Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

Challenges Associated with Metal Chelation Therapy in Alzheimer's Disease

(2017) Muralidhar L. Hegde et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β as a Modulator of Synaptic Plasticity

(2017) Mordhwaj S. Parihar et al.   JOURNAL OF ALZHEIMERS DISEASE

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

(2015) Jian Jeffrey Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin

(2015) Martin Pettersson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide

(2015) Ashim Paul et al.   CHEMICAL COMMUNICATIONS

Inhibition of protein aggregation and amyloid formation by small molecules

(2015) Andrew J Doig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

New Insights in Amyloid Beta Interactions with Human Telomerase

(2015) Jiasi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice

(2015) Daijiro Yanagisawa et al.   NEUROBIOLOGY OF AGING

Immunotherapeutic Approaches for Alzheimer’s Disease

(2015) Thomas Wisniewski et al.   NEURON

A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

(2015) Michael W. Beck et al.   Chemical Science

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

(2015) Jin Hu et al.   PLoS One

Rationally Designed Peptidomimetic Modulators of Aβ Toxicity in Alzheimer's Disease

(2015) K. Rajasekhar et al.   Scientific Reports

Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

(2015) Wen-Jie Du et al.   Scientific Reports

Transthyretin-Derived Peptides as β-Amyloid Inhibitors

(2014) Patricia Y. Cho et al.   ACS Chemical Neuroscience

First Selective Dual Inhibitors of Tau Phosphorylation and Beta-Amyloid Aggregation, Two Major Pathogenic Mechanisms in Alzheimer’s Disease

(2014) Marica Mariano et al.   ACS Chemical Neuroscience

Rationally Designed Peptoids Modulate Aggregation of Amyloid-Beta 40

(2014) J. Phillip Turner et al.   ACS Chemical Neuroscience

2014 Alzheimer's disease facts and figures

(2014)   Alzheimers & Dementia

Significant Structural Differences between Transient Amyloid-β Oligomers and Less-Toxic Fibrils in Regions Known To Harbor Familial Alzheimer′s Mutations

(2014) Bidyut Sarkar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The C-Terminal Threonine of Aβ43 Nucleates Toxic Aggregation via Structural and Dynamical Changes in Monomers and Protofibrils

(2014) Alexander E. Conicella et al.   BIOCHEMISTRY

Mechanism of Amyloid-β Fibril Elongation

(2014) Thomas Gurry et al.   BIOCHEMISTRY

Solid-state NMR sequential assignment of Osaka-mutant amyloid-beta (Aβ1−40 E22Δ) fibrils

(2014) Matthias Huber et al.   Biomolecular NMR Assignments

Anilinotriazoles as potent gamma secretase modulators

(2014) Adriana I. Velter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Cyclic Peptides as Inhibitors of Amyloid Fibrillation

(2014) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure–activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization

(2014) Julia Kaffy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein

(2014) Shinichiro Fuse et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2-Pyridyl-benzimidazole Iridium(III), Ruthenium(II), and Platinum(II) Complexes. Study of the Activity as Inhibitors of Amyloid-β Aggregation and Neurotoxicity Evaluation

(2014) Gorakh S. Yellol et al.   INORGANIC CHEMISTRY

Intromitochondrial IκB/NF-κB signaling pathway is involved in amyloid β peptide-induced mitochondrial dysfunction

(2014) Chun Shi et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species

(2014) Jennifer Mayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capturing a Reactive State of Amyloid Aggregates

(2014) Sudhakar Parthasarathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation

(2014) Luiza M.F. Gomes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Discovery of 7-Tetrahydropyran-2-yl Chromans: β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β-Protein (Aβ) in the Central Nervous System

(2014) Allen A. Thomas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

(2014) Oleg Epstein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid β Regulates the Expression and Function of AIP1

(2014) Huaiming Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Fibrils: Formation, Polymorphism, and Inhibition

(2014) Torleif Härd   Journal of Physical Chemistry Letters

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

(2014) Meng Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

(2014) S Sakura Minami et al.   NATURE MEDICINE

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol

(2014) Fei Mao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?

(2014) Paul Carrillo-Mora et al.   Oxidative Medicine and Cellular Longevity

Local interactions influence the fibrillation kinetics, structure and dynamics of Aβ(1–40) but leave the general fibril structure unchanged

(2014) Juliane Adler et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

(2014) Nicholas J. Izzo et al.   PLoS One

Feasibility of β-Sheet Breaker Peptide-H102 Treatment for Alzheimer's Disease Based on β-Amyloid Hypothesis

(2014) Lai-xiang Lin et al.   PLoS One

The relationship between amyloid structure and cytotoxicity

(2014) Karen E Marshall et al.   Prion

Clioquinol promotes the degradation of metal-dependent amyloid-  (A ) oligomers to restore endocytosis and ameliorate A  toxicity

(2014) K. E. S. Matlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular selection of peptide inhibitors that target disulphide-bridged Aβ42oligomers

(2014) Nicola Acerra et al.   PROTEIN SCIENCE

Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

(2014) Linda Lee et al.   Scientific Reports

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease

(2014) Kelly Willemijn Menting et al.   Frontiers in Aging Neuroscience

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Aβ42-Binding Peptoids as Amyloid Aggregation Inhibitors and Detection Ligands

(2013) Yuan Luo et al.   ACS Chemical Neuroscience

Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

(2013) Qiuming Wang et al.   ACS Chemical Neuroscience

Therapeutic induction of autophagy to modulate neurodegenerative disease progression

(2013) Warren E Hochfeld et al.   ACTA PHARMACOLOGICA SINICA

ACU-193: A candidate therapeutic antibody that selectively targets soluble beta-amyloid oligomers

(2013) Grant Krafft et al.   Alzheimers & Dementia

SAR228810: An antiprotofibrillar beta-amyloid antibody designed to reduce risk of amyloid-related imaging abnormalities (ARIA)

(2013) Laurent Pradier et al.   Alzheimers & Dementia

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

(2013) Laure-Estelle Cassagnes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Design and synthesis of novel 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines as small molecule BACE-1 inhibitors

(2013) Nima Razzaghi-Asl et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phenylimino-2 H -chromen-3-carboxamide derivatives as novel small molecule inhibitors of β-secretase (BACE1)

(2013) Najmeh Edraki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease

(2013) Jian Jeffrey Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

(2013) Bruno Alies et al.   CHEMICAL COMMUNICATIONS

A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

(2013) Masha G. Savelieff et al.   CHEMICAL COMMUNICATIONS

Inhibiting and Reversing Amyloid-β Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues

(2013) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications

(2013) Yuzhong Liu et al.   INORGANIC CHEMISTRY

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

(2013) Nikolay Pozdnyakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

(2013) Hans Hilpert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

(2013) Kevin W. Hunt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

(2013) Jing Yuan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

(2013) Chuanjun Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aβ40 modulates GABAAreceptor α6 subunit expression and rat cerebellar granule neuron maturation through the ERK/mTOR pathway

(2013) Xiao-Qin Zhan et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-  Production in an Alzheimer's Disease Mouse Model

(2013) J. H. Herskowitz et al.   JOURNAL OF NEUROSCIENCE

Theβ-sheet breakers and π-stacking

(2013) Adam Jarmuła et al.   JOURNAL OF PEPTIDE SCIENCE

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice

(2013) Jing Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity

(2013) Anuj K. Sharma et al.   Metallomics

Autophagy Modulation for Alzheimer’s Disease Therapy

(2013) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Amyloid β Peptides Promote Autophagy-Dependent Differentiation of Mouse Neural Stem Cells

(2013) Maria B. Fonseca et al.   MOLECULAR NEUROBIOLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

β-Amyloid-evoked Apoptotic Cell Death is Mediated Through MKK6–p66shc Pathway

(2013) Muneesa Bashir et al.   NEUROMOLECULAR MEDICINE

A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

(2013) Vadivel Parthsarathy et al.   PLoS One

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining intracellular selection with protein-fragment complementation to derive A  interacting peptides

(2013) N. Acerra et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

(2013) Akiko Kochi et al.   Chemical Science

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Synthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhancer

(2013) Kolla Rajasekhar et al.   ChemPlusChem

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

Kinetic studies of inhibition of the amyloid beta (1–42) aggregation using a ferrocene-tagged β-sheet breaker peptide

(2012) Lin Zhang et al.   ANALYTICAL BIOCHEMISTRY

An Asymmetric Dimer as the Basic Subunit in Alzheimer’s Disease Amyloid β Fibrils

(2012) Juan Miguel Lopez del Amo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Antioxidant role of amyloid β protein in cell-free and biological systems: implication for the pathogenesis of Alzheimerdisease

(2012) Maitrayee Sinha et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Toxicity of Amyloid ß Oligomers

(2012) Li Na Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Solid-state NMR Reveals a Close Structural Relationship between Amyloid-β Protofibrils and Oligomers

(2012) Holger A. Scheidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylations of Tryptophan-Modified Naphthoquinone Affect Its Inhibitory Potential toward Aβ Aggregation

(2012) Roni Scherzer-Attali et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Telomere Shortening and Alzheimer’s Disease

(2012) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Alzheimer Aβ peptide interactions with lipid membranes

(2012) Florentina Tofoleanu et al.   Prion

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Metal ions, Alzheimer's disease and chelation therapy

(2011) Ana Budimir   ACTA PHARMACEUTICA

Strategic Role for Mitochondria in Alzheimer's Disease and Cancer

(2011) Louise Hedskog et al.   ANTIOXIDANTS & REDOX SIGNALING

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Structural Model of Aβ40Fibrils

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heme–Cu Bound Aβ Peptides: Spectroscopic Characterization, Reactivity, and Relevance to Alzheimer’s Disease

(2011) Debajyoti Pramanik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical modulators of autophagy as biological probes and potential therapeutics

(2010) Angeleen Fleming et al.   Nature Chemical Biology

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta mediates memory formation

(2009) A. Garcia-Osta et al.   LEARNING & MEMORY

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Multipotent natural agents to combat Alzheimer's disease. Functional spectrum and structural features

(2008) Hong-fang JI et al.   ACTA PHARMACOLOGICA SINICA

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

The toxicology of Clioquinol☆

(2008) X MAO et al.   TOXICOLOGY LETTERS