Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery

Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method

(2016) Cyril Corbet et al.   JOURNAL OF CONTROLLED RELEASE

Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer

(2016) Haijun Yu et al.   Theranostics

Cationic Mucic Acid Polymer-Based siRNA Delivery Systems

(2015) Dorothy W. Pan et al.   BIOCONJUGATE CHEMISTRY

Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel

(2015) Shan Tang et al.   BIOMATERIALS

Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment strategy for head-and-neck cancer

(2015) Wei-Hua Chen et al.   CANCER LETTERS

Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma

(2015) C. Schmithals et al.   CANCER RESEARCH

Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy

(2015) Huizi Sha et al.   JOURNAL OF CONTROLLED RELEASE

Cellular uptake and in vivo distribution of polyhistidine peptides

(2015) Takashi Iwasaki et al.   JOURNAL OF CONTROLLED RELEASE

Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

(2015) Chun-Yang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancing Accumulation and Penetration of HPMA Copolymer–Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer

(2015) Zheng-Hong Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

(2015) Omar F. Khan et al.   NANO LETTERS

Cell uptake, intracellular distribution, fate and reactive oxygen species generation of polymer brush engineered CeO2−x NPs

(2015) Yuan Qiu et al.   Nanoscale

A reduction-dissociable PEG-b-PGAH-b-PEI triblock copolymer as a vehicle for targeted co-delivery of doxorubicin and P-gp siRNA

(2015) Minghui Xu et al.   Polymer Chemistry

Multifunctional ATRP based pH responsive polymeric nanoparticles for improved doxorubicin chemotherapy in breast cancer by proton sponge effect/endo-lysosomal escape

(2015) Shantanu V. Lale et al.   Polymer Chemistry

Tailoring the surface charge of dextran-based polymer coated SPIONs for modulated stem cell uptake and MRI contrast

(2015) Michael Barrow et al.   Biomaterials Science

A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted siRNA Delivery

(2014) Jingguo Li et al.   ADVANCED MATERIALS

iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy

(2014) C Puig-Saus et al.   GENE THERAPY

Co-Delivery of Doxorubicin and siRNA with Reduction and pH Dually Sensitive Nanocarrier for Synergistic Cancer Therapy

(2014) Weicai Chen et al.   Small

Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

(2013) Christopher E. Nelson et al.   ACS Nano

A novel class of polymeric pH-responsive MRI CEST agents

(2013) Shanrong Zhang et al.   CHEMICAL COMMUNICATIONS

Copolymer of poly(ethylene glycol) and poly(l-lysine) grafting polyethylenimine through a reducible disulfide linkage for siRNA delivery

(2013) Jingguo Li et al.   Nanoscale

Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

(2013) Haijun Yu et al.   Polymer Chemistry

Stimuli-responsive tertiary amine methacrylate-based block copolymers: Synthesis, supramolecular self-assembly and functional applications

(2013) Jinming Hu et al.   PROGRESS IN POLYMER SCIENCE

Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of siRNA delivery

(2012) Min Chen et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery

(2011) Haijun Yu et al.   ACS Nano

Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat

(2011) Du Cheng et al.   BIOMATERIALS

Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors

(2011) Jiangbing Zhou et al.   BIOMATERIALS

Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte

(2010) Shutao Guo et al.   ACS Nano

Proton Sponge Trick for pH-Sensitive Disassembly of Polyethylenimine-Based siRNA Delivery Systems

(2010) Gaelle Creusat et al.   BIOCONJUGATE CHEMISTRY

Polyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery

(2010) Jian Dai et al.   BIOMATERIALS

End-functional polymers, thiocarbonylthio group removal/transformation and reversible addition-fragmentation-chain transfer (RAFT) polymerization

(2010) Graeme Moad et al.   POLYMER INTERNATIONAL

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Tailoring Macromolecular Expression at Polymersome Surfaces

(2009) Adam Blanazs et al.   ADVANCED FUNCTIONAL MATERIALS

Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing

(2009) Seung-Young Lee et al.   JOURNAL OF CONTROLLED RELEASE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Surface Properties on Nanoparticle–Cell Interactions

(2009) Ayush Verma et al.   Small

Synthesis, characterization, and stimuli-sensitive properties of triblock copolymer poly(ethylene oxide)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(N-isopropylacrylamide)

(2008) Xuewei Xu et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA

(2008) Shyh-Dar Li et al.   MOLECULAR THERAPY