remain quiescent in a novel 3D matrix

(2015) Amanda L. Placone et al.   BIOMATERIALS

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Human brain microvascular endothelial cells resist elongation due to shear stress

(2015) Adam Reinitz et al.   MICROVASCULAR RESEARCH

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

(2014) Joana Bicker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord

(2014) Dhruv Sareen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Extracellular Matrix Protein Laminin  2 Regulates the Maturation and Function of the Blood-Brain Barrier

(2014) M. J. Menezes et al.   JOURNAL OF NEUROSCIENCE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

Brain microvascular endothelial cells resist elongation due to curvature and shear stress

(2014) Mao Ye et al.   Scientific Reports

Defining Differences among Perivascular Cells Derived from Human Pluripotent Stem Cells

(2014) Maureen Wanjare et al.   Stem Cell Reports

Functionality of Endothelial Cells and Pericytes From Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts

(2013) Valeria V. Orlova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

(2013) Yutaro Hoshi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In vitro, in vivo and in silico models of drug distribution into the brain

(2013) Scott G. Summerfield et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix

(2013) S. Kusuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZ spheres: A stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs

(2013) Allison D. Ebert et al.   Stem Cell Research

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity

(2012) Omolara O. Ogunshola   CURRENT PHARMACEUTICAL DESIGN

Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals

(2012) Seong-Gi Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurovascular Unit: a Focus on Pericytes

(2012) Inês Sá-Pereira et al.   MOLECULAR NEUROBIOLOGY

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells

(2012) Gesine Paul et al.   PLoS One

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Multipotent Vasculogenic Pericytes From Human Pluripotent Stem Cells Promote Recovery of Murine Ischemic Limb

(2011) Ayelet Dar et al.   CIRCULATION

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage

(2011) Gokulan Thanabalasundaram et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative Membrane Protein Expression at the Blood–Brain Barrier of Adult and Younger Cynomolgus Monkeys

(2011) Katsuaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology

(2011) Arnold B. Etame et al.   Neurosurgical Focus

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions

(2010) Mira Lischper et al.   BRAIN RESEARCH

Regulation of the blood–brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro

(2010) Gokulan Thanabalasundaram et al.   BRAIN RESEARCH

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Biopharmaceutical drug targeting to the brain

(2010) William M. Pardridge   JOURNAL OF DRUG TARGETING

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

(2010) Michael J Bernas et al.   Nature Protocols

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Cell lineages and early patterns of embryonic CNS vascularization

(2010) Haymo Kurz   Cell Adhesion & Migration

Control of the Blood-Brain Barrier by Glucocorticoids and the Cells of the Neurovascular Unit

(2009) Susanne Kröll et al.   Annals of the New York Academy of Sciences

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Agrin, Aquaporin-4, and Astrocyte Polarity as an Important Feature of the Blood-Brain Barrier

(2009) Hartwig Wolburg et al.   NEUROSCIENTIST

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain endothelial cells and the glio-vascular complex

(2008) Hartwig Wolburg et al.   CELL AND TISSUE RESEARCH

Pericytes: Pluripotent Cells of the Blood Brain Barrier

(2008) Paula Dore-Duffy   CURRENT PHARMACEUTICAL DESIGN

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE

Pericyte–endothelial cell interaction increases MMP-9 secretion at the blood–brain barrier in vitro

(2007) Alla Zozulya et al.   BRAIN RESEARCH