Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders

Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

(2016) Yan-Jie Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Targeting α-synuclein: Therapeutic options

(2016) Benjamin Dehay et al.   MOVEMENT DISORDERS

Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells

(2016) Xia-Fei Wang et al.   PLoS One

Effect of α-synuclein on membrane permeability and synaptic transmission: a clue to neurodegeneration?

(2015) Alexei Surguchev et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane

(2015) Carla R. Pacheco et al.   JOURNAL OF NEUROCHEMISTRY

Aβ1-42oligomer-induced leakage in anin vitroblood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins

(2015) Wenbin Wan et al.   JOURNAL OF NEUROCHEMISTRY

Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

(2015) Marjana Brkic et al.   MEDIATORS OF INFLAMMATION

Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson’s disease and in MPP+-treated MN9D cells in vitro

(2015) M. Sivasubramanian et al.   NEUROSCIENCE

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins

(2015) Magdalena Cieślik et al.   PLoS One

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT1 in the brain—connections with aging-associated disorders and lifespan

(2015) Fanny Ng   Frontiers in Cellular Neuroscience

In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis

(2014) Eleftherios Ouzounoglou et al.   BMC Systems Biology

Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate

(2014) Andreas V. Thuy et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Original article Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein

(2014) Henryk Jesko et al.   FOLIA NEUROPATHOLOGICA

Original article The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson’s disease

(2014) Joanna A. Pyszko et al.   FOLIA NEUROPATHOLOGICA

Sphingosine Kinase 1 and Sphingosine-1-Phosphate in Oxidative Stress Evoked by 1-Methyl-4-Phenylpyridinium (MPP+) in Human Dopaminergic Neuronal Cells

(2014) Joanna Pyszko et al.   MOLECULAR NEUROBIOLOGY

Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate

(2014) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Sphingosine-1-Phosphate and Its Effect on Glucose Deprivation/Glucose Reload Stress: From Gene Expression to Neuronal Survival

(2014) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Lipid Integration in Neurodegeneration: An Overview of Alzheimer’s Disease

(2014) Rajesh Singh Yadav et al.   MOLECULAR NEUROBIOLOGY

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells

(2014) Magdalena Gassowska et al.   NEUROCHEMICAL RESEARCH

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

(2014) Marie-France Langelier et al.   NUCLEIC ACIDS RESEARCH

Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on α-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain

(2014) Agata Adamczyk et al.   Pharmacological Reports

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

(2014) Seiji Watanabe et al.   Molecular Brain

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

(2014) Johnatan Ceccom et al.   Acta Neuropathologica Communications

Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro

(2013) Grzegorz A. Czapski et al.   FEBS LETTERS

Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration

(2013) Anna Wilkaniec et al.   NEUROCHEMISTRY INTERNATIONAL

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

(2013) Brad Kincaid et al.   Frontiers in Aging Neuroscience

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors

(2012) K. Alexa Orr Gandy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease

(2012) Joanna B. Strosznajder et al.   MOLECULAR NEUROBIOLOGY

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

(2012) Terina N Martinez et al.   Molecular Neurodegeneration

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

(2011) Péter Bai et al.   Cell Metabolism

Fine Tuning Our Cellular Factories: Sirtuins in Mitochondrial Biology

(2011) Lei Zhong et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

(2011) Bobby Thomas et al.   PLoS One

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

(2011) Evangelia Emmanouilidou et al.   PLoS One

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poly(ADP-Ribose) Metabolism in Brain and Its Role in Ischemia Pathology

(2010) Robert Piotr Strosznajder et al.   MOLECULAR NEUROBIOLOGY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus

(2010) T. Kanno et al.   NEUROSCIENCE

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

(2010) Joanne Clark et al.   PLoS One

Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology

(2009) Karin M. Danzer et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein and neuronal cell death

(2009) Mark R Cookson   Molecular Neurodegeneration

Erratum: Sirtuins — novel therapeutic targets to treat age-associated diseases

(2009) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Closer Look at α-Secretase

(2008) Rolf Postina   Current Alzheimer Research

α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells

(2008) Anna Kazmierczak et al.   NEUROCHEMISTRY INTERNATIONAL

Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage

(2007) F MORONI   CURRENT OPINION IN PHARMACOLOGY

α-Synuclein forms a complex with transcription factor Elk-1

(2003) Atsushi Iwata et al.   JOURNAL OF NEUROCHEMISTRY