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Title
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-01-13
DOI
10.3389/fphar.2020.585821
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- Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease
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- Sirtuins, Aging, and Medicine
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- Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
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- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
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- Mammalian Sirtuins: Biological Insights and Disease Relevance
- (2010) Marcia C. Haigis et al. Annual Review of Pathology-Mechanisms of Disease
- Protective Effect of Sesamol against 3-Nitropropionic Acid-Induced Cognitive Dysfunction and Altered Glutathione Redox Balance in Rats
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- SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest
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- Role of Sirtuin 1 in metabolic regulation
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- Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease
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- SIRT1 Activation by Small Molecules
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- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
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- Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease
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- SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
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- Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
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- A Combination Therapy of Donepezil and Cilostazol for Patients With Moderate Alzheimer Disease: Pilot Follow-Up Study
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- Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors
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- Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
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- SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology
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- Impaired PGC-1α function in muscle in Huntington's disease
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- Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity
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- Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)
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- The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide
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- CBP/p300-mediated acetylation of histone H3 on lysine 56
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- An Overview of APP Processing Enzymes and Products
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- Sirt2 interacts with 14-3-3 β/γ and down-regulates the activity of p53
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- Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator
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- Biological and Potential Therapeutic Roles of Sirtuin Deacetylases
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- Resveratrol: A Natural Compound with Pharmacological Potential in Neurodegenerative Diseases
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- Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease
- (2008) Judit Pallos et al. HUMAN MOLECULAR GENETICS
- The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
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- Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
- (2008) Carl Julien et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau
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- The SIRT2 Deacetylase Regulates Autoacetylation of p300
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- Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK
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