Nanomedicines functionalized with anti-EGFR ligands for active targeting in cancer therapy: Biological strategy, design and quality control

Engineered Protein Scaffolds as Next-Generation Therapeutics

(2020) Michaela Gebauer et al.   Annual Review of Pharmacology and Toxicology

Dual-Targeted Delivery of Nanoparticles Encapsulating Paclitaxel and Everolimus: a Novel Strategy to Overcome Breast Cancer Receptor Heterogeneity

(2020) Loujin Houdaihed et al.   PHARMACEUTICAL RESEARCH

An Overview of Antibody Conjugated Polymeric Nanoparticles for Breast Cancer Therapy

(2020) Alberto Juan et al.   Pharmaceutics

Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies

(2019) Jiwei Cui et al.   Advanced Healthcare Materials

Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts

(2019) Shota Yamamoto et al.   Acta Biomaterialia

Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

(2019) Jihye Yoo et al.   Cancers

Multifunctional nanomedicines for targeting epidermal growth factor receptor in colorectal cancer

(2019) Mostafa Akbarzadeh Khiavi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lung carcinoma therapy using epidermal growth factor receptor‑targeted lipid polymeric nanoparticles co‑loaded with cisplatin and doxorubicin

(2019) Yan Nan   ONCOLOGY REPORTS

Epidermal Growth Factor Receptor Family and its Role in Gastric Cancer

(2019) Chiara Arienti et al.   Frontiers in Oncology

Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles

(2019) Cristiana Marian Grapa et al.   International Journal of Nanomedicine

Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

(2019) Xiaodong Xie et al.   Nature Communications

Panitumumab-Conjugated and Platinum-Cored pH-Sensitive Apoferritin Nanocages for Colorectal Cancer-Targeted Therapy

(2018) Chun-Yen Lin et al.   ACS Applied Materials & Interfaces

Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer

(2018) Tingting Lv et al.   Acta Biomaterialia

Fe3O4@Au composite magnetic nanoparticles modified with cetuximab for targeted magneto-photothermal therapy of glioma cells

(2018) Qianling Lu et al.   International Journal of Nanomedicine

EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles

(2018) Wen-Hsuan Tsai et al.   International Journal of Nanomedicine

Electrostatically assembled dendrimer complex with a high-affinity protein binder for targeted gene delivery

(2018) Jong-won Kim et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona

(2018) Manuel Tonigold et al.   Nature Nanotechnology

Bispecific antibodies for cancer therapy: A review

(2018) Anuradha Krishnamurthy et al.   PHARMACOLOGY & THERAPEUTICS

Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment

(2018) Zhen Zhang et al.   International Journal of Nanomedicine

Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors

(2018) Ying Zhang et al.   Nanoscale

111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells

(2018) Martin R. Gill et al.   Nanoscale

Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 (BRCA2) Mutation

(2018) Chong Du et al.   ACS Nano

Development of a novel thermal-sensitive multifunctional liposome with antibody conjugation to target EGFR-expressing tumors

(2018) Kuan-Chieh Liu et al.   Nanomedicine-Nanotechnology Biology and Medicine

A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer

(2018) Jeffrey R. Ashton et al.   PLoS One

Anti-EGFR anchored paclitaxel loaded PLGA nanoparticles for the treatment of triple negative breast cancer. In-vitro and in-vivo anticancer activities

(2018) Vijayan Venugopal et al.   PLoS One

Overexpression of Epidermal Growth Factor Receptor (EGFR) and HER-2 in Bladder Carcinoma and Its Association with Patients’ Clinical Features

(2018) Wei Li et al.   MEDICAL SCIENCE MONITOR

Targeted cancer therapy through antibody fragments-decorated nanomedicines

(2017) Abbas Alibakhshi et al.   JOURNAL OF CONTROLLED RELEASE

64Cu-Labeled Repebody Molecules for Imaging of Epidermal Growth Factor Receptor–Expressing Tumors

(2017) Ayoung Pyo et al.   JOURNAL OF NUCLEAR MEDICINE

Bioconjugated fluorescent organic nanoparticles targeting EGFR-overexpressing cancer cells

(2017) Adrien Faucon et al.   Nanoscale

EGFR-targeting PLGA-PEG nanoparticles as a curcumin delivery system for breast cancer therapy

(2017) Hua Jin et al.   Nanoscale

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

(2017) Daniel A. Richards et al.   Chemical Science

Enhanced EGFR Targeting Activity of Plasmonic Nanostructures with Engineered GE11 Peptide

(2017) Francesca Biscaglia et al.   Advanced Healthcare Materials

Cancer-targeted Nucleic Acid Delivery and Quantum Dot Imaging Using EGF Receptor Aptamer-conjugated Lipid Nanoparticles

(2017) Min Woo Kim et al.   Scientific Reports

Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer

(2016) Ashley M. Brinkman et al.   BIOMATERIALS

Aptamer Functionalized Cisplatin-Albumin Nanoparticles for Targeted Delivery to Epidermal Growth Factor Receptor Positive Cervical Cancer

(2016) Yao Chen et al.   Journal of Biomedical Nanotechnology

Antitumor effect and safety profile of systemically delivered oncolytic adenovirus complexed with EGFR-targeted PAMAM-based dendrimer in orthotopic lung tumor model

(2016) A-Rum Yoon et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Combination wt-p53 and MicroRNA-125b Transfection in a Genetically Engineered Lung Cancer Model Using Dual CD44/EGFR-targeting Nanoparticles

(2016) Meghna Talekar et al.   MOLECULAR THERAPY

Fast Targeting and Cancer Cell Uptake of Luminescent Antibody-Nanozeolite Bioconjugates

(2016) Riccardo Marega et al.   Small

Dendrimer-assisted hydrophilic magnetic nanoparticles as sensitive substrates for rapid recognition and enhanced isolation of target tumor cells

(2016) Peiming Zhang et al.   TALANTA

Bispecific Antibody Conjugated Manganese-Based Magnetic Engineered Iron Oxide for Imaging of HER2/neu- and EGFR-Expressing Tumors

(2016) Shou-Cheng Wu et al.   Theranostics

In vivo Biocompatibility, Biodistribution and Therapeutic Efficiency of Titania Coated Upconversion Nanoparticles for Photodynamic Therapy of Solid Oral Cancers

(2016) Sasidharan Swarnalatha Lucky et al.   Theranostics

EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy

(2016) Catarina Oliveira Silva et al.   PLoS One

Detection and Imaging of Aggressive Cancer Cells Using an Epidermal Growth Factor Receptor (EGFR)-Targeted Filamentous Plant Virus-Based Nanoparticle

(2015) Paul L. Chariou et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Molecularly targeted gemcitabine-loaded nanoparticulate system towards the treatment of EGFR overexpressing lung cancer

(2015) Xian-Bao Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Electrochemical aptamer/antibody based sandwich immunosensor for the detection of EGFR, a cancer biomarker, using gold nanoparticles as a signaling probe

(2015) Hoda Ilkhani et al.   BIOSENSORS & BIOELECTRONICS

Challenges and opportunities for non-antibody scaffold drugs

(2015) Rodrigo Vazquez-Lombardi et al.   DRUG DISCOVERY TODAY

Radionuclide therapy using 131I-labeled anti-epidermal growth factor receptor-targeted nanoparticles suppresses cancer cell growth caused by EGFR overexpression

(2015) Wei Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Demethoxycurcumin-Carrying Chitosan–Antibody Core–Shell Nanoparticles with Multitherapeutic Efficacy toward Malignant A549 Lung Tumor: From in Vitro Characterization to in Vivo Evaluation

(2015) Wei-Ting Huang et al.   MOLECULAR PHARMACEUTICS

Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, 177Lu

(2015) Simmyung Yook et al.   MOLECULAR PHARMACEUTICS

Epidermal growth factor receptor-targeted lipid nanoparticles retain self-assembled nanostructures and provide high specificity

(2015) Jiali Zhai et al.   Nanoscale

Tumor-targeted and immune-targeted monoclonal antibodies: Going from passive to active immunotherapy

(2015) Aurélien Marabelle et al.   PEDIATRIC BLOOD & CANCER

Aptamers and Their Applications in Nanomedicine

(2015) Hongguang Sun et al.   Small

Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells

(2015) Jun Lia et al.   Oncotarget

Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

(2014) Koo Chul Kwon et al.   ADVANCED MATERIALS

Antibody Quantum Dot Conjugates Developed via Copper-Free Click Chemistry for Rapid Analysis of Biological Samples Using a Microfluidic Microsphere Array System

(2014) Nalinikanth Kotagiri et al.   BIOCONJUGATE CHEMISTRY

Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data

(2014) S.E.D.C. Jorge et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Enhanced cytotoxic activity of cetuximab in EGFR-positive lung cancer by conjugating with gold nanoparticles

(2014) Yichun Qian et al.   Scientific Reports

Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

(2014) Hongguang Sun et al.   Molecular Therapy-Nucleic Acids

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Evaluation of EGFR-targeted radioimmuno-gold-nanoparticles as a theranostic agent in a tumor animal model

(2013) Hao-Wen Kao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cetuximab conjugated O-carboxymethyl chitosan nanoparticles for targeting EGFR overexpressing cancer cells

(2013) S. Maya et al.   CARBOHYDRATE POLYMERS

Biodistribution and Pharmacokinetics of EGFR-Targeted Thiolated Gelatin Nanoparticles Following Systemic Administration in Pancreatic Tumor-Bearing Mice

(2013) Jing Xu et al.   MOLECULAR PHARMACEUTICS

The Role of Epidermal Growth Factor Receptor in Cancer Metastasis and Microenvironment

(2013) Takamitsu Sasaki et al.   Biomed Research International

scFv Antibody: Principles and Clinical Application

(2012) Zuhaida Asra Ahmad et al.   Clinical & Developmental Immunology

Antibody-Conjugated Nanoparticles for Therapeutic Applications

(2012) M. M. Cardoso et al.   CURRENT MEDICINAL CHEMISTRY

A novel EGFR-targeted gene delivery system based on complexes self-assembled by EGF, DNA, and activated PAMAM dendrimers

(2012) Xiaoning Zhang et al.   International Journal of Nanomedicine

Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells

(2012) Isil Altintas et al.   JOURNAL OF CONTROLLED RELEASE

EGF receptor-targeted nanocarriers for enhanced cancer treatment

(2012) Alyssa M Master et al.   Nanomedicine

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

(2012) Mi Kyung Yu et al.   Theranostics

A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth

(2011) Rob C. Roovers et al.   INTERNATIONAL JOURNAL OF CANCER

EGFR-targeted stearoyl gemcitabine nanoparticles show enhanced anti-tumor activity

(2011) Michael A. Sandoval et al.   JOURNAL OF CONTROLLED RELEASE

Affibody-Functionalized Gold-Silica Nanoparticles for Raman Molecular Imaging of the Epidermal Growth Factor Receptor

(2011) Jesse V. Jokerst et al.   Small

Characterization and Cancer Cell Specific Binding Properties of Anti-EGFR Antibody Conjugated Quantum Dots

(2010) Junghan Lee et al.   BIOCONJUGATE CHEMISTRY

Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin

(2010) Melarkode S. Ramakrishnan et al.   mAbs

Development of EGFR-Targeted Polymer Blend Nanocarriers for Combination Paclitaxel/Lonidamine Delivery To Treat Multi-Drug Resistance in Human Breast and Ovarian Tumor Cells

(2010) Lara Milane et al.   MOLECULAR PHARMACEUTICS

Inhibition of the EGFR with nanoparticles encapsulating antisense oligonucleotides of the EGFR enhances radiosensitivity in SCCVII cells

(2009) Yehui ping et al.   MEDICAL ONCOLOGY

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging

(2008) Lily Yang et al.   Small