Association analyses based on false discovery rate implicate new loci for coronary artery disease

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans

(2016) T. Bernard Bigdeli et al.   BIOINFORMATICS

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank

(2016) María Muñoz et al.   NATURE GENETICS

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases

(2016) O. Franzen et al.   SCIENCE

CDKN2B Regulates TGF β Signaling and Smooth Muscle Cell Investment of Hypoxic NeovesselsNovelty and Significance

(2015) Vivek Nanda et al.   CIRCULATION RESEARCH

Presenting the Epigenome Roadmap

(2015) Magdalena Skipper et al.   NATURE

The impact of low-frequency and rare variants on lipid levels

(2015) Ida Surakka et al.   NATURE GENETICS

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Functional annotation of noncoding sequence variants

(2014) Graham R S Ritchie et al.   NATURE METHODS

The contribution of genetic variants to disease depends on the ruler

(2014) John S. Witte et al.   NATURE REVIEWS GENETICS

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

The Guanine-Nucleotide Exchange Factor SGEF Plays a Crucial Role in the Formation of Atherosclerosis

(2013) Thomas Samson et al.   PLoS One

Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation

(2012) Ina Rohwedder et al.   EMBO Molecular Medicine

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Cyclic Guanosine Monophosphate Signaling and Phosphodiesterase-5 Inhibitors in Cardioprotection

(2012) Rakesh C. Kukreja et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Including known covariates can reduce power to detect genetic effects in case-control studies

(2012) Matti Pirinen et al.   NATURE GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

GWAMA: software for genome-wide association meta-analysis

(2010) Reedik Mägi et al.   BMC BIOINFORMATICS

JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles

(2009) Elodie Portales-Casamar et al.   NUCLEIC ACIDS RESEARCH

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice

(2007) Vladimir R. Babaev et al.   ATHEROSCLEROSIS