Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype

(2016) Xianghui Zou et al.   ANTIOXIDANTS & REDOX SIGNALING

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

(2016) Stephan Winnik et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

Role ofSirt3in mitochondrial biogenesis and developmental competence of humanin vitromatured oocytes

(2016) Hong-Cui Zhao et al.   HUMAN REPRODUCTION

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat

(2016) Mahua Choudhury et al.   Aging-US

The sirtuins, oxidative stress and aging: an emerging link

(2016) Philip I. Merksamer et al.   Aging-US

Nuclear respiratory factor 2 induces SIRT3 expression

(2015) F. Kyle Satterstrom et al.   AGING CELL

Sirtuins: double players in Huntington's disease

(2015) Luana Naia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection

(2014) Jia-Xing Wang et al.   BMC CANCER

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

(2014) Roxane Paulin et al.   Cell Metabolism

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer

(2014) Mohamed Mokhtar Desouki et al.   HUMAN PATHOLOGY

SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma

(2014) Shu-Mei Yan et al.   MEDICAL ONCOLOGY

Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer

(2013) Yue Zhao et al.   Annals of Diagnostic Pathology

Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer

(2013) Bing Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells

(2013) Li Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuins as therapeutic targets of ALS

(2013) Giulio Maria Pasinetti et al.   CELL RESEARCH

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Protein Deacetylase SIRT3 Prevents Oxidative Stress-induced Keratinocyte Differentiation

(2013) Alexandra S. Bause et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STRESS-Responsive Deacetylase SIRT3 is Up-Regulated by Areca Nut Extract-Induced Oxidative Stress in Human Oral Keratinocytes

(2013) I-Chieh Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effect of near-infrared light exposure on mitochondrial signaling in C2C12 muscle cells

(2013) Linda M.-D. Nguyen et al.   MITOCHONDRION

SIRT3 Expression as a Biomarker for Better Prognosis in Gastric Cancer

(2013) Kuo-Hung Huang et al.   WORLD JOURNAL OF SURGERY

SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells

(2013) Bo Zhang et al.   Asian Pacific Journal of Tropical Medicine

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

(2013) Y Cheng et al.   Cell Death & Disease

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

(2013) Brad Kincaid et al.   Frontiers in Aging Neuroscience

Emerging beneficial roles of sirtuins in heart failure

(2012) Masaya Tanno et al.   BASIC RESEARCH IN CARDIOLOGY

Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation

(2012) Yuan-Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

(2012) Jinrong Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

(2012) Amrita Bose et al.   PLoS One

CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease

(2012) Heather J. M. Weir et al.   PLoS One

Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma

(2012) Chris Zhiyi Zhang et al.   PLoS One

SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

(2011) Paul T. Schumacker   CANCER CELL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Oncogenic Pathways, Molecularly Targeted Therapies, and Highlighted Clinical Trials in Non–Small-Cell Lung Cancer (NSCLC)

(2011) Thanyanan Reungwetwattana et al.   Clinical Lung Cancer

Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells

(2011) Diana M Vallejo et al.   EMBO JOURNAL

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis

(2011) Seong-Hoon Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of theSirt3Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

(2011) Albert Giralt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SirT3 Divining Rod Points to Oxidative Stress

(2011) Eric L. Bell et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture

(2011) Sun Hee Kim et al.   PLoS One

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

A Tumor Suppressor SIRTainty

(2010) Paul T. Schumacker   CANCER CELL

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Mitochondrial SIRT3 and heart disease

(2010) V. B. Pillai et al.   CARDIOVASCULAR RESEARCH

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Mitochondrial DNA transmission, replication and inheritance: a journey from the gamete through the embryo and into offspring and embryonic stem cells

(2010) J. C. St. John et al.   HUMAN REPRODUCTION UPDATE

Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles

(2010) Fumi Hokari et al.   JOURNAL OF APPLIED PHYSIOLOGY

Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest

(2010) Yumiko Kawamura et al.   JOURNAL OF CLINICAL INVESTIGATION

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

p53-Induced Growth Arrest Is Regulated by the Mitochondrial SirT3 Deacetylase

(2010) SiDe Li et al.   PLoS One

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

Regulation of superoxide dismutase genes: Implications in disease

(2009) Lu Miao et al.   FREE RADICAL BIOLOGY AND MEDICINE

NAD+-dependent Deacetylase SIRT3 Regulates Mitochondrial Protein Synthesis by Deacetylation of the Ribosomal Protein MRPL10

(2009) Yongjie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of GATA2 and AP-1 Activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene

(2009) Dina Bellizzi et al.   MOLECULES AND CELLS

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity

(2009) Tingting Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Genetic Variation in Healthy Oldest-Old

(2009) Julius Halaschek-Wiener et al.   PLoS One

The human SIRT3 protein deacetylase is exclusively mitochondrial

(2008) Helen M. Cooper et al.   BIOCHEMICAL JOURNAL

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Mechanisms and Molecular Probes of Sirtuins

(2008) Brian C. Smith et al.   CHEMISTRY & BIOLOGY

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5

(2007) Yasuhiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS