Monocyte Recruitment, Specification, and Function in Atherosclerosis

Lineage tracing on transcriptional landscapes links state to fate during differentiation

(2020) Caleb Weinreb et al.   SCIENCE

Single Cell RNA Sequencing in Atherosclerosis Research

(2020) Jesse W. Williams et al.   CIRCULATION RESEARCH

Targeting cardiovascular inflammation: next steps in clinical translation

(2020) Patrick R Lawler et al.   EUROPEAN HEART JOURNAL

Kindlin‐3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance

(2020) Paola M. Marcovecchio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

(2020) Alma Zernecke et al.   CIRCULATION RESEARCH

Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis

(2020) Satyesh K. Sinha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

(2020) Jesse W. Williams et al.   NATURE IMMUNOLOGY

Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

(2020) Tobias Weinberger et al.   Nature Communications

Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering

(2020) Carmen Härdtner et al.   BASIC RESEARCH IN CARDIOLOGY

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

Sleep modulates haematopoiesis and protects against atherosclerosis

(2019) Cameron S. McAlpine et al.   NATURE

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Chemokines as Therapeutic Targets in Cardiovascular Disease

(2019) Heidi Noels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cytokine Circuits in Cardiovascular Disease

(2019) Jesse W. Williams et al.   IMMUNITY

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation

(2019) Tao Zhuang et al.   CIRCULATION RESEARCH

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

The Ontogeny of Monocyte Subsets

(2019) Anja A. Wolf et al.   Frontiers in Immunology

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

(2019) Stefan Jordan et al.   CELL

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

(2019) Joey Schyns et al.   Nature Communications

Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions

(2019) Sara McArdle et al.   CIRCULATION RESEARCH

Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques

(2018) Jesse W. Williams et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NR4A1 contributes to high-fat associated endothelial dysfunction by promoting CaMKII-Parkin-mitophagy pathways

(2018) Pei Li et al.   CELL STRESS & CHAPERONES

Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol ProductionNovelty and Significance

(2018) Manon Viaud et al.   CIRCULATION RESEARCH

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance

(2018) Holger Winkels et al.   CIRCULATION RESEARCH

Atherosclerosis and inflammation: overview and updates

(2018) Glaucylara Reis Geovanini et al.   CLINICAL SCIENCE

CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis

(2018) Liang Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

(2018) Delphine Gomez et al.   NATURE MEDICINE

Anti-tumor necrosis factor-α therapy increases plaque burden in a mouse model of experimental atherosclerosis

(2018) Raghav Oberoi et al.   ATHEROSCLEROSIS

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease

(2018) Jesse W. Williams et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E–deficient mice

(2017) Anja Maier et al.   FASEB JOURNAL

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

(2017) Alberto Yáñez et al.   IMMUNITY

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C − Cells

(2017) Alexander Mildner et al.   IMMUNITY

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

(2017) Amit A. Patel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control

(2017) Jenny Jongstra-Bilen et al.   JOURNAL OF IMMUNOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques ofApoE−/−MiceNovelty and Significance

(2016) Vincent Sarrazy et al.   CIRCULATION RESEARCH

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6C low Monocytes while Preserving Macrophage Gene Function

(2016) Graham D. Thomas et al.   IMMUNITY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

MHC II + resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes

(2016) Ki-Wook Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses

(2016) Shu Zhen Chong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

(2016) Olga A Cherepanova et al.   NATURE MEDICINE

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

(2016) Jaba Gamrekelashvili et al.   Nature Communications

Lifestyle Effects on Hematopoiesis and Atherosclerosis

(2015) M. Nahrendorf et al.   CIRCULATION RESEARCH

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

(2015) Sherine Ensan et al.   NATURE IMMUNOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

(2014) Leal Oburoglu et al.   Cell Stem Cell

Mechanisms That Regulate Macrophage Burden in Atherosclerosis

(2014) Gwendalyn J Randolph   CIRCULATION RESEARCH

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Chronic variable stress activates hematopoietic stem cells

(2014) Timo Heidt et al.   NATURE MEDICINE

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

(2013) Maulik D. Majmudar et al.   CIRCULATION

Liver X Receptor Activation Stimulates Iron Export in Human Alternative Macrophages

(2013) Gaël Bories et al.   CIRCULATION RESEARCH

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Distribution of macrophage polarization markers in human atherosclerosis

(2012) J. Lauran Stöger et al.   ATHEROSCLEROSIS

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

(2012) Kyrill S. Rogacev et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

Effect of CC Chemokine Receptor 2 CCR2 Blockade on Serum C-Reactive Protein in Individuals at Atherosclerotic Risk and With a Single Nucleotide Polymorphism of the Monocyte Chemoattractant Protein-1 Promoter Region

(2011) Jim Gilbert et al.   AMERICAN JOURNAL OF CARDIOLOGY

Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated Genes

(2011) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

(2011) K.-W. Kim et al.   BLOOD

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemoglobin Directs Macrophage Differentiation and Prevents Foam Cell Formation in Human Atherosclerotic Plaques

(2011) Aloke V. Finn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype

(2009) Joseph J. Boyle et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of the Migration and Survival of Monocyte Subsets by Chemokine Receptors and Its Relevance to Atherosclerosis

(2009) Emmanuel L. Gautier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

Mechanisms of Transendothelial Migration of Leukocytes

(2009) William A. Muller   CIRCULATION RESEARCH

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves

(2009) Jae-Hoon Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE