Where the Action Is—Leukocyte Recruitment in Atherosclerosis

Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis

(2021) Anastasia V. Poznyak et al.   Frontiers in Pharmacology

Inflammatory Chemokines in Atherosclerosis

(2021) Selin Gencer et al.   Cells

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

(2021) Fabiana Baganha et al.   ANGIOGENESIS

Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease

(2021) Carina Mauersberger et al.   Cells

Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues

(2021) Laleh Pezhman et al.   Frontiers in Cell and Developmental Biology

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability

(2021) Marios K. Georgakis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials

(2021) Aernoud T L Fiolet et al.   EUROPEAN HEART JOURNAL

Proteomics: A Tool to Study Platelet Function

(2021) Olga Shevchuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis

(2021) Thijs J. Sluiter et al.   Biomedicines

Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation

(2021) Julia Hinterdobler et al.   ANTIOXIDANTS & REDOX SIGNALING

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

(2021) Frank L J Visseren et al.   EUROPEAN HEART JOURNAL

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis

(2021) Julia Hinterdobler et al.   EUROPEAN HEART JOURNAL

Genetics of coronary artery disease in the post‐GWAS era

(2021) Zhifen Chen et al.   JOURNAL OF INTERNAL MEDICINE

Vascular Endothelial Galectins in Leukocyte Trafficking

(2021) Abbey Lightfoot et al.   Frontiers in Immunology

Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside

(2021) Alexandre Mezentsev et al.   Biomedicines

Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease

(2021) Gaukhar Baidildinova et al.   Frontiers in Cardiovascular Medicine

Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies

(2021) Thorsten Kessler et al.   JACC-Basic to Translational Science

Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis

(2021) Jan Hettwer et al.   CARDIOVASCULAR RESEARCH

Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity

(2021) Sarah E. Basehore et al.   CIRCULATION RESEARCH

Association of chemokines IP-10/CXCL10 and I-TAC/CXCL11 with insulin resistance and enhance leukocyte endothelial arrest in obesity

(2021) Beatriz Moreno et al.   MICROVASCULAR RESEARCH

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

(2020) Jan Borén et al.   EUROPEAN HEART JOURNAL

β2 Integrins—Multi-Functional Leukocyte Receptors in Health and Disease

(2020) Monika Bednarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils as regulators of cardiovascular inflammation

(2020) Carlos Silvestre-Roig et al.   Nature Reviews Cardiology

Soluble LOX‐1: A Novel Biomarker in Patients With Coronary Artery Disease, Stroke, and Acute Aortic Dissection?

(2020) Anja Hofmann et al.   Journal of the American Heart Association

CD31 as a Therapeutic Target in Atherosclerosis

(2020) Giuseppina Caligiuri   CIRCULATION RESEARCH

Understanding the mechanisms that facilitate specificity, not redundancy, of chemokine‐mediated leukocyte recruitment

(2020) Douglas P. Dyer   IMMUNOLOGY

T cell subsets and functions in atherosclerosis

(2020) Ryosuke Saigusa et al.   Nature Reviews Cardiology

SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease

(2020) So Ra Kim et al.   Nature Communications

Association of Circulating microRNAs with Coronary Artery Disease and Usefulness for Reclassification of Healthy Individuals: The REGICOR Study

(2020) Irene R. Dégano et al.   Journal of Clinical Medicine

CD147 is a Novel Interaction Partner of Integrin αMβ2 Mediating Leukocyte and Platelet Adhesion

(2020) David Heinzmann et al.   Biomolecules

Vascular Endothelial Cells and Innate Immunity

(2020) Ying Shao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage polarisation associated with atherosclerosis differentially affects their capacity to handle lipids

(2020) Kajus Baidžajevas et al.   ATHEROSCLEROSIS

Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling

(2020) Lai Wen et al.   BLOOD

Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells

(2020) J Amersfoort et al.   CARDIOVASCULAR RESEARCH

Pathogenic Autoimmunity in Atherosclerosis Evolves from Initially Protective ApoB-Reactive CD4 + T-Regulatory Cells

(2020) Dennis Wolf et al.   CIRCULATION

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

(2020) Alma Zernecke et al.   CIRCULATION RESEARCH

Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes

(2020) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

cGMP Signaling in Cardiovascular Diseases

(2020) Tan An Dang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Role of the adaptive immune system in atherosclerosis

(2020) Klaus Ley   BIOCHEMICAL SOCIETY TRANSACTIONS

LDL receptors, caveolae and cholesterol in endothelial dysfunction: oxLDLs accomplices or victims?

(2020) Francesca Luchetti et al.   BRITISH JOURNAL OF PHARMACOLOGY

The molecular mechanism of mechanotransduction in vascular homeostasis and disease

(2020) Yoshito Yamashiro et al.   CLINICAL SCIENCE

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

(2020) Jesse W. Williams et al.   NATURE IMMUNOLOGY

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

(2020) Milton Packer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Colchicine in Patients with Chronic Coronary Disease

(2020) Stefan M. Nidorf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives

(2020) Lei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Monocyte Recruitment, Specification, and Function in Atherosclerosis

(2020) Ki-Wook Kim et al.   Cells

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Maraviroc intensification modulates atherosclerotic progression in HIV suppressed patients at high cardiovascular risk. A randomized, cross-over, pilot study

(2019) Daniela Francisci et al.   Open Forum Infectious Diseases

Chemokine Receptor Redundancy and Specificity Are Context Dependent

(2019) Douglas P. Dyer et al.   IMMUNITY

CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease

(2019) Yvonne Döring et al.   CIRCULATION

Identification of atheroprone shear stress responsive regulatory elements in endothelial cells

(2019) Olga Bondareva et al.   CARDIOVASCULAR RESEARCH

Neutrophil transendothelial migration: updates and new perspectives

(2019) Marie-Dominique Filippi   BLOOD

Circulating monocyte-platelet aggregates are a robust marker of platelet activity in cardiovascular disease

(2019) Nicole Allen et al.   ATHEROSCLEROSIS

Chemokines as Therapeutic Targets in Cardiovascular Disease

(2019) Heidi Noels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis

(2019) Anna Babinska et al.   ATHEROSCLEROSIS

The aorta can act as a site of naïve CD4+ T-cell priming

(2019) Neil MacRitchie et al.   CARDIOVASCULAR RESEARCH

VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism

(2019) Vanessa V. Juettner et al.   JOURNAL OF CELL BIOLOGY

A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation

(2019) Zhishuai Ye et al.   MEDIATORS OF INFLAMMATION

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

(2019) Linzhang Huang et al.   NATURE

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

(2019) Patricia Marchio et al.   Oxidative Medicine and Cellular Longevity

Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans

(2019) Gerard J. Graham et al.   TRENDS IN IMMUNOLOGY

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

(2019) Aleksandar Ivetic et al.   Frontiers in Immunology

Human Neutrophils Will Crawl Upstream on ICAM-1 If Mac-1 Is Blocked

(2019) Alexander Buffone et al.   BIOPHYSICAL JOURNAL

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

(2019) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway

(2019) Jia-Hui Gao et al.   JOURNAL OF LIPID RESEARCH

Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis

(2019) Tessa J. Barrett et al.   Science Translational Medicine

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis

(2018) Carla Winter et al.   Cell Metabolism

Regulatory CD4+T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B

(2018) Takayuki Kimura et al.   CIRCULATION

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

(2018) Maija Ruuth et al.   EUROPEAN HEART JOURNAL

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

The role of monocytosis and neutrophilia in atherosclerosis

(2018) Dimitry A. Chistiakov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective

(2018) Mia Krolikoski et al.   MATRIX BIOLOGY

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

(2018) Zoltan Ungvari et al.   Nature Reviews Cardiology

Atorvastatin enhances endothelial adherens junctions through promoting VE-PTP gene transcription and reducing VE-cadherin-Y731 phosphorylation

(2018) Zihe Huo et al.   VASCULAR PHARMACOLOGY

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

(2018) Dennis Wolf et al.   Nature Communications

LFA-1 in T Cell Migration and Differentiation

(2018) Brandon L. Walling et al.   Frontiers in Immunology

Endothelial Cell Focal Adhesion Regulates Transendothelial Migration and Subendothelial Crawling of T Cells

(2018) Jaehyun Lee et al.   Frontiers in Immunology

S100A8/A9 in Inflammation

(2018) Siwen Wang et al.   Frontiers in Immunology

Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry

(2018) Anouk A.J. Hamers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses

(2018) Janine van Duijn et al.   CARDIOVASCULAR RESEARCH

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

(2018) Tom T P Seijkens et al.   EUROPEAN HEART JOURNAL

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

(2018) Jonathan D. Proto et al.   IMMUNITY

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

(2018) Tamara Girbl et al.   IMMUNITY

TNF-α-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells

(2018) Hyun-Jung Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

(2018) Lai Wen et al.   Nature Communications

Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation

(2018) Jan Rossaint et al.   Frontiers in Immunology

More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking

(2018) Daniel A. Patten et al.   Frontiers in Immunology

Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta

(2018) Sanne L. Maas et al.   Frontiers in Immunology

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

(2017) Sophie J. Bernelot Moens et al.   EUROPEAN HEART JOURNAL

Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice

(2017) Zhen Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation

(2017) Beatrice R. Gittens et al.   JOURNAL OF IMMUNOLOGY

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

(2017) Derek Klarin et al.   NATURE GENETICS

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Effects of dyslipidaemia on monocyte production and function in cardiovascular disease

(2017) Mohammed Shamim Rahman et al.   Nature Reviews Cardiology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Platelets modulate endothelial cell response to dynamic shear stress through PECAM-1

(2017) Daphne Meza et al.   THROMBOSIS RESEARCH

CXCR2 Inhibition – a novel approach to treating CoronAry heart DiseAse (CICADA): study protocol for a randomised controlled trial

(2017) Jubin P. Joseph et al.   Trials

Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure

(2017) Niek Verweij et al.   Scientific Reports

Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments

(2017) Sagi Barzilai et al.   Cell Reports

Antigen Presentation by Vascular Cells

(2017) Jordan S. Pober et al.   Frontiers in Immunology

Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation

(2017) Adelina Curaj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Platelet-derived chemokines in inflammation and atherosclerosis

(2017) Constantinos Bakogiannis et al.   CYTOKINE

Expansion of CD8+ T cells lacking the IL-6 receptor α chain in patients with coronary artery diseases (CAD)

(2016) Yuri Hwang et al.   ATHEROSCLEROSIS

CXCL12 regulates platelet activation via the regulator of G-protein signaling 16

(2016) Zubair A. Karim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling

(2016) Suowen Xu et al.   CELLULAR SIGNALLING

Cathepsin G Controls Arterial But Not Venular Myeloid Cell RecruitmentClinical Perspective

(2016) Almudena Ortega-Gomez et al.   CIRCULATION

CCR5+T-bet+FoxP3+Effector CD4 T Cells Drive AtherosclerosisNovelty and Significance

(2016) Jie Li et al.   CIRCULATION RESEARCH

Human plasma platelet-derived exosomes: effects of aspirin

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Platelet surface expression of SDF-1 is associated with clinical outcomes in the patients with cardiovascular disease

(2016) Dominik Rath et al.   PLATELETS

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

(2016) Hendrik B. Sager et al.   Science Translational Medicine

Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis

(2016) Zhichao Fan et al.   Nature Communications

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

(2016) Niels Heemskerk et al.   Nature Communications

Spatiotemporal Expression Dynamics of Selectins Govern the Sequential Extravasation of Neutrophils and Monocytes in the Acute Inflammatory ResponseSignificance

(2015) Gabriele Zuchtriegel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chemokines Control Mobilization, Recruitment, and Fate of Monocytes in Atherosclerosis

(2015) M. Drechsler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1

(2015) J. Record et al.   BLOOD

Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade

(2015) S. Magwenzi et al.   BLOOD

Monocyte trafficking across the vessel wall

(2015) Teresa Gerhardt et al.   CARDIOVASCULAR RESEARCH

SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4

(2015) Tony G. Walsh et al.   CELLULAR SIGNALLING

Danger Signaling in Atherosclerosis

(2015) S. Zimmer et al.   CIRCULATION RESEARCH

CD8+T Cells Regulate Monopoiesis and Circulating Ly6ChighMonocyte Levels in Atherosclerosis in MiceNovelty and Significance

(2015) Clément Cochain et al.   CIRCULATION RESEARCH

Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function

(2015) S. Lakshmikanthan et al.   EMBO REPORTS

Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors

(2015) Desheng Hu et al.   IMMUNITY

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

(2015) Bartomeu Colom et al.   IMMUNITY

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

(2015) Brian G. Coon et al.   JOURNAL OF CELL BIOLOGY

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Genome-Wide Significant Loci: How Important Are They?

(2015) Johan L.M. Björkegren et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation

(2015) Michael Schnoor et al.   MEDIATORS OF INFLAMMATION

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

(2015) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells

(2015) Kuang-Hsing Chiang et al.   PLoS One

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

(2015) Jean-Eric Alard et al.   Science Translational Medicine

Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4–CXCR7

(2015) M Chatterjee et al.   Cell Death & Disease

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

(2015) Monika Pruenster et al.   Nature Communications

T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors

(2015) Loïc Dupré et al.   Frontiers in Immunology

Experimental research Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice

(2014) Simon Pingel et al.   Archives of Medical Science

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution

(2014) Martin M.N. Schmitt et al.   ATHEROSCLEROSIS

Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies

(2014) Marion Leick et al.   CELL AND TISSUE RESEARCH

FLow-Induced PRotrusions (FLIPRs)

(2014) Claudia Tersteeg et al.   CIRCULATION RESEARCH

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7+S100A8+in vitro and in vivo

(2014) Christian Erbel et al.   Innate Immunity

Antigen Presentation by Human Microvascular Endothelial Cells Triggers ICAM-1-Dependent Transendothelial Protrusion by, and Fractalkine-Dependent Transendothelial Migration of, Effector Memory CD4+ T Cells

(2014) T. D. Manes et al.   JOURNAL OF IMMUNOLOGY

CD43 Plays Both Antiadhesive and Proadhesive Roles in Neutrophil Rolling in a Context-Dependent Manner

(2014) M. Matsumoto et al.   JOURNAL OF IMMUNOLOGY

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Chronic variable stress activates hematopoietic stem cells

(2014) Timo Heidt et al.   NATURE MEDICINE

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

L-selectin deficiency decreases aortic B1a and Breg subsets and promotes atherosclerosis

(2014) Breanne Gjurich et al.   THROMBOSIS AND HAEMOSTASIS

Rho-GTPase signaling in leukocyte extravasation

(2014) Niels Heemskerk et al.   Cell Adhesion & Migration

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment

(2013) Matthew Harrison et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell Sensing of Flow Direction

(2013) Chong Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leukocyte-Specific CCL3 Deficiency Inhibits Atherosclerotic Lesion Development by Affecting Neutrophil Accumulation

(2013) Saskia C.A. de Jager et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin

(2013) M. Vockel et al.   BLOOD

Efficacy of the CCR5 Antagonist Maraviroc in Reducing Early, Ritonavir-Induced Atherogenesis and Advanced Plaque Progression in Mice

(2013) Sabrina Cipriani et al.   CIRCULATION

Cytotoxic and Proinflammatory CD8 + T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice

(2013) Tin Kyaw et al.   CIRCULATION

Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis

(2013) Martin M.N. Schmitt et al.   CIRCULATION

High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice

(2013) Raphael Chèvre et al.   CIRCULATION RESEARCH

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

(2013) Oliver Soehnlein et al.   EMBO Molecular Medicine

Induction of C-X-C Chemokine Receptor Type 7 (CXCR7) Switches Stromal Cell-derived Factor-1 (SDF-1) Signaling and Phagocytic Activity in Macrophages Linked to Atherosclerosis

(2013) Wanshu Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo

(2013) K. Halai et al.   JOURNAL OF CELL SCIENCE

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

(2013) Roland Klingenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

The Complexity of Arterial Classical Monocyte Recruitment

(2013) Maik Drechsler et al.   Journal of Innate Immunity

Increased proatherogenic monocyte-platelet cross-talk in monocyte subpopulations of patients with stable coronary artery disease

(2013) F. S. Czepluch et al.   JOURNAL OF INTERNAL MEDICINE

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions

(2013) Veronica Azcutia et al.   MOLECULAR BIOLOGY OF THE CELL

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis

(2013) Andrew J Murphy et al.   NATURE MEDICINE

The Guanine-Nucleotide Exchange Factor SGEF Plays a Crucial Role in the Formation of Atherosclerosis

(2013) Thomas Samson et al.   PLoS One

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

(2013) Rafaela da Silva et al.   THROMBOSIS AND HAEMOSTASIS

Getting Leukocytes to the Site of Inflammation

(2013) W. A. Muller   VETERINARY PATHOLOGY

Persistent accumulation of interferon-γ-producing CD8+CD56+ T cells in blood from patients with coronary artery disease

(2012) Ida Bergström et al.   ATHEROSCLEROSIS

Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice

(2012) Jong-Gil Park et al.   ATHEROSCLEROSIS

JAM-A protects from thrombosis by suppressing integrin  IIb 3-dependent outside-in signaling in platelets

(2012) M. U. Naik et al.   BLOOD

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

(2012) Yvonne Döring et al.   CIRCULATION RESEARCH

Multiple Roles for Neutrophils in Atherosclerosis

(2012) Oliver Soehnlein   CIRCULATION RESEARCH

Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway

(2012) Caitlin Collins et al.   CURRENT BIOLOGY

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Treatment with Evasin-3 Reduces Atherosclerotic Vulnerability for Ischemic Stroke, but Not Brain Injury in Mice

(2012) Jean-Christophe Copin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

‘Slings’ enable neutrophil rolling at high shear

(2012) Prithu Sundd et al.   NATURE

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

Neutrophil arrest by LFA-1 activation

(2012) Craig T. Lefort et al.   Frontiers in Immunology

Physiological Contribution of CD44 as a Ligand for E-Selectin during Inflammatory T-Cell Recruitment

(2011) Maria Nácher et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of Leukocyte Transendothelial Migration

(2011) William A. Muller   Annual Review of Pathology-Mechanisms of Disease

Recent Advances on the Role of Cytokines in Atherosclerosis

(2011) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Intravital Microscopy on Atherosclerosis in Apolipoprotein E–Deficient Mice Establishes Microvessels as Major Entry Pathways for Leukocytes to Advanced Lesions

(2011) Einar E. Eriksson   CIRCULATION

Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis—But Does Not Affect Immunity and Thrombosis in Mice

(2011) Dennis Wolf et al.   CIRCULATION RESEARCH

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

(2011) S Brili et al.   HEART

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots

(2011) Ziv Shulman et al.   NATURE IMMUNOLOGY

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

Deletion of L-Selectin Increases Atherosclerosis Development in ApoE−/− Mice

(2011) Izabela Rozenberg et al.   PLoS One

Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation

(2011) Luigina Guasti et al.   THROMBOSIS AND HAEMOSTASIS

Neutrophils cascading their way to inflammation

(2011) Christian D. Sadik et al.   TRENDS IN IMMUNOLOGY

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo

(2010) B. Petri et al.   BLOOD

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation

(2010) Ryan E. Feaver et al.   CIRCULATION RESEARCH

LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ

(2010) R. Sumagin et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Influence of Direct Thrombin Inhibitors on the Formation of Platelet-leukocyte Aggregates and Tissue Factor Expression

(2010) Christina Christersson et al.   THROMBOSIS RESEARCH

LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells

(2009) Mark D. Mattaliano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis

(2009) Filip K. Swirski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice

(2009) Duo-Jiao Wu et al.   ATHEROSCLEROSIS

Vaccination against Foxp3+ regulatory T cells aggravates atherosclerosis

(2009) T. van Es et al.   ATHEROSCLEROSIS

Mechanisms underlying neutrophil-mediated monocyte recruitment

(2009) O. Soehnlein et al.   BLOOD

β2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice

(2009) Aksam Merched et al.   CARDIOVASCULAR RESEARCH

CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages

(2009) Christian A. Gleissner et al.   CIRCULATION RESEARCH

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Lymphocyte Crawling and Transendothelial Migration Require Chemokine Triggering of High-Affinity LFA-1 Integrin

(2009) Ziv Shulman et al.   IMMUNITY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis

(2009) Javier Mestas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

P-selectin Glycoprotein Ligand-1 Plays a Crucial Role in the Selective Recruitment of Leukocytes Into the Atherosclerotic Arterial Wall

(2009) Yuqing Huo et al.   TRENDS IN CARDIOVASCULAR MEDICINE

A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

(2008) Vincent Braunersreuther et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice

(2008) Reema Goel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice

(2008) Brian L. Harry et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

(2008) L. Landsman et al.   BLOOD

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice

(2008) E. J.A. van Wanrooij et al.   CARDIOVASCULAR RESEARCH

P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C hi Monocytes and a Major Determinant for Ly-6C hi Monocyte Recruitment to Sites of Atherosclerosis in Mice

(2008) Guangyu An et al.   CIRCULATION

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events

(2008) Adam E. Mullick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment

(2008) Zahra Mamdouh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of α4β1 Integrins in Chemokine-Induced Monocyte Arrest under Conditions of Shear Stress

(2008) Sharon J. Hyduk et al.   MICROCIRCULATION

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial Domes Encapsulate Adherent Neutrophils and Minimize Increases in Vascular Permeability in Paracellular and Transcellular Emigration

(2008) Mia Phillipson et al.   PLoS One

CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor–Deficient Mice

(2007) Eva J.A. van Wanrooij et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY