JAM-A protects from thrombosis by suppressing integrin  IIb 3-dependent outside-in signaling in platelets

Platelets at work in primary hemostasis

(2011) Katleen Broos et al.   BLOOD REVIEWS

Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling

(2011) Meghna U. Naik et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

Platelet receptors and signaling in the dynamics of thrombus formation

(2009) J. Rivera et al.   HAEMATOLOGICA

Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src

(2009) Mario M. Müller et al.   JOURNAL OF CELL BIOLOGY

Endothelial cell specific adhesion molecule (ESAM) localizes to platelet–platelet contacts and regulates thrombus formationin vivo

(2009) T. J. STALKER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3

(2009) M. U. NAIK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antithrombotic effects of targeting  IIb 3 signaling in platelets

(2008) A. J. Ablooglu et al.   BLOOD

Identification of Fc RIIa as the ITAM-bearing receptor mediating  IIb 3 outside-in integrin signaling in human platelets

(2008) B. Boylan et al.   BLOOD

CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

(2008) C. Wong et al.   BLOOD

RGT, a synthetic peptide corresponding to the integrin  3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin  IIb 3 with Src kinase

(2008) X. Su et al.   BLOOD

JAM-A is present in mammalian spermatozoa where it is essential for normal motility

(2007) Minghai Shao et al.   DEVELOPMENTAL BIOLOGY