Systemic regulation of mammalian ageing and longevity by brain sirtuins

Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner

(2016) Rachel Whitaker et al.   Aging-US

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis

(2013) Jose Monteserin-Garcia et al.   FASEB JOURNAL

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues

(2013) Min Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action

(2013) D. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Chinese agriculture: An experiment for the world

(2013) Fusuo Zhang et al.   NATURE

FGF21 contributes to neuroendocrine control of female reproduction

(2013) Bryn M Owen et al.   NATURE MEDICINE

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Oxidative stress and the ageing endocrine system

(2013) Giovanni Vitale et al.   Nature Reviews Endocrinology

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells

(2013) Yexin Li et al.   NEUROSCIENCE LETTERS

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Sirtuins in neurodegenerative diseases: an update on potential mechanisms

(2013) Sang-Won Min et al.   Frontiers in Aging Neuroscience

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

(2013) Liou Y Sun et al.   eLife

Anorexia of Aging and Gut Hormones

(2013) Deniz Atalayer et al.   Aging and Disease

Deviation of innate circadian period from 24 h reduces longevity in mice

(2012) Sergiy Libert et al.   AGING CELL

Sirtuin activators and inhibitors

(2012) José M. Villalba et al.   BIOFACTORS

Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

(2012) Zachary A. Knight et al.   CELL

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

(2012) Jun Yoshino et al.   Cell Metabolism

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Natural genetic variation in yeast longevity

(2012) S. W. Stumpferl et al.   GENOME RESEARCH

SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

(2012) Chu-Xia Deng   International Journal of Biological Sciences

Necdin Controls Foxo1 Acetylation in Hypothalamic Arcuate Neurons to Modulate the Thyroid Axis

(2012) K. Hasegawa et al.   JOURNAL OF NEUROSCIENCE

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

(2012) Luca Tiberi et al.   NATURE NEUROSCIENCE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

(2012) Kushal Kr. Banerjee et al.   Cell Reports

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Sir2 deletion prevents lifespan extension in 32 long-lived mutants

(2011) Joe R. Delaney et al.   AGING CELL

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

(2011) Sergiy Libert et al.   CELL

Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity

(2011) Pei-Ting Chao et al.   Cell Metabolism

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance

(2011) Giorgio Ramadori et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons

(2011) L. Panossian et al.   JOURNAL OF NEUROSCIENCE

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Age-related loss of orexin/hypocretin neurons

(2011) B.A. Kessler et al.   NEUROSCIENCE

Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture

(2011) Sun Hee Kim et al.   PLoS One

Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function

(2011) Dongmei Wu et al.   PLoS One

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Anterior Cingulate Activation Is Related to a Positivity Bias and Emotional Stability in Successful Aging

(2010) Stefanie Brassen et al.   BIOLOGICAL PSYCHIATRY

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

(2010) Giorgio Ramadori et al.   Cell Metabolism

Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide

(2010) Tsutomu Sasaki et al.   ENDOCRINOLOGY

Age-associated changes of appetite-regulating peptides

(2010) Saeko Akimoto et al.   Geriatrics & Gerontology International

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus

(2010) A. Satoh et al.   JOURNAL OF NEUROSCIENCE

Role of Pax3 acetylation in the regulation of Hes1 and Neurog2

(2010) Shunsuke Ichi et al.   MOLECULAR BIOLOGY OF THE CELL

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

(2010) Albert Y. Sun et al.   MOLECULAR NEUROBIOLOGY

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

A possibility of nutriceuticals as an anti-aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis

(2010) Shin-ichiro Imai   PHARMACOLOGICAL RESEARCH

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals

(2010) Sayaka Akieda-Asai et al.   PLoS One

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

(2010) B. Schwer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity

(2009) Yingjia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice

(2009) Takahiro Moriya et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

(2009) D. E. Cohen et al.   GENES & DEVELOPMENT

Developmental and aging change of orexin-A and -B immunoreactive neurons in the male rat hypothalamus

(2009) Nobuhiko Sawai et al.   NEUROSCIENCE LETTERS

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling1

(2008) Ullas Kolthur-Seetharam et al.   BIOLOGY OF REPRODUCTION

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

(2008) Timour Prozorovski et al.   NATURE CELL BIOLOGY

Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function

(2008) Matthew Coussens et al.   PLoS One

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA