A Novel Therapeutic siRNA Nanoparticle Designed for Dual-Targeting CD44 and Gli1 of Gastric Cancer Stem Cells
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Novel Therapeutic siRNA Nanoparticle Designed for Dual-Targeting CD44 and Gli1 of Gastric Cancer Stem Cells
Authors
Keywords
-
Journal
International Journal of Nanomedicine
Volume Volume 15, Issue -, Pages 7013-7034
Publisher
Informa UK Limited
Online
2020-09-23
DOI
10.2147/ijn.s260163
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- KSP siRNA/paclitaxel-loaded PEGylated cationic liposomes for overcoming resistance to KSP inhibitors: Synergistic antitumor effects in drug-resistant ovarian cancer
- (2020) Jinju Lee et al. JOURNAL OF CONTROLLED RELEASE
- Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles
- (2019) Aqeel Ahmad et al. BIOCHIMIE
- Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma
- (2019) Ralf Gutzmer et al. Targeted Oncology
- Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery
- (2019) Byungji Kim et al. ADVANCED MATERIALS
- Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion
- (2019) Wai Hoong Chang et al. BRITISH JOURNAL OF CANCER
- The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective
- (2019) Yan Xu et al. Cell Communication and Signaling
- Hypoxia induced Sonic Hedgehog signaling regulates cancer stemness, epithelial-to-mesenchymal transition and invasion in cholangiocarcinoma
- (2019) Vikas Bhuria et al. EXPERIMENTAL CELL RESEARCH
- Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride
- (2018) Dan Liu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Hyaluronic acid-capped compact silica-supported mesoporous titania nanoparticles for ligand-directed delivery of doxorubicin
- (2018) Biki Gupta et al. Acta Biomaterialia
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Optimization of siRNA delivery to target sites: issues and future directions
- (2018) Ikramy A. Khalil et al. Expert Opinion on Drug Delivery
- Polyethylenimine-Spherical Nucleic Acid Nanoparticles Against Gli1 Reduce the Chemoresistance and Stemness of Glioblastoma Cells
- (2018) Jilian R. Melamed et al. MOLECULAR PHARMACEUTICS
- Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells
- (2018) Ita Novita Sari et al. Cells
- Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+Gastric Cancer Stem Cells
- (2017) Samarpita Barat et al. Stem Cells Translational Medicine
- Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis
- (2016) Zheng-qiang Liao et al. BMB Reports
- Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells
- (2016) Bing Long et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The Prognostic Significance of the Hedgehog Signaling Pathway in Colorectal Cancer
- (2016) Vassilis Papadopoulos et al. Clinical Colorectal Cancer
- Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells
- (2016) F Faião-Flores et al. ONCOGENE
- Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44+/Musashi-1+ gastric cancer stem cells
- (2015) Min Xu et al. CANCER LETTERS
- Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells
- (2015) Verline Justilien et al. CLINICAL CANCER RESEARCH
- Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update
- (2015) Naoko Takebe et al. Nature Reviews Clinical Oncology
- Hedgehog Signaling in the Maintenance of Cancer Stem Cells
- (2015) Catherine Cochrane et al. Cancers
- Chemoenzymatic Synthesis of Oligohyaluronan–Lipid Conjugates
- (2014) Dipali Ruhela et al. BIOCONJUGATE CHEMISTRY
- The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells
- (2014) Hong-juan Yao et al. BIOMATERIALS
- The prognostic value of CD44 expression in gastric cancer: A meta-Analysis
- (2014) Yansu Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- CD44 Expression Denotes a Subpopulation of Gastric Cancer Cells in Which Hedgehog Signaling Promotes Chemotherapy Resistance
- (2014) C. Yoon et al. CLINICAL CANCER RESEARCH
- Synthesis and optimization of a novel polymeric micelle based on hyaluronic acid and phospholipids for delivery of paclitaxel, in vitro and in-vivo evaluation
- (2014) Ebrahim Saadat et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Polymeric micelles based on hyaluronic acid and phospholipids: Design, characterization, and cytotoxicity
- (2014) Ebrahim Saadat et al. JOURNAL OF APPLIED POLYMER SCIENCE
- The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation
- (2014) Hiba Ahmad Zahreddine et al. NATURE
- Gli1 contributes to cellular resistance to cisplatin through altered cellular accumulation of the drug
- (2014) LAUREN AMABLE et al. ONCOLOGY REPORTS
- Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo
- (2013) Christopher E. Nelson et al. ACS Nano
- Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition
- (2013) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CD44+ gastric cancer cells with stemness properties are chemoradioresistant and highly invasive
- (2013) MAO SUN et al. Oncology Letters
- HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells
- (2012) Roberta Santini et al. STEM CELLS
- Cancer stem cell hypothesis and gastric carcinogenesis: Experimental evidence and unsolved questions
- (2012) Alba Rocco World Journal of Gastrointestinal Oncology
- Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients
- (2011) Tie Chen et al. CELL RESEARCH
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Identification of CD44+CD24+ gastric cancer stem cells
- (2011) Chaojun Zhang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Hyaluronan-coated nanoparticles: The influence of the molecular weight on CD44-hyaluronan interactions and on the immune response
- (2011) Shoshy Mizrahy et al. JOURNAL OF CONTROLLED RELEASE
- Mechanisms and functions of Hedgehog signalling across the metazoa
- (2011) Philip W. Ingham et al. NATURE REVIEWS GENETICS
- Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways
- (2010) Naoko Takebe et al. Nature Reviews Clinical Oncology
- Predictive Value of Cancer Stem-Like Cells and Cancer-Associated Genetic Markers for Peritoneal Recurrence of Colorectal Cancer in Patients after Curative Surgery
- (2010) Keisuke Nakamura et al. ONCOLOGY
- Lentivirus-mediated SMO RNA interference inhibits SMO expression and cell proliferation, and affects the cell cycle in LNCaP and PC3 cancer cell lines
- (2009) Bo Yang et al. ASIAN JOURNAL OF ANDROLOGY
- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
- (2009) Chen Zhao et al. NATURE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44
- (2009) Shigeo Takaishi et al. STEM CELLS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started