Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues

Laboratory Parameters of Hemostasis, Adhesion Molecules, and Inflammation in Type 2 Diabetes Mellitus: Correlation with Glycemic Control

(2020) Eleonora Palella et al.   International Journal of Environmental Research and Public Health

Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity

(2020) Valentin Jargaud et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

A potential novel therapeutic target in diabetic retinopathy: a chemokine receptor (CCR2/CCR5) inhibitor reduces retinal vascular leakage in an animal model

(2020) Finny Monickaraj et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Endothelial Basement Membrane Components and Their Products, Matrikines: Active Drivers of Pulmonary Hypertension?

(2020) Ayse Ceren Mutgan et al.   Cells

Dendritic Cells in Subcutaneous and Epicardial Adipose Tissue of Subjects with Type 2 Diabetes, Obesity, and Coronary Artery Disease

(2019) Miloš Mráz et al.   MEDIATORS OF INFLAMMATION

Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes

(2019) Yutian Lei et al.   Frontiers in Immunology

Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

(2019) Heidi Harjunpää et al.   Frontiers in Immunology

Role of Dendritic Cells in Natural Immune Control of HIV-1 Infection

(2019) Enrique Martin-Gayo et al.   Frontiers in Immunology

High-fat diet triggers obesity-related early infiltration of macrophages into adipose tissue and transient reduction of blood monocyte count

(2019) Yanxia Liu et al.   MOLECULAR IMMUNOLOGY

Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively

(2018) Chun-Heng Kuo et al.   INTERNATIONAL JOURNAL OF OBESITY

Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders

(2018) D. Pagliari et al.   MEDIATORS OF INFLAMMATION

Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes

(2018) Carolyn F. Deacon   PEPTIDES

Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection

(2018) Daniel Kummer et al.   Cells

Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes

(2018) Juan Huang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Targeting inflammation in diabetic nephropathy: a tale of hope

(2018) Juan Antonio Moreno et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus

(2018) Tong Zhou et al.   Journal of Diabetes Research

Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration

(2017) Jasmeet S. Reyat et al.   JOURNAL OF IMMUNOLOGY

High Fat Diet Alters Gut Microbiota and the Expression of Paneth Cell-Antimicrobial Peptides Preceding Changes of Circulating Inflammatory Cytokines

(2017) Xiulan Guo et al.   MEDIATORS OF INFLAMMATION

Dual CCR2/5 Antagonist Attenuates Obesity-Induced Insulin Resistance by Regulating Macrophage Recruitment and M1/M2 Status

(2017) Ji Hye Huh et al.   Obesity

Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance

(2017) Yasutaka Miyachi et al.   Cell Reports

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration

(2017) Jian Song et al.   Cell Reports

The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System

(2017) Annie Luo et al.   Frontiers in Immunology

Circulating classical monocytes are associated with CD11c+ macrophages in human visceral adipose tissue

(2017) Kristiaan Wouters et al.   Scientific Reports

Vascular Adhesion Protein-1: A Cell Surface Amine Oxidase in Translation

(2017) Marko Salmi et al.   ANTIOXIDANTS & REDOX SIGNALING

4D intravital microscopy uncovers critical strain differences for the roles of PECAM and CD99 in leukocyte diapedesis

(2016) David P. Sullivan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Leukocyte arrest: Biomechanics and molecular mechanisms of β 2 integrin activation

(2016) Zhichao Fan et al.   BIORHEOLOGY

DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization

(2016) Fen Zhuge et al.   DIABETES

Dendritic cells and adipose tissue

(2016) Sandeep Sundara Rajan et al.   IMMUNOLOGY

Inflammatory Markers in Obese Adolescents with Type 2 Diabetes and Their Relationship to Hepatokines and Adipokines

(2016) Thomas Reinehr et al.   JOURNAL OF PEDIATRICS

Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice

(2016) Nuria Martinez et al.   MICROBES AND INFECTION

Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model

(2016) Jun Zha et al.   PLoS One

Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen

(2016) Ashkan Javid et al.   PLoS One

Modulation of Hematopoietic Chemokine Effects In Vitro and In Vivo by DPP-4/CD26

(2016) Hal E. Broxmeyer et al.   STEM CELLS AND DEVELOPMENT

Adiponectin signaling and function in insulin target tissues

(2016) Hong Ruan et al.   Journal of Molecular Cell Biology

Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes

(2016) Hung-Yuan Li et al.   PLoS One

Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve

(2015) Juliette Van Steenwinckel et al.   BRAIN BEHAVIOR AND IMMUNITY

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response

(2015) Nakisha S. Rutledge et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Glucose-dependent leukocyte activation in patients with type 2 diabetes mellitus, familial combined hyperlipidemia and healthy controls

(2015) Marijke A. de Vries et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Homeostatic regulation of T cell trafficking by a B cell–derived peptide is impaired in autoimmune and chronic inflammatory disease

(2015) Myriam Chimen et al.   NATURE MEDICINE

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

(2014) Dan Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pleiotropic Mechanisms for the Glucose-Lowering Action of DPP-4 Inhibitors

(2014) B. Omar et al.   DIABETES

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

(2014) Erin E. Mulvihill et al.   ENDOCRINE REVIEWS

Glycobiology of leukocyte trafficking in inflammation

(2014) R. D. Wright et al.   GLYCOBIOLOGY

Specific Phosphorylations Transmit Signals from Leukocyte β2to β1Integrins and Regulate Adhesion

(2014) Liisa M. Uotila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of adipose tissue immune cells in obesity and low-grade inflammation

(2014) Milos Mraz et al.   JOURNAL OF ENDOCRINOLOGY

Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function

(2014) Craig S Nunemaker et al.   JOURNAL OF ENDOCRINOLOGY

Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus

(2014) Mukesh Kumar et al.   Journal of Neuroinflammation

Contribution of Chemokine CCL2/CCR2 Signaling in the Dorsal Root Ganglion and Spinal Cord to the Maintenance of Neuropathic Pain in a Rat Model of Lumbar Disc Herniation

(2014) Xiang Zhu et al.   JOURNAL OF PAIN

Adipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells

(2014) Yanhong Chen et al.   PLoS One

Chemokine Mediated Monocyte Trafficking into the Retina: Role of Inflammation in Alteration of the Blood-Retinal Barrier in Diabetic Retinopathy

(2014) Sampathkumar Rangasamy et al.   PLoS One

Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease

(2014) Longbiao Yao et al.   Journal of Immunology Research

Diabetes Mellitus and Inflammation

(2013) Eric Lontchi-Yimagou et al.   Current Diabetes Reports

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Adipose tissue inflammation: Feeding the development of type 2 diabetes mellitus

(2013) Victoria R. Richardson et al.   IMMUNOBIOLOGY

Cutting Edge: Endothelial-Specific Gene Ablation of CD99L2 Impairs Leukocyte Extravasation In Vivo

(2013) R. Seelige et al.   JOURNAL OF IMMUNOLOGY

Membrane-type matrix metalloproteinases: key mediators of leukocyte function

(2013) Marta Marco et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance

(2013) Lianne van Beek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Getting Leukocytes to the Site of Inflammation

(2013) W. A. Muller   VETERINARY PATHOLOGY

Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy

(2013) Harvest F. Gu et al.   Frontiers in Endocrinology

B cells as effectors and regulators of autoimmunity

(2012) Eliana Mariño et al.   AUTOIMMUNITY

Vascular endothelial-cadherin and vascular stability

(2012) Elisabetta Dejana et al.   CURRENT OPINION IN HEMATOLOGY

Chemotactic cytokine receptor 5 gene polymorphism: Relevance to microvascular complications in type 2 diabetes

(2012) Monika Buraczynska et al.   CYTOKINE

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

(2012) M. Stefanovic-Racic et al.   DIABETES

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Inflammation and type 2 diabetes

(2012) M.C. Calle et al.   DIABETES & METABOLISM

Bone structure and B-cell populations, crippled by obesity, are partially rescued by brief daily exposure to low-magnitude mechanical signals

(2012) M. Ete Chan et al.   FASEB JOURNAL

Altered Polarization, Morphology, and Impaired Innate Immunity Germane to Resident Peritoneal Macrophages in Mice with Long-Term Type 2 Diabetes

(2012) Hui-Fang Liu et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

(2012) Kai Soo Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese mice

(2012) M. D. Trottier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation in the pathogenesis of microvascular complications in diabetes

(2012) Dung V. Nguyen et al.   Frontiers in Endocrinology

Mechanisms of Leukocyte Transendothelial Migration

(2011) William A. Muller   Annual Review of Pathology-Mechanisms of Disease

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

(2011) J. Shirakawa et al.   DIABETES

Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes

(2011) R. Shah et al.   DIABETES

Role of T Cells in Type 2 Diabetic Nephropathy

(2011) Chia-Chao Wu et al.   Experimental Diabetes Research

Prostaglandin D2 Regulates CD4+ Memory T Cell Trafficking across Blood Vascular Endothelium and Primes These Cells for Clearance across Lymphatic Endothelium

(2011) S. R. Ahmed et al.   JOURNAL OF IMMUNOLOGY

Docosahexaenoic Acid Inhibits the Adhesion of Flowing Neutrophils to Cytokine Stimulated Human Umbilical Vein Endothelial Cells

(2011) Clara M. Yates et al.   JOURNAL OF NUTRITION

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes

(2011) Sufyan G. Sayyed et al.   KIDNEY INTERNATIONAL

Characterization of circulating and monocyte-derived dendritic cells in obese and diabetic patients

(2011) Claudia Musilli et al.   MOLECULAR IMMUNOLOGY

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Regulation of Endothelial Cell Adhesion Molecule Expression by Mast Cells, Macrophages, and Neutrophils

(2011) Jie Zhang et al.   PLoS One

Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist

(2011) Chu-Biao Xue et al.   ACS Medicinal Chemistry Letters

PPAR-γ Agonists and Their Role in Type 2 Diabetes Mellitus Management

(2010) Valmore Bermúdez et al.   AMERICAN JOURNAL OF THERAPEUTICS

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

(2010) Joan M. Cook-Mills et al.   ANTIOXIDANTS & REDOX SIGNALING

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

(2010) Y. Kuwano et al.   BLOOD

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis

(2010) M. G. Bixel et al.   BLOOD

The dipeptidyl peptidase IV family in cancer and cell biology

(2010) Denise M. T. Yu et al.   FEBS Journal

Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia

(2010) Anne Sofie Andreasen et al.   INTENSIVE CARE MEDICINE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Vascular Cellular Adhesion Molecule-1 (VCAM-1) Expression in Mice Retinal Vessels Is Affected by Both Hyperglycemia and Hyperlipidemia

(2010) Carin Gustavsson et al.   PLoS One

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA

(2010) Elizabeth Oliver et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity

(2009) Carine Duffaut et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes

(2009) E. Tarabra et al.   DIABETES

Regulation of Inflammatory Monocyte/Macrophage Recruitment from the Bone Marrow during Murine Cytomegalovirus Infection: Role for Type I Interferons in Localized Induction of CCR2 Ligands

(2009) M. J. Crane et al.   JOURNAL OF IMMUNOLOGY

Chemokine Signaling and the Management of Neuropathic Pain

(2009) F. A. White et al.   MOLECULAR INTERVENTIONS

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil secretion products pave the way for inflammatory monocytes

(2008) O. Soehnlein et al.   BLOOD

Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees

(2008) Elisabetta Dejana et al.   CELL AND TISSUE RESEARCH

B-lymphocyte contributions to human autoimmune disease

(2008) Koichi Yanaba et al.   IMMUNOLOGICAL REVIEWS

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH