VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism

Direct multiplex imaging and optogenetics of Rho GTPases enabled by near-infrared FRET

(2018) Daria M. Shcherbakova et al.   Nature Chemical Biology

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

(2018) Tomokazu Souma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

(2018) Kevin Kruse et al.   JOURNAL OF CELL BIOLOGY

Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis

(2017) Yi-Ting Yeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

(2016) Stefanie Gurnik et al.   ACTA NEUROPATHOLOGICA

Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In VivoSignificance

(2016) Klaudia Schossleitner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ratiometric Imaging Using a Single Dye Enables Simultaneous Visualization of Rac1 and Cdc42 Activation

(2016) Christopher J. MacNevin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

(2016) Yvonne L. Dorland et al.   Nature Communications

Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction

(2015) Nazila Daneshjou et al.   JOURNAL OF CELL BIOLOGY

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells

(2015) H. Abiko et al.   JOURNAL OF CELL SCIENCE

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

(2015) Haixia Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

(2014) Jikui Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin

(2014) Haixia Gong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin

(2013) M. Vockel et al.   BLOOD

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Extracellular Signal-Regulated Kinase Regulates RhoA Activation and Tumor Cell Plasticity by Inhibiting Guanine Exchange Factor H1 Activity

(2013) Anne von Thun et al.   MOLECULAR AND CELLULAR BIOLOGY

Relevance of endothelial junctions in leukocyte extravasation and vascular permeability

(2012) Dietmar Vestweber   Annals of the New York Academy of Sciences

PKCα Activation of p120-Catenin Serine 879 Phospho-Switch Disassembles VE-Cadherin Junctions and Disrupts Vascular Integrity

(2012) Emily Vandenbroucke St Amant et al.   CIRCULATION RESEARCH

The Microtubule-Associated Rho Activating Factor GEF-H1 Interacts with Exocyst Complex to Regulate Vesicle Traffic

(2012) Ritu Pathak et al.   DEVELOPMENTAL CELL

Cadherin point mutations alter cell sorting and modulate GTPase signaling

(2012) H. Tabdili et al.   JOURNAL OF CELL SCIENCE

VE-Cadherin Signaling Induces EB3 Phosphorylation to Suppress Microtubule Growth and Assemble Adherens Junctions

(2012) Yulia A. Komarova et al.   MOLECULAR CELL

Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

(2012) Fabrizio Orsenigo et al.   Nature Communications

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

CRSBP-1/LYVE-1 ligands disrupt lymphatic intercellular adhesion by inducing tyrosine phosphorylation and internalization of VE-cadherin

(2011) W.-H. Hou et al.   JOURNAL OF CELL SCIENCE

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity

(2011) Michael T Yang et al.   Nature Protocols

Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability

(2010) Anna A. Birukova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sepsis and Endothelial Permeability

(2010) Warren L. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

VE-PTP controls blood vessel development by balancing Tie-2 activity

(2009) Mark Winderlich et al.   JOURNAL OF CELL BIOLOGY

Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo

(2009) W.-M. Heupel et al.   JOURNAL OF CELL SCIENCE

Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment

(2009) Zahra Mamdouh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Guanine Nucleotide Exchange Factor-H1 Regulates Cell Migration via Localized Activation of RhoA at the Leading Edge

(2009) Perihan Nalbant et al.   MOLECULAR BIOLOGY OF THE CELL

p120-Catenin Inhibits VE-Cadherin Internalization through a Rho-independent Mechanism

(2009) Christine M. Chiasson et al.   MOLECULAR BIOLOGY OF THE CELL

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immobilized Metal Affinity Chromatography Revisited: pH/Acid Control toward High Selectivity in Phosphoproteomics

(2008) Chia-Feng Tsai et al.   JOURNAL OF PROTEOME RESEARCH