Journal
LAB ON A CHIP
Volume 18, Issue 12, Pages 1690-1703Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8lc00246k
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Funding
- USDA-NIFA [2017-67021-26600]
- NIH NIGMS [P20 GM103418, P20 GM103638]
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Study of extracellular vesicles (EVs), particularly exosomes, holds significant promise; however, it is technically challenging to define these small and molecularly diverse nanovesicles. With intrinsic molecular payload and biodegradability, molecular engineering of exosomes opens new avenues for mediating cellular responses and developing novel nano-delivery systems in precision therapeutics. Microfluidic lab-on-chip technology is playing pivotal roles in this emerging field. In this review, we have examined scientific advancements of microfluidic technology for engineering exosomes and assessed future applications and perspectives in developing precision therapeutics; this can serve the community via identification of potential new research areas or technologies that are urgently needed in precision therapeutics.
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