Mitochondrial sirtuins - a new therapeutic target for repair and protection in multiple sclerosis

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

SirT1 brings stemness closer to cancer and aging

(2016) Vincenzo Calvanese et al.   Aging-US

Sirtuins and Disease: The Road Ahead

(2012) Vincenzo Carafa et al.   Frontiers in Pharmacology

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2011) Jone López-Erauskin et al.   ANNALS OF NEUROLOGY

PPARα–LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status

(2011) Paul W. Caton et al.   BIOCHEMICAL JOURNAL

Redox regulation of cellular stress response in multiple sclerosis

(2011) G. Pennisi et al.   BIOCHEMICAL PHARMACOLOGY

Newly lesioned tissue in multiple sclerosis--a role for oxidative damage?

(2011) K. J. Smith   BRAIN

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications

(2011) Christine Stadelmann   CURRENT OPINION IN NEUROLOGY

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Peroxisome proliferator-activated receptor-α agonists protect cortical neurons from inflammatory mediators and improve peroxisomal function

(2011) Elizabeth Gray et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The molecular basis of neurodegeneration in multiple sclerosis

(2011) Hans Lassmann et al.   FEBS LETTERS

Protein Misfolding and Oxidative Stress Promote Glial-Mediated Neurodegeneration in an Alexander Disease Model

(2011) L. Wang et al.   JOURNAL OF NEUROSCIENCE

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

Mitochondrial changes associated with demyelination: Consequences for axonal integrity

(2011) Graham R. Campbell et al.   MITOCHONDRION

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis

(2011) Melis Karaca et al.   NEUROCHEMISTRY INTERNATIONAL

Age and disability accumulation in multiple sclerosis

(2011) A. Scalfari et al.   NEUROLOGY

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture

(2011) Sun Hee Kim et al.   PLoS One

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

(2011) Jorg van Loosdregt et al.   PLoS One

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

S-Nitrosylation of Critical Protein Thiols Mediates Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Tomohiro Nakamura et al.   ANTIOXIDANTS & REDOX SIGNALING

Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1

(2010) Masahito Ogura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuins and inflammation: Friends or foes?

(2010) Mara Gallí et al.   BIOCHEMICAL PHARMACOLOGY

Radical changes in multiple sclerosis pathogenesis

(2010) Jack van Horssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic potential of activators and inhibitors of sirtuins

(2010) Aneta Balcerczyk et al.   BIOFACTORS

Neuroprotective properties of resveratrol in different neurodegenerative disorders

(2010) Diego Albani et al.   BIOFACTORS

SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

(2010) X. Ou et al.   BLOOD

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets

(2010) Mahadevan Lakshminarasimhan et al.   EXPERIMENTAL GERONTOLOGY

SIRT1 contributes to telomere maintenance and augments global homologous recombination

(2010) Jose A. Palacios et al.   JOURNAL OF CELL BIOLOGY

Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria

(2010) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells

(2010) Tong SHI et al.   Journal of Digestive Diseases

Oral Resveratrol Reduces Neuronal Damage in a Model of Multiple Sclerosis

(2010) Kenneth S Shindler et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death

(2010) Jae-Suk Seo et al.   NEUROBIOLOGY OF AGING

Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

(2010) Christin Glorioso et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection and brain cholesterol biosynthesis in Huntington's disease

(2010) M. Valenza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirtuin 1 regulation of developmental genes during differentiation of stem cells

(2010) V. Calvanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy metabolism in adult neural stem cell fate

(2010) Victoria A. Rafalski et al.   PROGRESS IN NEUROBIOLOGY

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Calorie restriction alters mitochondrial protein acetylation

(2009) Bjoern Schwer et al.   AGING CELL

The Role of Sirtuins in the Control of Metabolic Homeostasis

(2009) Jiujiu Yu et al.   Annals of the New York Academy of Sciences

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

Is multiple sclerosis a mitochondrial disease?

(2009) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structural basis for sirtuin function: What we know and what we don't

(2009) Brandi D. Sanders et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

(2009) J. van Loosdregt et al.   BLOOD

Mitochondrial changes within axons in multiple sclerosis

(2009) D. J. Mahad et al.   BRAIN

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Panaxynol protects cortical neurons from ischemia-like injury by up-regulation of HIF-1α expression and inhibition of apoptotic cascade

(2009) Zhi-hui Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology

(2009) Kai Harting et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

NAD+-dependent Deacetylase SIRT3 Regulates Mitochondrial Protein Synthesis by Deacetylation of the Ribosomal Protein MRPL10

(2009) Yongjie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survival

(2009) Kevin Kemp et al.   JOURNAL OF NEUROCHEMISTRY

Enhanced number and activity of mitochondria in multiple sclerosis lesions

(2009) Maarten E Witte et al.   JOURNAL OF PATHOLOGY

Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation

(2009) Jiujiu Yu et al.   PHARMACOLOGICAL RESEARCH

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins

(2009) Ivy K. M. Law et al.   PROTEOMICS

Regulation of proteins mediating neurodegeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

(2009) Archana M. Jastorff et al.   Proteomics Clinical Applications

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Regulation of SIRT1 protein levels by nutrient availability

(2008) Yariv Kanfi et al.   FEBS LETTERS

Regulation of SIRT6 protein levels by nutrient availability

(2008) Yariv Kanfi et al.   FEBS LETTERS

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

(2008) S. Fourcade et al.   HUMAN MOLECULAR GENETICS

Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis

(2008) Laura Piccio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Variations in Mitochondrial DNA Copy Numbers in MS Brains

(2008) Andrei Blokhin et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism

(2008) Mariola Matysiak et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity

(2008) R.E. Gonsette   JOURNAL OF THE NEUROLOGICAL SCIENCES

Transketolase and 2′,3′-Cyclic-nucleotide 3′-Phosphodiesterase Type I Isoforms Are Specifically Recognized by IgG Autoantibodies in Multiple Sclerosis Patients

(2008) Laura Lovato et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

(2008) Timour Prozorovski et al.   NATURE CELL BIOLOGY

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

(2008) Siming Shen et al.   NATURE NEUROSCIENCE

Investigation of the Role of Mitochondrial DNA in Multiple Sclerosis Susceptibility

(2008) Maria Ban et al.   PLoS One

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

(2008) S. Hisahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated Activity and Microglial Expression of Myeloperoxidase in Demyelinated Cerebral Cortex in Multiple Sclerosis

(2007) Elizabeth Gray et al.   BRAIN PATHOLOGY

SIRT2, tubulin deacetylation, and oligodendroglia differentiation

(2007) Bor Luen Tang et al.   CELL MOTILITY AND THE CYTOSKELETON