Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort

(2014) Patrick Weydt et al.   BMC Neurology

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

(2014) Roberta Tufi et al.   NATURE CELL BIOLOGY

Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease

(2014) Falk Schlaudraff et al.   NEUROBIOLOGY OF AGING

Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis

(2014) Virginie Licker et al.   PROTEOMICS

Mitochondrial Abnormality Associates with Type-Specific Neuronal Loss and Cell Morphology Changes in the Pedunculopontine Nucleus in Parkinson Disease

(2013) Ilse S. Pienaar et al.   AMERICAN JOURNAL OF PATHOLOGY

PGC-1α, mitochondrial dysfunction, and Huntington's disease

(2013) Ashu Johri et al.   FREE RADICAL BIOLOGY AND MEDICINE

PGC-1  is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis

(2013) J. Eschbach et al.   HUMAN MOLECULAR GENETICS

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

(2012) Jorge L. Ruas et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

The Role of PGC-1α in the Pathogenesis of Neurodegenerative Disorders

(2012) Krisztina Rona-Voros et al.   CURRENT DRUG TARGETS

AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells

(2012) L. Fassina et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

(2012) Almas Siddiqui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset

(2012) Eliana Marisa Ramos et al.   HUMAN GENETICS

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset†

(2012) Selma M. Soyal et al.   HUMAN MOLECULAR GENETICS

Sustained expression of PGC-1  in the rat nigrostriatal system selectively impairs dopaminergic function

(2012) C. Ciron et al.   HUMAN MOLECULAR GENETICS

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

(2011) Ashu Johri et al.   HUMAN MOLECULAR GENETICS

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

(2011) Wei Zhao et al.   Molecular Neurodegeneration

Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

(2011) Hong Van B Che et al.   Molecular Neurodegeneration

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

(2011) Huiyun Liang et al.   MUSCLE & NERVE

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β2-adrenergic receptor activation

(2010) Miki Tadaishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative Stress in Parkinson's Disease

(2010) Chun Zhou et al.   Annals of the New York Academy of Sciences

Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues

(2010) Judith Eschbach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

(2010) Daniel J. Ho et al.   EXPERIMENTAL NEUROLOGY

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons

(2010) Kerstin E. Braunstein et al.   HUMAN MOLECULAR GENETICS

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

(2010) Ming-Chang Chiang et al.   HUMAN MOLECULAR GENETICS

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

(2010) R. K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

PGC-1α-induced improvements in skeletal muscle metabolism and insulin sensitivityThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) Arend Bonen   Applied Physiology Nutrition and Metabolism

Impaired PGC-1α function in muscle in Huntington's disease

(2009) Rajnish K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons

(2009) Przemyslaw Wareski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology

(2009) Karin M. Danzer et al.   JOURNAL OF NEUROCHEMISTRY

Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent  -Synuclein Oligomer Formation and Rescue  -Synuclein-Induced Toxicity

(2009) P. Putcha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The gene coding for PGC-1α modifies age at onset in Huntington's Disease

(2009) Patrick Weydt et al.   Molecular Neurodegeneration

PGC-1alpha as modifier of onset age in Huntington disease

(2009) Elahe Taherzadeh-Fard et al.   Molecular Neurodegeneration

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress Involvement in α-Synuclein Oligomerization in Parkinson's Disease Cybrids

(2008) A. Raquel Esteves et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

(2008) Rebecca Banerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One