CRISPR-Cas13 System as a Promising and Versatile Tool for Cancer Diagnosis, Therapy, and Research

High-Fidelity CRISPR/Cas13a trans-Cleavage-Triggered Rolling Circle Amplified DNAzyme for Visual Profiling of MicroRNA

(2021) Ting Zhou et al.   ANALYTICAL CHEMISTRY

A CRISPR/Cas13a-powered catalytic electrochemical biosensor for successive and highly sensitive RNA diagnostics

(2021) Yan Sheng et al.   BIOSENSORS & BIOELECTRONICS

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CRISPR-based tools: Alternative methods for the diagnosis of COVID-19

(2021) Fahreddin Palaz et al.   CLINICAL BIOCHEMISTRY

CRISPR technologies for precise epigenome editing

(2021) Muneaki Nakamura et al.   NATURE CELL BIOLOGY

Cryo-EM structure of the RNA-guided ribonuclease Cas12g

(2021) Zhuang Li et al.   Nature Chemical Biology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Effective downregulation of BCR-ABL tumorigenicity by RNA targeted CRISPR-Cas13a

(2021) Aditya Singh et al.   CURRENT GENE THERAPY

Acetyl‐CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs

(2021) Wenjun Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents

(2021) Emmeline L. Blanchard et al.   NATURE BIOTECHNOLOGY

CRISPR-powered electrochemical microfluidic multiplexed biosensor for target amplification-free miRNA diagnostics

(2021) Richard Bruch et al.   BIOSENSORS & BIOELECTRONICS

Conditional gene silencing via a CRISPR system in cerebellar Purkinje cells

(2021) Qin-Wei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses

(2020) Tuan M. Nguyen et al.   CELL RESEARCH

Cancer gene therapy by NF-κB-activated cancer cell-specific expression of CRISPR/Cas9 targeting telomeres

(2020) Wei Dai et al.   GENE THERAPY

Capturing RNA–protein interaction via CRUIS

(2020) Ziheng Zhang et al.   NUCLEIC ACIDS RESEARCH

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

(2020) Jun Liu et al.   SCIENCE

A CRISPR/Cas13-based approach demonstrates biological relevance of vlinc class of long non-coding RNAs in anticancer drug response

(2020) Dongyang Xu et al.   Scientific Reports

A Multifunction Lipid-Based CRISPR-Cas13a Genetic Circuit Delivery System for Bladder Cancer Gene Therapy

(2020) Jing Fan et al.   ACS Synthetic Biology

CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

(2020) Changyang Zhou et al.   National Science Review

“Sample-to-Answer” Detection of Rare ctDNA Mutation from 2 mL Plasma with a Fully Integrated DNA Extraction and Digital Droplet PCR Microdevice for Liquid Biopsy

(2020) Zhi Geng et al.   ANALYTICAL CHEMISTRY

Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance

(2020) Elaine Kilgour et al.   CANCER CELL

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

(2020) Dan Wang et al.   CELL

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

(2020) Timothy R. Abbott et al.   CELL

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Phase I study of CRISPR-engineered CAR-T cells with PD-1 inactivation in treating mesothelin-positive solid tumors.

(2020) Zhenguang Wang et al.   JOURNAL OF CLINICAL ONCOLOGY

CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells

(2020) Ping Lin et al.   MOLECULAR CELL

Massively multiplexed nucleic acid detection with Cas13

(2020) Cheri M. Ackerman et al.   NATURE

Massively parallel Cas13 screens reveal principles for guide RNA design

(2020) Hans-Hermann Wessels et al.   NATURE BIOTECHNOLOGY

Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer

(2020) You Lu et al.   NATURE MEDICINE

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

(2020) Jiexin Li et al.   NUCLEIC ACIDS RESEARCH

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity

(2020) Alexander J. Meeske et al.   SCIENCE

Reprogrammed CRISPR‑Cas13a targeting the HPV16/18 E6 gene inhibits proliferation and induces apoptosis in E6‑transformed keratinocytes

(2020) Chunjing Li et al.   Experimental and Therapeutic Medicine

N6-methyladenosine regulates glycolysis of cancer cells through PDK4

(2020) Zihan Li et al.   Nature Communications

Nucleic Acid Detection Using CRISPR/Cas Biosensing Technologies

(2020) Rashid Aman et al.   ACS Synthetic Biology

Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing

(2020) Isabel Weisheit et al.   Cell Reports

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

(2020) Bingbing He et al.   Protein & Cell

CRISPR/Cas13a Powered Portable Electrochemiluminescence Chip for Ultrasensitive and Specific MiRNA Detection

(2020) Ting Zhou et al.   Advanced Science

In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs’ cleavage by CRISPR/Cas13a system

(2020) Yili Chen et al.   ANTIVIRAL RESEARCH

The CRISPR-Cas13a system interferes with Purkinje cell dendritic development

(2020) Qin-Wei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos

(2020) Gopal Kushawah et al.   DEVELOPMENTAL CELL

Drugging “undruggable” genes for cancer treatment: Are we making progress?

(2020) Michael J. Duffy et al.   INTERNATIONAL JOURNAL OF CANCER

Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons

(2020) Raffaella Melfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

(2020) Christopher Wilson et al.   NATURE BIOTECHNOLOGY

CRISPR-assisted detection of RNA–protein interactions in living cells

(2020) Wenkai Yi et al.   NATURE METHODS

Photoactivatable RNA N 6 ‐Methyladenosine Editing with CRISPR‐Cas13

(2020) Jie Zhao et al.   Small

CRISPR artificial splicing factors

(2020) Menghan Du et al.   Nature Communications

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

(2020) Kotaro Kiga et al.   Nature Communications

Structure-based design of gRNA for Cas13

(2020) Srinivas Bandaru et al.   Scientific Reports

Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

(2020) Chinmoy Saha et al.   Science Advances

CRISPR/Cas13d-Mediated Microbial RNA Knockdown

(2020) Kun Zhang et al.   Frontiers in Bioengineering and Biotechnology

Programmable RNA Targeting Using CasRx in Flies

(2020) Anna B. Buchman et al.   CRISPR Journal

Molecular Mechanisms of CRISPR-Cas Immunity in Bacteria

(2020) Philip M. Nussenzweig et al.   Annual Review of Genetics

CRISPR-Based Diagnosis of Infectious and Noninfectious Diseases

(2020) Somayeh Jolany vangah et al.   BIOLOGICAL PROCEDURES ONLINE

Programmable C‐to‐U RNA editing using the human APOBEC 3A deaminase

(2020) Xinxin Huang et al.   EMBO JOURNAL

REPAIR x, a specific yet highly efficient programmable A > I RNA base editor

(2020) Yajing Liu et al.   EMBO JOURNAL

SPRINT: a Cas13a-based platform for detection of small molecules

(2020) Roman S Iwasaki et al.   NUCLEIC ACIDS RESEARCH

Collective cancer cell invasion requires RNA accumulation at the invasive front

(2020) George Chrisafis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting

(2020) Shuo Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-Cas13d for Gene Knockdown and Engineering of CHO Cells

(2020) Chih-Che Shen et al.   ACS Synthetic Biology

Targeted RNA Knockdown by a Type III CRISPR-Cas Complex in Zebrafish

(2020) Thomas Fricke et al.   CRISPR Journal

An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics

(2020) Tian Tian et al.   ACS Nano

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

(2020) Parinaz Fozouni et al.   CELL

The role of alternative splicing in cancer: From oncogenesis to drug resistance

(2020) Rocco Sciarrillo et al.   DRUG RESISTANCE UPDATES

Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells

(2020) Saifullah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Screening for functional circular RNAs using the CRISPR–Cas13 system

(2020) Siqi Li et al.   NATURE METHODS

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultrasensitive and high-specific microRNA detection using hyper-branching rolling circle amplified CRISPR/Cas13a biosensor

(2020) Mengqi Huang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Next-Generation CRISPR Technologies and Their Applications in Gene and Cell Therapy

(2020) M. Alejandra Zeballos C. et al.   TRENDS IN BIOTECHNOLOGY

A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1

(2020) Nan Zhang et al.   Frontiers in Genetics

A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy

(2020) Jinliang Gao et al.   Molecular Therapy-Oncolytics

CRISPR-Cas13a Targeting the Enhancer RNA-SMAD7e Inhibits Bladder Cancer Development Both in vitro and in vivo

(2020) Wenan Che et al.   Frontiers in Molecular Biosciences

Silencing of lncRNA MIR497HG via CRISPR/Cas13d Induces Bladder Cancer Progression Through Promoting the Crosstalk Between Hippo/Yap and TGF-β/Smad Signaling

(2020) Changshui Zhuang et al.   Frontiers in Molecular Biosciences

Ultrasensitive electrochemical assay for microRNA-21 based on CRISPR/Cas13a-assisted catalytic hairpin assembly

(2020) Ying Cui et al.   TALANTA

Versatile detection with CRISPR/Cas system from applications to challenges

(2020) Hui Wu et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

CRISPR–Cas: a tool for cancer research and therapeutics

(2019) Hao Yin et al.   Nature Reviews Clinical Oncology

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

(2019) Ian M. Slaymaker et al.   Cell Reports

Liquid biopsy and minimal residual disease — latest advances and implications for cure

(2019) Klaus Pantel et al.   Nature Reviews Clinical Oncology

Identification of preexisting adaptive immunity to Cas9 proteins in humans

(2019) Carsten T. Charlesworth et al.   NATURE MEDICINE

High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity

(2019) Yuanyue Shan et al.   ANALYTICAL CHEMISTRY

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

(2019) Zhipeng Ma et al.   NATURE

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

(2019) Dominic G. Rothwell et al.   NATURE MEDICINE

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

(2019) Jason K. Sicklick et al.   NATURE MEDICINE

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A cytosine deaminase for programmable single-base RNA editing

(2019) Omar O. Abudayyeh et al.   SCIENCE

Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d

(2019) Bo Zhang et al.   Nature Communications

Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy

(2019) Ana M. Moreno et al.   Nature Biomedical Engineering

SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes

(2019) Xiao Song et al.   CANCER RESEARCH

Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus

(2019) Run-Wen Yao et al.   MOLECULAR CELL

SHERLOCK: nucleic acid detection with CRISPR nucleases

(2019) Max J. Kellner et al.   Nature Protocols

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

(2019) Lei Xu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tissue-restricted Genome Editing in vivo Specified by MicroRNA-repressible Anti-CRISPR Proteins

(2019) Jooyoung Lee et al.   RNA

CRISPR-mediated live imaging of genome editing and transcription

(2019) Haifeng Wang et al.   SCIENCE

The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells

(2019) Qixue Wang et al.   Advanced Science

Dual‐Locking Nanoparticles Disrupt the PD‐1/PD‐L1 Pathway for Efficient Cancer Immunotherapy

(2019) Zhanzhan Zhang et al.   ADVANCED MATERIALS

CRISPR/Cas13a‐Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification‐Free miRNA Diagnostics

(2019) Richard Bruch et al.   ADVANCED MATERIALS

Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity

(2019) Guangchuan Wang et al.   NATURE IMMUNOLOGY

Advancing CRISPR-Based Programmable Platforms beyond Genome Editing in Mammalian Cells

(2019) Yasutomi Higashikuni et al.   ACS Synthetic Biology

CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection

(2019) Qian Chen et al.   ANALYTICAL CHEMISTRY

Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems

(2019) Liang-Zhong Yang et al.   MOLECULAR CELL

Programmable Inhibition and Detection of RNA Viruses Using Cas13

(2019) Catherine A. Freije et al.   MOLECULAR CELL

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Strategies for the CRISPR-Based Therapeutics

(2019) Bin Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Composition and Diversity of CRISPR-Cas13a Systems in the Genus Leptotrichia

(2019) Shinya Watanabe et al.   Frontiers in Microbiology

A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment

(2018) Xiao Zhao et al.   CANCER LETTERS

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

(2018) Silvana Konermann et al.   CELL

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

The challenge of drug resistance in cancer treatment: a current overview

(2018) Michail Nikolaou et al.   CLINICAL & EXPERIMENTAL METASTASIS

Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis

(2018) Amogha Tadimety et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Molecular targeted therapy: treating cancer with specificity

(2018) Yeuan Ting Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Control the intracellular NF-κB activity by a sensor consisting of miRNA and decoy

(2018) Danyang Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Multiple functions of m6A RNA methylation in cancer

(2018) Yutian Pan et al.   Journal of Hematology & Oncology

Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems

(2018) Mitchell R. O'Connell   JOURNAL OF MOLECULAR BIOLOGY

Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein

(2018) Winston X. Yan et al.   MOLECULAR CELL

CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9

(2018) Gaurav Dugar et al.   MOLECULAR CELL

Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis

(2018) Beth A. Rousseau et al.   MOLECULAR CELL

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

CRISPR off-target analysis in genetically engineered rats and mice

(2018) Keith R. Anderson et al.   NATURE METHODS

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis

(2018) Lovorka Stojic et al.   NUCLEIC ACIDS RESEARCH

Implementation of the CRISPR-Cas13a system in fission yeast and its repurposing for precise RNA editing

(2018) Xinyun Jing et al.   NUCLEIC ACIDS RESEARCH

Field-deployable viral diagnostics using CRISPR-Cas13

(2018) Cameron Myhrvold et al.   SCIENCE

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

Significance of Liquid Biopsy for Monitoring and Therapy Decision of Colorectal Cancer

(2018) Susanne Klein-Scory et al.   Translational Oncology

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma

(2018) Masakazu Yoshida et al.   Oncotarget

RNA-dependent RNA targeting by CRISPR-Cas9

(2018) Steven C Strutt et al.   eLife

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

(2018) Cheng Zhang et al.   CELL

A new cancer immunotherapy based on a cancer cell-specific NF-κB-activating gene expression technique

(2018) Danyang Wang et al.   HUMAN GENE THERAPY

Enhancer RNA - P2RY2e induced by estrogen promotes malignant behaviors of bladder cancer

(2018) Mengting Ding et al.   International Journal of Biological Sciences

Oestrogen promotes tumorigenesis of bladder cancer by inducing the enhancer RNA-eGREB1

(2018) Mengting Ding et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A phase I trial of PD-1 deficient engineered T cells with CRISPR/Cas9 in patients with advanced non-small cell lung cancer.

(2018) You Lu et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and activity of programmed cell death-1 gene knockout engineered t cells in patients with previously treated advanced esophageal squamous cell carcinoma: An open-label, single-arm phase I study.

(2018) Zhao Jing et al.   JOURNAL OF CLINICAL ONCOLOGY

RNA Guide Complementarity Prevents Self-Targeting in Type VI CRISPR Systems

(2018) Alexander J. Meeske et al.   MOLECULAR CELL

Cas9 immunity creates challenges for CRISPR gene editing therapies

(2018) Julie M. Crudele et al.   Nature Communications

Circulating miRNA panels for specific and early detection in bladder cancer

(2018) Wataru Usuba et al.   CANCER SCIENCE

Structural insights into Cas13b-guided CRISPR RNA maturation and recognition

(2018) Bo Zhang et al.   CELL RESEARCH

Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9

(2018) Felix Bubeck et al.   NATURE METHODS

Functionally diverse type V CRISPR-Cas systems

(2018) Winston X. Yan et al.   SCIENCE

Novel splice-switching oligonucleotide promotesBRCA1aberrant splicing and susceptibility to PARP inhibitor action

(2017) Lindsay D. Smith et al.   INTERNATIONAL JOURNAL OF CANCER

Exosomal proteins as potential markers of tumor diagnosis

(2017) Aichun Li et al.   Journal of Hematology & Oncology

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

(2017) Jose C. Contreras-Naranjo et al.   LAB ON A CHIP

Role of exosomal proteins in cancer diagnosis

(2017) Weihua Li et al.   Molecular Cancer

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

(2017) Aaron A. Smargon et al.   MOLECULAR CELL

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes

(2017) Alexandra East-Seletsky et al.   MOLECULAR CELL

RNA targeting with CRISPR–Cas13

(2017) Omar O. Abudayyeh et al.   NATURE

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Diversity and evolution of class 2 CRISPR–Cas systems

(2017) Sergey Shmakov et al.   NATURE REVIEWS MICROBIOLOGY

Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme

(2017) Gavin J Knott et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme

(2017) Gavin J Knott et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides

(2017) Jun Liu et al.   Oncotarget

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Leptotrichia species in human infections II

(2017) Emenike R. K. Eribe et al.   Journal of Oral Microbiology

Self-powered integrated microfluidic point-of-care low-cost enabling (SIMPLE) chip

(2017) Erh-Chia Yeh et al.   Science Advances

RNA-targeted therapeutics in cancer clinical trials: Current status and future directions

(2016) Pedro Barata et al.   CANCER TREATMENT REVIEWS

ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma

(2016) Yuan-Bin Chen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Synthetic Bax-Anti Bcl2 combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer

(2016) Li Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

The cancer's gone, but did chemotherapy damage your heart?

(2016) Milena Bellin et al.   Nature Reviews Cardiology

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

(2016) S. John Liu et al.   SCIENCE

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Linking Long Noncoding RNA Localization and Function

(2016) Ling-Ling Chen   TRENDS IN BIOCHEMICAL SCIENCES

The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

(2016) Kiranmai Gumireddy et al.   Nature Communications

Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma

(2016) Nicole R. Parker et al.   Scientific Reports

Targeting cellular mRNAs translation by CRISPR-Cas9

(2016) Yuchen Liu et al.   Scientific Reports

Sample-to-Answer Isolation and mRNA Profiling of Circulating Tumor Cells

(2015) Reza M. Mohamadi et al.   ANALYTICAL CHEMISTRY

A circulating miRNA signature as a diagnostic biomarker for non-invasive early detection of breast cancer

(2015) Lei Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

(2015) Sergey Shmakov et al.   MOLECULAR CELL

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

(2015) Giulia Siravegna et al.   NATURE MEDICINE

The influence of subclonal resistance mutations on targeted cancer therapy

(2015) Michael W. Schmitt et al.   Nature Reviews Clinical Oncology

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

(2015) Sebastien A. Burel et al.   NUCLEIC ACIDS RESEARCH

Pro-apoptotic effects of splice-switching oligonucleotides targeting Bcl-x pre-mRNA in human glioma cell lines

(2015) ZHAOHUI LI et al.   ONCOLOGY REPORTS

Cas9-mediated targeting of viral RNA in eukaryotic cells

(2015) Aryn A. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fully Automated Sample Preparation Microsystem for Genetic Testing of Hereditary Hearing Loss Using Two-Color Multiplex Allele-Specific PCR

(2014) Bin Zhuang et al.   ANALYTICAL CHEMISTRY

Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms

(2014) Sariah Liu et al.   CANCER TREATMENT REVIEWS

Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies

(2014) Yan Deng et al.   GENE

Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity

(2014) Bindhu Madhavan et al.   INTERNATIONAL JOURNAL OF CANCER

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

RNA editing inRHOQpromotes invasion potential in colorectal cancer

(2014) Sae-Won Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programmable RNA recognition and cleavage by CRISPR/Cas9

(2014) Mitchell R. O’Connell et al.   NATURE

CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus

(2014) Ziga Zebec et al.   NUCLEIC ACIDS RESEARCH

Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo

(2013) T O Nielsen et al.   BRITISH JOURNAL OF CANCER

Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients

(2013) V. Taly et al.   CLINICAL CHEMISTRY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer

(2011) R. Liu et al.   CLINICAL CHEMISTRY

A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer

(2011) Fabrizio Bianchi et al.   EMBO Molecular Medicine

Toxicity as a Biomarker of Efficacy of Molecular Targeted Therapies: Focus on EGFR and VEGF Inhibiting Anticancer Drugs

(2011) R. Dienstmann et al.   ONCOLOGIST

Antitumorigenic potential of STAT3 alternative splicing modulation

(2011) F. Zammarchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)

(2010) Ivan K. Dimov et al.   LAB ON A CHIP