Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids

Reaction-based small-molecule fluorescent probes for dynamic detection of ROS and transient redox changes in living cells and small animals

(2017) Rui Lü   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

(2017) Jicheng Yu et al.   NANO LETTERS

Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma

(2017) Bo Fan et al.   Theranostics

Arginine-Modified Nanostructured Lipid Carriers with Charge-Reversal and pH-Sensitive Membranolytic Properties for Anticancer Drug Delivery

(2017) Minjie Sun et al.   Advanced Healthcare Materials

Stimuli-Responsive Polymeric Nanocarriers for Efficient Gene Delivery

(2017) Yingqin Li et al.   Topics in Current Chemistry

Sialic Acid-Targeted Nanovectors with Phenylboronic Acid-Grafted Polyethylenimine Robustly Enhance siRNA-Based Cancer Therapy

(2016) Manyi Ji et al.   ACS Applied Materials & Interfaces

Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy

(2016) Liangzhu Feng et al.   ACS Nano

Near Infrared-Guided Smart Nanocarriers for MicroRNA-Controlled Release of Doxorubicin/siRNA with Intracellular ATP as Fuel

(2016) Penghui Zhang et al.   ACS Nano

Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer

(2016) Shan Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Reactive Oxygen Species: Physical, Chemical, and Biological Structures based on ROS-Sensitive Moieties that are Able to Respond to Oxidative Microenvironments (Adv. Mater. 27/2016)

(2016) Christos Tapeinos et al.   ADVANCED MATERIALS

Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy

(2016) Nasha Qiu et al.   ADVANCED MATERIALS

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

(2016) Chenggen Qian et al.   ADVANCED MATERIALS

Hypoxia-Sensitive Materials for Biomedical Applications

(2016) Jicheng Yu et al.   ANNALS OF BIOMEDICAL ENGINEERING

Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic

(2016) Kin Man Au et al.   BIOMATERIALS

A surface charge-switchable and folate modified system for co-delivery of proapoptosis peptide and p53 plasmid in cancer therapy

(2016) Si Chen et al.   BIOMATERIALS

Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery

(2016) Cong-Fei Xu et al.   BIOMATERIALS

Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery

(2016) Ching-Hsiang Fan et al.   BIOMATERIALS

Hypoxia-responsive nanocarriers for cancer imaging and therapy: recent approaches and future perspectives

(2016) Thavasyappan Thambi et al.   CHEMICAL COMMUNICATIONS

Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species

(2016) Xiaoqiang Chen et al.   CHEMICAL SOCIETY REVIEWS

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

(2016) Mahdi Karimi et al.   CHEMICAL SOCIETY REVIEWS

Intracellular redox-responsive nanocarrier for plasmid delivery: in vitro characterization and in vivo studies in mice

(2016) Lifen Zhang et al.   International Journal of Nanomedicine

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound

(2016) Brian P. Mead et al.   JOURNAL OF CONTROLLED RELEASE

The role of disulfide-bridge on the activities of H-shape gemini-like cationic lipid based siRNA delivery

(2016) Xiao-Fei Ma et al.   JOURNAL OF CONTROLLED RELEASE

Multiparameter evaluation of in vivo gene delivery using ultrasound-guided, microbubble-enhanced sonoporation

(2016) Galina Shapiro et al.   JOURNAL OF CONTROLLED RELEASE

Systemic delivery of siRNA by hyaluronan-functionalized calcium phosphate nanoparticles for tumor-targeted therapy

(2016) Chong Qiu et al.   Nanoscale

ATP/pH Dual Responsive Nanoparticle withd-[des-Arg10]Kallidin Mediated Efficient In Vivo Targeting Drug Delivery

(2016) Yu Zhang et al.   Small

Phenylboronic Acid-Mediated Tumor Targeting of Chitosan Nanoparticles

(2016) Xin Wang et al.   Theranostics

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Enhanced Therapeutic siRNA to Tumor Cells by a pH-Sensitive Agmatine–Chitosan Bioconjugate

(2015) Yongmao Li et al.   ACS Applied Materials & Interfaces

Nucleus-Targeting Gold Nanoclusters for Simultaneous In Vivo Fluorescence Imaging, Gene Delivery, and NIR-Light Activated Photodynamic Therapy

(2015) Raviraj Vankayala et al.   ADVANCED FUNCTIONAL MATERIALS

Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery

(2015) Xin Liu et al.   ADVANCED MATERIALS

Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

(2015) Cassandra E. Callmann et al.   ADVANCED MATERIALS

Combinatorial Approach to Nanoarchitectonics for Nonviral Delivery of Nucleic Acids

(2015) Mijanur Rahaman Molla et al.   ADVANCED MATERIALS

Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors

(2015) Yanyan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced antitumor efficacies of multifunctional nanocomplexes through knocking down the barriers for siRNA delivery

(2015) Lu Han et al.   BIOMATERIALS

Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery

(2015) Yulin Li et al.   CHEMICAL REVIEWS

Protease-triggered siRNA delivery vehicles

(2015) David B. Rozema et al.   JOURNAL OF CONTROLLED RELEASE

Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

(2015) Chun-Yang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene delivery by a cationic and thermosensitive nanogel promoted established tumor growth inhibition

(2015) Peng Cao et al.   Nanomedicine

Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics

(2015) Fatemeh Movahedi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

(2015) Jicheng Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Transfection and Detection of Gene Expression of Stem Cells Preloaded with DNA-carrying Microbubbles

(2015) Sidhartha Tavri et al.   RADIOLOGY

Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy

(2015) Hongmei Liu et al.   RSC Advances

Spatiotemporal Oxygen Sensing Using Dual Emissive Boron Dye–Polylactide Nanofibers

(2014) Daniel T. Bowers et al.   ACS Nano

Near-Infrared-Light-Based Nano-Platform Boosts Endosomal Escape and Controls Gene Knockdown in Vivo

(2014) Muthu Kumara Gnanasammandhan Jayakumar et al.   ACS Nano

Nucleic acid delivery with microbubbles and ultrasound

(2014) Joshua J. Rychak et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes

(2014) Tinghui Yin et al.   BIOMATERIALS

PEGylated carboxymethyl chitosan/calcium phosphate hybrid anionic nanoparticles mediated hTERT siRNA delivery for anticancer therapy

(2014) Ying Xie et al.   BIOMATERIALS

Effect of biodegradability on CXCR4 antagonism, transfection efficacy and antimetastatic activity of polymeric Plerixafor

(2014) Jing Li et al.   BIOMATERIALS

Matrix metalloproteinase 2-responsive micelle for siRNA delivery

(2014) Hong-Xia Wang et al.   BIOMATERIALS

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

(2014) Zhishen Ge et al.   BIOMATERIALS

Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer

(2014) Jing Xu et al.   BMC CANCER

Redox- and Hypoxia-Responsive MRI Contrast Agents

(2014) Quyen N. Do et al.   ChemMedChem

Fine-Tuning of Charge-Conversion Polymer Structure for Efficient Endosomal Escape of siRNA-Loaded Calcium Phosphate Hybrid Micelles

(2014) Yoshinori Maeda et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Enzyme-responsive nanomaterials for controlled drug delivery

(2014) Quanyin Hu et al.   Nanoscale

ATP-triggered anticancer drug delivery

(2014) Ran Mo et al.   Nature Communications

Ultrasound-Mediated Gene and Drug Delivery Using a Microbubble-Liposome Particle System

(2014) Young Il Yoon et al.   Theranostics

Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

(2013) Christopher E. Nelson et al.   ACS Nano

Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery

(2013) Daoshu Lin et al.   Acta Biomaterialia

Matrix Metalloproteinase Responsive, Proximity-Activated Polymeric Nanoparticles for siRNA Delivery

(2013) Hongmei Li et al.   ADVANCED FUNCTIONAL MATERIALS

Highly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan Nanoparticles

(2013) Qiuning Lin et al.   ADVANCED MATERIALS

Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo

(2013) Christopher E. Nelson et al.   ADVANCED MATERIALS

Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations

(2013) Chao Wu et al.   BIOMATERIALS

Imaging and therapy of liver fibrosis using bioreducible polyethylenimine/siRNA complexes conjugated with N-acetylglucosamine as a targeting moiety

(2013) Sun-Jung Kim et al.   BIOMATERIALS

Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery

(2013) Thavasyappan Thambi et al.   BIOMATERIALS

Core-Shell type lipid/rPAA-Chol polymer hybrid nanoparticles for in vivo siRNA delivery

(2013) Ling-Yan Gao et al.   BIOMATERIALS

New directions in thermoresponsive polymers

(2013) Debashish Roy et al.   CHEMICAL SOCIETY REVIEWS

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

(2013) Marina A. Dobrovolskaia et al.   JOURNAL OF CONTROLLED RELEASE

Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting

(2013) Hong Yeol Yoon et al.   JOURNAL OF CONTROLLED RELEASE

Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors

(2013) Stephanie Deshayes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP

(2013) Shuvendu Biswas et al.   Nature Chemistry

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

(2013) Christopher P. Guise et al.   Chinese Journal of Cancer

Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications

(2012) Min Suk Shim et al.   ADVANCED DRUG DELIVERY REVIEWS

A Phenylboronate-Functionalized Polyion Complex Micelle for ATP-Triggered Release of siRNA

(2012) Mitsuru Naito et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-Function CXCR4 Antagonist Polyplexes To Deliver Gene Therapy and Inhibit Cancer Cell Invasion

(2012) Jing Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium

(2012) Lu Sun et al.   BIOMATERIALS

Nanovector delivery of siRNA for cancer therapy

(2012) H Shen et al.   CANCER GENE THERAPY

Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease

(2012) José L. Tlaxca et al.   JOURNAL OF CONTROLLED RELEASE

Boronate-Mediated Biologic Delivery

(2012) Gregory A. Ellis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances in Nonviral Vectors for Gene Delivery

(2011) Xia Guo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics

(2011) Jessica L. Cohen et al.   BIOCONJUGATE CHEMISTRY

Odd–Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles

(2011) Hirokuni Uchida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity

(2010) Keiji Itaka et al.   BIOMATERIALS

Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics

(2010) Mahmoud Soliman et al.   CHEMICAL COMMUNICATIONS

Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown

(2010) Hyun Jin Kim et al.   JOURNAL OF CONTROLLED RELEASE

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

(2010) E. S. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioreducible polymers for gene delivery

(2010) Tae-il Kim et al.   REACTIVE & FUNCTIONAL POLYMERS

pH-dependent hemolysis of biocompatible imidazole-grafted polyaspartamide derivatives

(2009) Kwangwon Seo et al.   Acta Biomaterialia

Polyaspartamide-Based Oligo-ethylenimine Brushes with High Buffer Capacity and Low Cytotoxicity for Highly Efficient Gene Delivery

(2009) Min Zhang et al.   BIOCONJUGATE CHEMISTRY

The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection

(2009) Sebastian Neumann et al.   BIOMATERIALS

Fingerprint of Cell Metabolism in the Experimentally Observed Interstitial pH and pO2 in Solid Tumors

(2009) H. R. Molavian et al.   CANCER RESEARCH

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

Intelligent nucleic acid delivery systems based on stimuli-responsive polymers

(2009) Fu-Sheng Du et al.   Soft Matter

Enzyme-Responsive Nanoparticle Systems

(2008) James E. Ghadiali et al.   ADVANCED MATERIALS

Hyperthermia-Induced Targeting of Thermosensitive Gene Carriers to Tumors

(2008) Alenka Schwerdt et al.   HUMAN GENE THERAPY

Polyplexes from Poly(aspartamide) Bearing 1,2-Diaminoethane Side Chains Induce pH-Selective, Endosomal Membrane Destabilization with Amplified Transfection and Negligible Cytotoxicity

(2008) Kanjiro Miyata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

(2008) A. Okumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA