Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis

Leukocyte arrest: Biomechanics and molecular mechanisms of β 2 integrin activation

(2016) Zhichao Fan et al.   BIORHEOLOGY

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia

(2015) A. Woodfin et al.   BLOOD

FRET detection of lymphocyte function–associated antigen-1 conformational extension

(2015) Alexandre Chigaev et al.   MOLECULAR BIOLOGY OF THE CELL

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

(2015) Merry Gunawan et al.   NATURE IMMUNOLOGY

An innate antiviral pathway acting before interferons at epithelial surfaces

(2015) Marie B Iversen et al.   NATURE IMMUNOLOGY

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration

(2015) Frederic Lagarrigue et al.   Nature Communications

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

(2015) Tovah N. Shaw et al.   PLoS Pathogens

An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2

(2014) Mehmet Sen et al.   JOURNAL OF CELL BIOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

(2014) Jun Yang et al.   Nature Communications

Impact of heating on passive and active biomechanics of suspended cells

(2014) C. J. Chan et al.   Interface Focus

JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation

(2013) Alessio Montresor et al.   JOURNAL OF CELL BIOLOGY

The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow

(2013) Anika Stadtmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2

(2013) Patricia R Taylor et al.   NATURE IMMUNOLOGY

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts

(2012) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

Interleukin-17 Cytokines Are Critical in Development of Fatal Lupus Glomerulonephritis

(2012) Prapaporn Pisitkun et al.   IMMUNITY

‘Slings’ enable neutrophil rolling at high shear

(2012) Prithu Sundd et al.   NATURE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Depletion of Dendritic Cells Enhances Innate Anti-Bacterial Host Defense through Modulation of Phagocyte Homeostasis

(2012) Stella E. Autenrieth et al.   PLoS Pathogens

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

(2010) Y. Kuwano et al.   BLOOD

Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling

(2010) Prithu Sundd et al.   NATURE METHODS

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE