Nanoparticle-based delivery strategies of multifaceted immunomodulatory RNA for cancer immunotherapy

mRNA in cancer immunotherapy: beyond a source of antigen

(2021) Lien Van Hoecke et al.   Molecular Cancer

Multi-Immune Agonist Nanoparticle Therapy Stimulates Type I Interferons to Activate Antigen-Presenting Cells and Induce Antigen-Specific Antitumor Immunity

(2021) Elizabeth S. Levy et al.   MOLECULAR PHARMACEUTICS

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

(2021) Daniel E. Murphy et al.   NANO LETTERS

Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives

(2021) Zimei Wu et al.   PHARMACEUTICAL RESEARCH

Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines

(2021) Basmah N. Aldosari et al.   Pharmaceutics

Encapsulation state of messenger RNA inside lipid nanoparticles

(2021) Mark L. Brader et al.   BIOPHYSICAL JOURNAL

Novel therapies emerging in oncology to target the TGF-β pathway

(2021) Byung-Gyu Kim et al.   Journal of Hematology & Oncology

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

(2021) Christiana M. Neophytou et al.   Cancers

The Limitless Future of RNA Therapeutics

(2021) Tulsi Ram Damase et al.   Frontiers in Bioengineering and Biotechnology

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles

(2021) Christophe Delehedde et al.   Pharmaceutics

Clinical Advances of siRNA-Based Nanotherapeutics for Cancer Treatment

(2021) Dima Hattab et al.   Pharmaceutics

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis

(2020) Chao Zheng et al.   Frontiers in Molecular Neuroscience

Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives

(2020) Itziar Gómez-Aguado et al.   Nanomaterials

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

(2020) Kuan-Wei Huang et al.   Science Advances

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

(2020) Abishek Wadhwa et al.   Pharmaceutics

Immune checkpoint signaling and cancer immunotherapy

(2020) Xing He et al.   CELL RESEARCH

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence

(2020) Raju K. Vaddepally et al.   Cancers

Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

(2020) David C. Luther et al.   ADVANCED DRUG DELIVERY REVIEWS

Next-generation vaccine platforms for COVID-19

(2020) Debby van Riel et al.   NATURE MATERIALS

Barriers and strategies of cationic liposomes for cancer gene therapy

(2020) Chunyan Liu et al.   Molecular Therapy-Methods & Clinical Development

Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment

(2020) Susannah L Hewitt et al.   CLINICAL CANCER RESEARCH

mRNA Vaccine Era—Mechanisms, Drug Platform and Clinical Prospection

(2020) Shuqin Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Co-delivery of antigen and dual adjuvants by aluminum hydroxide nanoparticles for enhanced immune responses

(2020) Yingying Hou et al.   JOURNAL OF CONTROLLED RELEASE

Blockade of CTLA-4 increases anti-tumor response inducing potential of dendritic cell vaccine

(2020) Maryam Esmaily et al.   JOURNAL OF CONTROLLED RELEASE

Targeting EphA2 in cancer

(2020) Ta Xiao et al.   Journal of Hematology & Oncology

Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors

(2020) Iván Márquez-Rodas et al.   Science Translational Medicine

Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma

(2020) Anusha Kalbasi et al.   Science Translational Medicine

Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists

(2020) Max E. Jacobson et al.   ACS Central Science

Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside

(2020) Muhammad Imran Sajid et al.   Pharmaceuticals

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

(2020) Mohammad Ariful Islam et al.   BIOMATERIALS

Inhibiting RRM2 to enhance the anticancer activity of chemotherapy

(2020) Yaqiong Zhan et al.   BIOMEDICINE & PHARMACOTHERAPY

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

(2020) Carla B. Roces et al.   Pharmaceutics

Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle

(2020) Tongren Yang et al.   Bioactive Materials

Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives

(2020) Maochao Zheng et al.   Bioactive Materials

Unexpected role of hyaluronic acid in trafficking siRNA across cellular barrier: First biomimetic, anionic, non-viral transfection method

(2019) Maruthibabu Paidikondala et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

(2019) Yongshuai Jiang et al.   Human Vaccines & Immunotherapeutics

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

(2019) Susannah L. Hewitt et al.   Science Translational Medicine

Tryptophan Metabolism and Related Pathways in Psychoneuroimmunology: The Impact of Nutrition and Lifestyle

(2019) Johanna M. Gostner et al.   NEUROPSYCHOBIOLOGY

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Pathogen molecular pattern receptor agonists: treating cancer by mimicking infection

(2019) Mark Aleynick et al.   CLINICAL CANCER RESEARCH

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

(2019) Ghanbar Mahmoodi Chalbatani et al.   International Journal of Nanomedicine

Immunotherapeutic effects of intratumoral nanoplexed poly I:C

(2019) M. Angela Aznar et al.   Journal for ImmunoTherapy of Cancer

Current RNA-based Therapeutics in Clinical Trials

(2019) Ling-Yan Zhou et al.   CURRENT GENE THERAPY

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

(2019) Yuxin Lin et al.   Journal of Hematology & Oncology

Natural Polysaccharides for siRNA Delivery: Nanocarriers Based on Chitosan, Hyaluronic Acid, and Their Derivatives

(2019) Inés Serrano-Sevilla et al.   MOLECULES

Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications

(2019) Anna Angela Barba et al.   Pharmaceutics

Layered Double Hydroxide Nanoparticles for Efficient Gene Delivery for Cancer Treatment

(2019) Sudipta Senapati et al.   BIOCONJUGATE CHEMISTRY

Blockage of immune checkpoint molecules increases T‐cell priming potential of dendritic cell vaccine

(2019) Hadi Hassannia et al.   IMMUNOLOGY

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

(2019) Sergio Linares-Fernández et al.   TRENDS IN MOLECULAR MEDICINE

Development of Universal Influenza Vaccines Targeting Conserved Viral Proteins

(2019) Jazayeri et al.   Vaccines

Targeting innate sensing in the tumor microenvironment to improve immunotherapy

(2019) Zhida Liu et al.   Cellular & Molecular Immunology

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review

(2018) Muhammad Riaz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Glutamine-Rich Carrier Efficiently Delivers Anti-CD47 siRNA Driven by a “Glutamine Trap” To Inhibit Lung Cancer Cell Growth

(2018) Jiamin Wu et al.   MOLECULAR PHARMACEUTICS

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment

(2018) David L. Elion et al.   Oncotarget

Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?

(2018) Eros Marín et al.   Frontiers in Immunology

Mesoporous silica nanoparticles for drug and gene delivery

(2018) Yixian Zhou et al.   Acta Pharmaceutica Sinica B

Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers

(2018) David L Elion et al.   CANCER RESEARCH

Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer

(2018) Manisit Das et al.   MOLECULAR THERAPY

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

(2017) Sara Salatin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

(2017) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Nano-based delivery of RNAi in cancer therapy

(2017) Yong Xin et al.   Molecular Cancer

Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette–Guérin (BCG) via Synergistic Activation of Innate Immune Receptors

(2017) Martin T. Speth et al.   MOLECULAR PHARMACEUTICS

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Transforming growth factor-β: A therapeutic target for cancer

(2017) Sulsal Haque et al.   Human Vaccines & Immunotherapeutics

New Biotechnological Tools for the Genetic Improvement of Major Woody Fruit Species

(2017) Cecilia Limera et al.   Frontiers in Plant Science

MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice

(2017) Ling-xiao Zhang et al.   Journal of Materials Chemistry B

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

In vitro blood cell viability profiling of polymers used in molecular assembly

(2017) Hyejoong Jeong et al.   Scientific Reports

Progress and perspective of inorganic nanoparticle-based siRNA delivery systems

(2016) Ying Jiang et al.   Expert Opinion on Drug Delivery

Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation

(2016) Shi-Yong Li et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Cellular Delivery of RNA Nanoparticles

(2016) Lorena Parlea et al.   ACS Combinatorial Science

Production and clinical development of nanoparticles for gene delivery

(2016) Jie Chen et al.   Molecular Therapy-Methods & Clinical Development

In vivo stepwise immunomodulation using chitosan nanoparticles as a platform nanotechnology for cancer immunotherapy

(2016) Hee Dong Han et al.   Scientific Reports

JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter

(2015) Andreas H. Wagner et al.   BIOCHEMICAL PHARMACOLOGY

Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo

(2015) Zichao Luo et al.   BIOMATERIALS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines

(2015) Cleo Goyvaerts et al.   Journal of Immunology Research

Polymer nanoparticles for enhanced immune response: Combined delivery of tumor antigen and small interference RNA for immunosuppressive gene to dendritic cells

(2014) Min Beom Heo et al.   Acta Biomaterialia

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells

(2014) P Duewell et al.   CELL DEATH AND DIFFERENTIATION

IL-12 Produced by Dendritic Cells Augments CD8+ T Cell Activation through the Production of the Chemokines CCL1 and CCL17

(2014) C. J. Henry et al.   JOURNAL OF IMMUNOLOGY

Viral Phosphodiesterases That Antagonize Double-Stranded RNA Signaling to RNase L by Degrading 2-5A

(2014) Robert H. Silverman et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Gold Nanoparticles for Nucleic Acid Delivery

(2014) Ya Ding et al.   MOLECULAR THERAPY

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

(2014) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid Colony-Stimulating Factors as Regulators of Macrophage Polarization

(2014) Thomas A. Hamilton et al.   Frontiers in Immunology

pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

(2013) John T. Wilson et al.   ACS Nano

Programmed nanoparticles for combined immunomodulation, antigen presentation and tracking of immunotherapeutic cells

(2013) Min Beom Heo et al.   BIOMATERIALS

Therapeutic Efficacy of Bifunctional siRNA Combining TGF- 1 Silencing with RIG-I Activation in Pancreatic Cancer

(2013) J. Ellermeier et al.   CANCER RESEARCH

Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery

(2013) Christian Argyo et al.   CHEMISTRY OF MATERIALS

Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format

(2013) Kyle K.L. Phua et al.   JOURNAL OF CONTROLLED RELEASE

Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type

(2013) M. Firoz Mian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Preparation and Characterization of Liposome-Encapsulated Plasmid DNA for Gene Delivery

(2013) Rachel M. Levine et al.   LANGMUIR

Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis

(2013) Yuhua Wang et al.   MOLECULAR THERAPY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Liposome: classification, preparation, and applications

(2013) Abolfazl Akbarzadeh et al.   Nanoscale Research Letters

TLR8: the forgotten relative revindicated

(2012) Jorge L Cervantes et al.   Cellular & Molecular Immunology

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity

(2012) Jamie L Harden et al.   IMMUNOLOGICAL INVESTIGATIONS

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

siRNA and cancer immunotherapy

(2012) Soudeh Ghafouri-Fard et al.   Immunotherapy

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

The packaging of siRNA within the mesoporous structure of silica nanoparticles

(2011) Xu Li et al.   BIOMATERIALS

CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice

(2011) Jon Hansen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Optimized dextran–polyethylenimine conjugates are efficient non-viral vectors with reduced cytotoxicity when used in serum containing environments

(2011) Dahai Jiang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Progress and Outlook of Inorganic Nanoparticles for Delivery of Nucleic Acid Sequences Related to Orthopedic Pathologies: A Review

(2011) Darcy E. Wagner et al.   TISSUE ENGINEERING PART B-REVIEWS

Silencing or Stimulation? siRNA Delivery and the Immune System

(2011) Kathryn A. Whitehead et al.   Annual Review of Chemical and Biomolecular Engineering

Polymers in Small-Interfering RNA Delivery

(2011) Kaushik Singha et al.   Nucleic Acid Therapeutics

Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte

(2010) Shutao Guo et al.   ACS Nano

Toxicity Pathway Focused Gene Expression Profiling of PEI-Based Polymers for Pulmonary Applications

(2010) Andrea Beyerle et al.   MOLECULAR PHARMACEUTICS

Effective Gene Silencing by Multilayered siRNA-Coated Gold Nanoparticles

(2010) Seung Koo Lee et al.   Small

Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles

(2009) Katharina Ladewig et al.   APPLIED CLAY SCIENCE

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

(2009) Damià Tormo et al.   CANCER CELL

Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery

(2009) Asmaa Elbakry et al.   NANO LETTERS

RNA recognition and signal transduction by RIG-I-like receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNOLOGICAL REVIEWS

Polymeric Nanocarriers for siRNA Delivery: Challenges and Future Prospects

(2008) Dongmei Cun et al.   Journal of Biomedical Nanotechnology

Development of a novel endosomolytic diblock copolymer for siRNA delivery

(2008) Anthony J. Convertine et al.   JOURNAL OF CONTROLLED RELEASE

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

Efficient siRNA Delivery with Non-viral Polymeric Vehicles

(2008) Won Jong Kim et al.   PHARMACEUTICAL RESEARCH

Inorganic Nanoparticles as Carriers of Nucleic Acids into Cells

(2007) Viktoriya Sokolova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION