Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells

Modulation of death receptors by cancer therapeutic agents

(2010) Heath A. Elrod et al.   CANCER BIOLOGY & THERAPY

Structure of the Fas/FADD complex: A conditional death domain complex mediating signaling by receptor clustering

(2010) Guy S. Salvesen et al.   CELL CYCLE

ERK/Ribosomal S6 Kinase (RSK) Signaling Positively Regulates Death Receptor 5 Expression through Co-activation of CHOP and Elk1

(2010) You-Take Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway

(2010) Weiping Yu et al.   MOLECULAR CARCINOGENESIS

Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis

(2010) Richa Tiwary et al.   PLoS One

Recent advances in histone deacetylase targeted cancer therapy

(2010) Isamu Hoshino et al.   SURGERY TODAY

ATF3 transcription factor and its emerging roles in immunity and cancer

(2009) Matthew R. Thompson et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis

(2008) Martina Korfei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Coupling of Endoplasmic Reticulum Stress to CDDO-Me-Induced Up-regulation of Death Receptor 5 via a CHOP-Dependent Mechanism Involving JNK Activation

(2008) W. Zou et al.   CANCER RESEARCH

Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway

(2008) L Turchi et al.   CELL DEATH AND DIFFERENTIATION

Inhibitors of NAD+ Dependent Histone Deacetylases (Sirtuins)

(2008) Manfred Jung et al.   CURRENT PHARMACEUTICAL DESIGN

KLF6 Induces Apoptosis in Prostate Cancer Cells through Up-regulation of ATF3

(2008) Xiangwei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene

(2008) Nan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

(2008) E Lara et al.   ONCOGENE