Recent advances for cancer detection and treatment by microfluidic technology, review and update

Emerging Advances of Detection Strategies for Tumor-Derived Exosomes

(2022) Huijuan Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A CRISPR/Cas13a-powered catalytic electrochemical biosensor for successive and highly sensitive RNA diagnostics

(2021) Yan Sheng et al.   BIOSENSORS & BIOELECTRONICS

Microfluidics for Liquid Biopsies: Recent Advances, Current Challenges, and Future Directions

(2021) Yuri Belotti et al.   ANALYTICAL CHEMISTRY

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

(2021) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

A novel tumor-immune microenvironment (TIME)-on-Chip mimics three dimensional neutrophil-tumor dynamics and neutrophil extracellalar traps (NETs)- mediated collective tumor invasion

(2021) Vikram Surendran et al.   Biofabrication

Worm-Based Microfluidic Biosensor for Real-Time Assessment of the Metastatic Status

(2021) Jing Zhang et al.   Cancers

Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis

(2021) Hyeon-Yeol Cho et al.   Frontiers in Bioengineering and Biotechnology

CRISPR-powered electrochemical microfluidic multiplexed biosensor for target amplification-free miRNA diagnostics

(2021) Richard Bruch et al.   BIOSENSORS & BIOELECTRONICS

Towards microfluidic-based exosome isolation and detection for tumor therapy

(2021) Jie Wang et al.   Nano Today

A simple, low cost and reusable microfluidic gradient strategy and its application in modeling cancer invasion

(2021) Mohamadmahdi Samandari et al.   Scientific Reports

Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread

(2021) Carly Strelez et al.   iScience

The driving role of the Cdk5/Tln1/FAKS732 axis in cancer cell extravasation dissected by human vascularized microfluidic models

(2021) Mara Gilardi et al.   BIOMATERIALS

CRISPR-Cas13 System as a Promising and Versatile Tool for Cancer Diagnosis, Therapy, and Research

(2021) Fahreddin Palaz et al.   ACS Synthetic Biology

HER2 Expression in Circulating Tumour Cells Isolated from Metastatic Breast Cancer Patients Using a Size-Based Microfluidic Device

(2021) Cláudia Lopes et al.   Cancers

Microfluidic chip for rapid and selective isolation of tumor-derived extracellular vesicles for early diagnosis and metastatic risk evaluation of breast cancer

(2021) Hogyeong Gwak et al.   BIOSENSORS & BIOELECTRONICS

Breast cancer models: Engineering the tumor microenvironment

(2020) Gokhan Bahcecioglu et al.   Acta Biomaterialia

Capillary-assisted microfluidic biosensing platform captures single cell secretion dynamics in nanoliter compartments

(2020) Amin Hassanzadeh-Barforoushi et al.   BIOSENSORS & BIOELECTRONICS

ctDNA Detection in Microfluidic Platform: A Promising Biomarker for Personalized Cancer Chemotherapy

(2020) Samla Gauri et al.   Journal of Sensors

A novel Wick‐Like Paper‐Based Microfluidic Device for 3D Cell Culture and Anti‐Cancer Drugs Screening

(2020) Shu‐xia Fu et al.   Biotechnology Journal

Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening

(2020) Vincent van Duinen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor-Microenvironment-on-a-Chip for Evaluating Nanoparticle-Loaded Macrophages for Drug Delivery

(2020) Hao-Fei Wang et al.   ACS Biomaterials-Science & Engineering

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

(2020) Junyoung Kim et al.   ACS Nano

Molecular Mechanisms of CRISPR-Cas Immunity in Bacteria

(2020) Philip M. Nussenzweig et al.   Annual Review of Genetics

New Developments in Anti-Angiogenic Therapy of Cancer, Review and Update

(2020) Samaneh Ghasemali et al.   Anti-Cancer Agents in Medicinal Chemistry

The tumor microenvironment

(2020) Nicole M. Anderson et al.   CURRENT BIOLOGY

Characterising a PDMS based 3D cell culturing microfluidic platform for screening chemotherapeutic drug cytotoxic activity

(2020) M. Ibrahim Khot et al.   Scientific Reports

3D Microfluidic Platform and Tumor Vascular Mapping for Evaluating Anti-Angiogenic RNAi-Based Nanomedicine

(2020) Somin Lee et al.   ACS Nano

An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics

(2020) Tian Tian et al.   ACS Nano

Recent advances in microfluidic technology and applications for anti-cancer drug screening

(2020) Yiwei Shi et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

3D Tumor Models and Their Use for the Testing of Immunotherapies

(2020) Nicolas Boucherit et al.   Frontiers in Immunology

Microfluidic biosensing of circulating tumor cells (CTCs): Recent progress and challenges in efficient diagnosis of cancer

(2020) Fatemeh Farshchi et al.   BIOMEDICINE & PHARMACOTHERAPY

Organ-on-a-Chip for Cancer and Immune Organs Modeling

(2019) Wujin Sun et al.   Advanced Healthcare Materials

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro Reconstruction of Brain Tumor Microenvironment

(2019) Ilkyoo Koh et al.   BioChip Journal

High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity

(2019) Yuanyue Shan et al.   ANALYTICAL CHEMISTRY

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

(2019) Danh D Truong et al.   CANCER RESEARCH

Recent advances on application of peptide nucleic acids as a bioreceptor in biosensors development

(2019) Arezoo Saadati et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

(2019) Hamed Tavakoli et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Microfluidics for studying metastatic patterns of lung cancer

(2019) Monika Ruzycka et al.   JOURNAL OF NANOBIOTECHNOLOGY

Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos

(2019) Annalisa Mercurio et al.   Frontiers in Pharmacology

3D Microfluidic Bone Tumor Microenvironment Comprised of Hydroxyapatite/Fibrin Composite

(2019) Jungho Ahn et al.   Frontiers in Bioengineering and Biotechnology

Microfluidic strategies for label-free exosomes isolation and analysis

(2019) Wentao Su et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

CRISPR/Cas13a‐Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification‐Free miRNA Diagnostics

(2019) Richard Bruch et al.   ADVANCED MATERIALS

Microfluidics as an Enabling Technology for Personalized Cancer Therapy

(2019) Lukas Mathur et al.   Small

Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer

(2019) Ya Chang et al.   Applied Materials Today

A lung cancer-on-chip platform with integrated biosensors for physiological monitoring and toxicity assessment

(2019) Muhammad Asad Ullah Khalid et al.   BIOCHEMICAL ENGINEERING JOURNAL

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

(2018) Masatoshi Maeki et al.   ADVANCED DRUG DELIVERY REVIEWS

Review: Microfluidics technologies for blood-based cancer liquid biopsies

(2018) Yuxi Sun et al.   ANALYTICA CHIMICA ACTA

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Molecular targeted therapy: treating cancer with specificity

(2018) Yeuan Ting Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

(2018) Xingyuan Yang et al.   LAB ON A CHIP

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

(2018) Qingfu Zhu et al.   LAB ON A CHIP

Single-Exosome-Counting Immunoassays for Cancer Diagnostics

(2018) Chunchen Liu et al.   NANO LETTERS

Label-free detection of live cancer cells and DNA hybridization using 3D multilayered plasmonic biosensor

(2018) Shuyan Zhu et al.   NANOTECHNOLOGY

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

Enumeration of circulating tumor cells and investigation of cellular responses using aptamer-immobilized AlGaN/GaN high electron mobility transistor sensor array

(2018) Anil Kumar Pulikkathodi et al.   SENSORS AND ACTUATORS B-CHEMICAL

Combining Multiplex SERS Nanovectors and Multivariate Analysis for In Situ Profiling of Circulating Tumor Cell Phenotype Using a Microfluidic Chip

(2018) Yizhi Zhang et al.   Small

A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells

(2018) Sijie Hao et al.   Small

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

(2018) Sharon Wei Ling Lee et al.   Frontiers in Immunology

A review of microfluidic approaches for investigating cancer extravasation during metastasis

(2018) Yu-Heng Vivian Ma et al.   Microsystems & Nanoengineering

A micro-/nano-chip and quantum dots-based 3D cytosensor for quantitative analysis of circulating tumor cells

(2018) Xuan Wu et al.   JOURNAL OF NANOBIOTECHNOLOGY

From Lab on a Chip to Point of Care Devices: The Role of Open Source Microcontrollers

(2018) Trieu Nguyen et al.   Micromachines

Simple and Low-Cost Sampling of Cell-Free Nucleic Acids from Blood Plasma for Rapid and Sensitive Detection of Circulating Tumor DNA

(2018) Choong Eun Jin et al.   Advanced Science

Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma

(2018) Fang Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

From chip-in-a-lab to lab-on-a-chip: a portable Coulter counter using a modular platform

(2018) Stefan Dekker et al.   Microsystems & Nanoengineering

High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing

(2017) Yinghui Guan et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Circulating cell-free nucleic acids and platelets as a liquid biopsy in the provision of personalized therapy for lung cancer patients

(2017) L. Sorber et al.   LUNG CANCER

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

(2017) Michelle B Chen et al.   Nature Protocols

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

(2017) Mengxi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

(2017) Altug Ozcelikkale et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Microfluidic hydrodynamic focusing synthesis of polymer-lipid nanoparticles for siRNA delivery

(2017) Xueqin Huang et al.   Oncotarget

Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro

(2017) Ken-ichiro Kamei et al.   RSC Advances

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Exosomes: Origins and Therapeutic Potential for Neurodegenerative Disease

(2017) Diana K. Sarko et al.   Frontiers in Neuroscience

Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences

(2017) Daniel T. Chiu et al.   Chem

A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche

(2017) Hacer Ezgi Karakas et al.   Scientific Reports

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Microfluidic models for adoptive cell-mediated cancer immunotherapies

(2016) Giulia Adriani et al.   DRUG DISCOVERY TODAY

Multiplexing slanted spiral microchannels for ultra-fast blood plasma separation

(2016) Mehdi Rafeie et al.   LAB ON A CHIP

A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

(2016) Zheng Zhao et al.   LAB ON A CHIP

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

(2016) R. Portillo-Lara et al.   LAB ON A CHIP

The cancer's gone, but did chemotherapy damage your heart?

(2016) Milena Bellin et al.   Nature Reviews Cardiology

Affinity Versus Label-Free Isolation of Circulating Tumor Cells: Who Wins?

(2016) Vasudha Murlidhar et al.   Small

Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model

(2016) Lilu Liu et al.   RSC Advances

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Engineering a 3D microfluidic culture platform for tumor-treating field application

(2016) Andrea Pavesi et al.   Scientific Reports

Acoustic Purification of Extracellular Microvesicles

(2015) Kyungheon Lee et al.   ACS Nano

Microfluidic Multiculture Assay to Analyze Biomolecular Signaling in Angiogenesis

(2015) Ashleigh B. Theberge et al.   ANALYTICAL CHEMISTRY

Monitoring of TGF-β 1-Induced Human Lung Adenocarcinoma A549 Cells Epithelial-Mesenchymal Transformation Process by Measuring Cell Adhesion Force with a Microfluidic Device

(2015) Yuan Li et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Evaluation of photodynamic therapy efficiency using an in vitro three-dimensional microfluidic breast cancer tissue model

(2015) Yamin Yang et al.   LAB ON A CHIP

Lab-on-a-chip devices: How to close and plug the lab?

(2015) Yuksel Temiz et al.   MICROELECTRONIC ENGINEERING

Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells

(2015) Weiyi Qian et al.   Small

Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes

(2014) Shailender Singh Kanwar et al.   LAB ON A CHIP

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Commercialization of microfluidic devices

(2014) Lisa R. Volpatti et al.   TRENDS IN BIOTECHNOLOGY

Highly sensitive enumeration of circulating tumor cells in lung cancer patients using a size-based filtration microfluidic chip

(2013) Ting Huang et al.   BIOSENSORS & BIOELECTRONICS

The past, present and potential for microfluidic reactor technology in chemical synthesis

(2013) Katherine S. Elvira et al.   Nature Chemistry

Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets

(2013) Hyeun Joong Yoon et al.   Nature Nanotechnology

Integration of rapid DNA hybridization and capillary zone electrophoresis using bidirectional isotachophoresis

(2012) Supreet S. Bahga et al.   ANALYST

Clinically Relevant Microfluidic Magnetophoretic Isolation of Rare-Cell Populations for Diagnostic and Therapeutic Monitoring Applications

(2012) Brian D. Plouffe et al.   ANALYTICAL CHEMISTRY

Label-free reflectometric interference microchip biosensor based on nanoporous alumina for detection of circulating tumour cells

(2012) Tushar Kumeria et al.   BIOSENSORS & BIOELECTRONICS

Standards for connecting microfluidic devices?

(2012) Henne van Heeren   LAB ON A CHIP

An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping

(2012) Nien-Tsu Huang et al.   LAB ON A CHIP

Commercialization of microfluidic point-of-care diagnostic devices

(2012) Curtis D. Chin et al.   LAB ON A CHIP

Microfluidic approaches for cancer cell detection, characterization, and separation

(2012) Jian Chen et al.   LAB ON A CHIP

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Point of Care Diagnostics: Status and Future

(2011) Vladimir Gubala et al.   ANALYTICAL CHEMISTRY

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics

(2011) Deniz Pekin et al.   LAB ON A CHIP

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

(2010) Daniel Mark et al.   CHEMICAL SOCIETY REVIEWS

Label-Free Biosensors Based on Aptamer-Modified Graphene Field-Effect Transistors

(2010) Yasuhide Ohno et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microfluidics for cell separation

(2010) Ali Asgar S. Bhagat et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Automated microfluidic protein immunoblotting

(2010) Mei He et al.   Nature Protocols

Electrotaxis of lung cancer cells in a multiple-electric-field chip

(2009) Ching-Wen Huang et al.   BIOSENSORS & BIOELECTRONICS

Hype, hope and hubris: the quest for the killer application in microfluidics

(2009) Holger Becker   LAB ON A CHIP

Chemical Analysis of Single Cells

(2008) Laura M. Borland et al.   Annual Review of Analytical Chemistry

Deformability study of breast cancer cells using microfluidics

(2008) H. W. Hou et al.   BIOMEDICAL MICRODEVICES

Cell-free DNA resuscitated for tumor testing

(2008) Michael Fleischhacker et al.   NATURE MEDICINE