Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

(2018) Xiu‐Fei Chen et al.   EMBO REPORTS

Potent and Selective Inhibitors of Human Sirtuin 5

(2018) Diana Kalbas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

(2018) Yun-Qian Wang et al.   Nature Communications

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

(2018) Kiran Kurmi et al.   Cell Reports

Targeting a Sirt5-Positive Subpopulation Overcomes Multidrug Resistance in Wild-Type Kras Colorectal Carcinomas

(2018) ZunGuo Du et al.   Cell Reports

Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain

(2018) Kevin B. Koronowski et al.   Frontiers in Neuroscience

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain

(2017) Yuxun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

(2017) Kathleen A. Hershberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Analysis of Polymorphisms in 58 Potential Candidate Genes for Association with Human Longevity

(2017) Timothy A Donlon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

(2017) Kathleen A. Hershberger et al.   Nature Reviews Nephrology

Database resources of the National Center for Biotechnology Information

(2017) et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial fusion, fission, and mitochondrial toxicity

(2017) Joel N. Meyer et al.   TOXICOLOGY

For Certain, SIRT4 Activities!

(2017) Surinder Kumar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cycling around Lysine Modifications

(2017) Surinder Kumar et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sirtuin Inhibition: Strategies, Inhibitors, and Therapeutic Potential

(2017) Yanhong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

(2017) Martin Pannek et al.   Nature Communications

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Protein post-translational modifications: In silico prediction tools and molecular modeling

(2017) Martina Audagnotto et al.   Computational and Structural Biotechnology Journal

A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes

(2016) Wesley Wei Wang et al.   ACS Chemical Biology

SIRT7 Is an RNA-Activated Protein Lysine Deacylase

(2016) Zhen Tong et al.   ACS Chemical Biology

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Using mitochondrial sirtuins as drug targets: disease implications and available compounds

(2016) Melanie Gertz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

(2016) O. Clark et al.   CLINICAL CANCER RESEARCH

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

High-throughput screening of Sirtuin family of genes in breast cancer

(2016) Mehri Igci et al.   GENE

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

(2016) Andreas S. Madsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Selective Cyclic Peptidic Human SIRT5 Inhibitor

(2016) Jiajia Liu et al.   MOLECULES

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells

(2016) Fengyi Liang et al.   NEUROTOXICITY RESEARCH

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2

(2016) Fengling Li et al.   Frontiers in Cellular Neuroscience

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

(2016) Sifan Chen et al.   Nature Communications

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

(2016) Ye Xiangyun et al.   Oncotarget

Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5

(2016) Kahlilia C. Morris-Blanco et al.   Scientific Reports

Sirt1 activation by resveratrol is substrate sequence-selective

(2016) Mahadevan Lakshminarasimhan et al.   Aging-US

STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism

(2016) Yan S. Xu et al.   Scientific Reports

Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples

(2015) Erik D. Guetschow et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer

(2015) Surinder Kumar et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT5 regulation of ammonia-induced autophagy and mitophagy

(2015) Lucia Polletta et al.   Autophagy

Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease

(2015) Lei Liu et al.   BEHAVIOURAL BRAIN RESEARCH

A FRET-based assay for screening SIRT5 specific modulators

(2015) Yan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel thiourea-based sirtuin inhibitory warheads

(2015) Wenwen Zang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

SIRT5 prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3

(2015) Yongfeng Wang et al.   CELL STRESS & CHAPERONES

Acetyl-ed question in mitochondrial biology?

(2015) D. B. Lombard et al.   EMBO JOURNAL

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

(2015) B. T. Weinert et al.   EMBO JOURNAL

A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases

(2015) Claudia Roessler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the cardiac succinylome and its role in ischemia–reperfusion injury

(2015) Jennifer A. Boylston et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

(2015) Gozde Colak et al.   MOLECULAR & CELLULAR PROTEOMICS

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

(2015) Matthew D. Hirschey et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

(2015) Feng Li et al.   MOLECULAR CELL

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

(2015) Edyta Marcon et al.   NATURE METHODS

Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium

(2015) Carla Bartosch et al.   Oncotarget

SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer

(2015) Xiao-bin Lv et al.   Scientific Reports

Membrane microenvironment regulation of carnitine palmitoyltranferases I and II

(2015) Khosrow Kashfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase

(2015) Yuxun Zhang et al.   PLoS One

Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies

(2015) Yan-Bin Teng et al.   Scientific Reports

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors

(2014) Claudia Roessler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Promising roles of mammalian E2Fs in hepatocellular carcinoma

(2014) Lei Zhan et al.   CELLULAR SIGNALLING

SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism

(2014) Marcin Buler et al.   FASEB JOURNAL

Protein Kinase C Epsilon Regulates Mitochondrial Pools of Nampt and NAD Following Resveratrol and Ischemic Preconditioning in the Rat Cortex

(2014) Kahlilia C Morris-Blanco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

(2014) Gregory R. Wagner et al.   MOLECULAR CELL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort

(2014) Mindi J. TenNapel et al.   PLoS One

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer

(2014) Weidong Lu et al.   TUMOR BIOLOGY

Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death

(2014) D Guan et al.   Cell Death & Disease

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

SIRT5: A Safeguard Against Oxidative Stress-Induced Apoptosis in Cardiomyocytes

(2013) Ban Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cloning, chromosomal characterization and FISH mapping of the NAD+-dependent histone deacetylase gene sirtuin 5 in the mouse

(2013) SUSANNE VOELTER-MAHLKNECHT et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age

(2013) Leanne Pacella-Ince et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Altered expression of SIRT gene family in head and neck squamous cell carcinoma

(2013) Chi-Chih Lai et al.   TUMOR BIOLOGY

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

(2013) David Rauh et al.   Nature Communications

Metabolic Characterization of a Sirt5 deficient mouse model

(2013) Jiujiu Yu et al.   Scientific Reports

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

ATP-citrate lyase: A mini-review

(2012) Melanie Chypre et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074

(2012) Benjamin Suenkel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Histone Deacetylase Inhibitors Demonstrate Significant Preclinical Activity as Single Agents, and in Combination with Bortezomib in Waldenström's Macroglobulinemia

(2012) Jenny Y. Sun et al.   Clinical Lymphoma Myeloma & Leukemia

SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice

(2012) Yasuhiko Nakamura et al.   FEBS LETTERS

Thiosuccinyl Peptides as Sirt5-Specific Inhibitors

(2012) Bin He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

(2012) Frank Fischer et al.   PLoS One

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

Inhibitors of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5

(2012) Benjamin Maurer et al.   ACS Medicinal Chemistry Letters

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Proteomic analysis of mitochondrial proteins in cardiomyocytes from rats subjected to intermittent hypoxia

(2011) Wei-Zhong Zhu et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction

(2011) Yi-Qun Geng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Signal Transducers and Activators of Transcription: STATs-Mediated Mitochondrial Neuroprotection

(2010) Hung Wen Lin et al.   ANTIOXIDANTS & REDOX SIGNALING

Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1

(2010) Masahito Ogura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Functional Characterization of the Recombinant Human Mitochondrial Trifunctional Protein

(2010) Benjamin Fould et al.   BIOCHEMISTRY

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

(2010) Nobuko Matsushita et al.   GENES TO CELLS

Neuronal Protective Role of PBEF in a Mouse Model of Cerebral Ischemia

(2010) Weiping Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

(2010) Christin Glorioso et al.   NEUROBIOLOGY OF DISEASE

Post-ischemic activation of protein kinase C epsilon protects the hippocampus from cerebral ischemic injury via alterations in cerebral blood flow

(2010) D. Della-Morte et al.   NEUROSCIENCE LETTERS

Uric acid and evolution

(2010) B. Alvarez-Lario et al.   RHEUMATOLOGY

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel

(2009) Kunjan R. Dave et al.   JOURNAL OF NEUROCHEMISTRY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

The human SIRT3 protein deacetylase is exclusively mitochondrial

(2008) Helen M. Cooper et al.   BIOCHEMICAL JOURNAL

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Ischemic Preconditioning Targets the Respiration of Synaptic Mitochondria via Protein Kinase C 

(2008) K. R. Dave et al.   JOURNAL OF NEUROSCIENCE

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

(2008) William F. Hawse et al.   STRUCTURE