Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis

ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration

(2021) Sofia K. H. Morsing et al.   Cells

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells

(2021) Alwin de Jong et al.   Frontiers in Cardiovascular Medicine

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

(2021) Fabiana Baganha et al.   ANGIOGENESIS

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice

(2020) Laura Parma et al.   Cells

Differential Regulation of LPS-Mediated VE-Cadherin Disruption in Human Endothelial Cells and the Underlying Signaling Pathways: A Mini Review

(2020) Yee Han Chan et al.   Frontiers in Cell and Developmental Biology

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs

(2020) Charlotte Owen-Woods et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell subsets and functions in atherosclerosis

(2020) Ryosuke Saigusa et al.   Nature Reviews Cardiology

Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation

(2020) Chenghu Zhang et al.   CIRCULATION RESEARCH

Prostaglandin E2 breaks down pericyte–endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras

(2020) Carole Y. Perrot et al.   Scientific Reports

bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice

(2020) Laura Parma et al.   Scientific Reports

Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy

(2020) Fabiana Baganha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

(2020) Lena Claesson-Welsh et al.   TRENDS IN MOLECULAR MEDICINE

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword

(2019) Karin H. Simons et al.   Nature Reviews Cardiology

Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2 -Mediated Paracrine Signaling

(2019) Riikka Kivelä et al.   CIRCULATION

Mechanotransduction, immunoregulation and metabolic functions of CD31 in cardiovascular pathophysiology

(2019) Giuseppina Caligiuri   CARDIOVASCULAR RESEARCH

VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism

(2019) Vanessa V. Juettner et al.   JOURNAL OF CELL BIOLOGY

Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy

(2019) Thijs J. Beldman et al.   ACS Nano

Endothelial Response to Pathophysiological Stress

(2019) Zekun Peng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adherens junctions influence tight junction formation via changes in membrane lipid composition

(2018) Kenta Shigetomi et al.   JOURNAL OF CELL BIOLOGY

CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis

(2018) Liang Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis – Novel insights and future directions in diagnosis and therapy ,

(2018) Adam Hartley et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Identification of genomic differences among peripheral arterial beds in atherosclerotic and healthy arteries

(2018) Marja Steenman et al.   Scientific Reports

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

(2018) M. R. de Vries et al.   JOURNAL OF INTERNAL MEDICINE

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

(2018) Kevin Kruse et al.   JOURNAL OF CELL BIOLOGY

Evaluating the Efficacy of Atorvastatin on Patients with Carotid Plaque by an Innovative Ultrasonography

(2018) Yi-Cheng Zhu et al.   Journal of Stroke & Cerebrovascular Diseases

Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta

(2018) Sanne L. Maas et al.   Frontiers in Immunology

Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

(2017) Laura Parma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons

(2017) K. H. Simons et al.   JOURNAL OF INTERNAL MEDICINE

Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development

(2017) Klaus Ebnet   PHYSIOLOGICAL REVIEWS

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration

(2017) Jian Song et al.   Cell Reports

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Endothelial Cell Junctional Adhesion Molecules

(2016) Natalia Reglero-Real et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of AtherosclerosisHighlights

(2016) Annemarie Aarup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Recent insights into endothelial control of leukocyte extravasation

(2016) Peter L. Hordijk   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31)

(2016) Panida Lertkiatmongkol et al.   CURRENT OPINION IN HEMATOLOGY

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization

(2016) Margreet R. de Vries et al.   CURRENT OPINION IN LIPIDOLOGY

Modulation of endothelial function by Toll like receptors

(2016) Beatriz Salvador et al.   PHARMACOLOGICAL RESEARCH

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

(2016) Niels Heemskerk et al.   Nature Communications

Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in MiceSignificance

(2015) Sweena M. Chaudhari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation

(2015) Michael Schnoor et al.   MEDIATORS OF INFLAMMATION

T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity

(2015) Christopher V. Carman et al.   Frontiers in Immunology

Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution

(2014) Martin M.N. Schmitt et al.   ATHEROSCLEROSIS

Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space

(2014) J. Pruessmeyer et al.   BLOOD

Cause and Mechanisms of Intracranial Atherosclerosis

(2014) Katja Ritz et al.   CIRCULATION

Increased Microvascularization and Vessel Permeability Associate With Active Inflammation in Human Atheromata

(2014) Viviany R. Taqueti et al.   Circulation-Cardiovascular Imaging

Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF

(2014) Michaela Finsterbusch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Programmed Cell Death-1 Deficiency Exacerbates T Cell Activation and Atherogenesis despite Expansion of Regulatory T Cells in Atherosclerosis-Prone Mice

(2014) Clément Cochain et al.   PLoS One

Rho GAPs and GEFs

(2014) Jaap D van Buul et al.   Cell Adhesion & Migration

Red blood cell, hemoglobin and heme in the progression of atherosclerosis

(2014) Viktória Jeney et al.   Frontiers in Physiology

The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment

(2013) Matthew Harrison et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis

(2013) Martin M.N. Schmitt et al.   CIRCULATION

An immunologist's guide to CD31 function in T-cells

(2013) F. M. Marelli-Berg et al.   JOURNAL OF CELL SCIENCE

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

(2013) Roland Klingenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

The Guanine-Nucleotide Exchange Factor SGEF Plays a Crucial Role in the Formation of Atherosclerosis

(2013) Thomas Samson et al.   PLoS One

Macrophages Transmit Potent Proangiogenic Effects of oxLDL In Vitro and In Vivo Involving HIF-1α Activation: a Novel Aspect of Angiogenesis in Atherosclerosis

(2013) Randolph Hutter et al.   Journal of Cardiovascular Translational Research

Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems

(2012) Yoshiki Matsuo et al.   ATHEROSCLEROSIS

Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice

(2012) Jong-Gil Park et al.   ATHEROSCLEROSIS

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation

(2012) Jos van Rijssel et al.   MOLECULAR BIOLOGY OF THE CELL

Plaque Rupture Complications in Murine Atherosclerotic Vein Grafts Can Be Prevented by TIMP-1 Overexpression

(2012) Margreet R. de Vries et al.   PLoS One

Toll-Like Receptor 4 Is Involved in Human and Mouse Vein Graft Remodeling, and Local Gene Silencing Reduces Vein Graft Disease in Hypercholesterolemic APOE*3Leiden Mice

(2011) Jacco C. Karper et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Intravital Microscopy on Atherosclerosis in Apolipoprotein E–Deficient Mice Establishes Microvessels as Major Entry Pathways for Leukocytes to Advanced Lesions

(2011) Einar E. Eriksson   CIRCULATION

Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

(2011) Sajesh Parathath et al.   CIRCULATION RESEARCH

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers

(2011) Ronen Alon et al.   EXPERIMENTAL CELL RESEARCH

Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity

(2011) J. R. Privratsky et al.   JOURNAL OF CELL SCIENCE

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis

(2010) Emőke Nagy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Disintegrin and Metalloprotease 10 Is a Novel Mediator of Vascular Endothelial Growth Factor–Induced Endothelial Cell Function in Angiogenesis and Is Associated With Atherosclerosis

(2010) Marjo M.P.C. Donners et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome

(2010) Willem E. Hellings et al.   CIRCULATION

LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ

(2010) R. Sumagin et al.   JOURNAL OF IMMUNOLOGY

TCR Stimulation Drives Cleavage and Shedding of the ITIM Receptor CD31

(2010) G. Fornasa et al.   JOURNAL OF IMMUNOLOGY

Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype

(2009) Joseph J. Boyle et al.   AMERICAN JOURNAL OF PATHOLOGY

ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries—Tampere vascular study

(2009) Niku Oksala et al.   ANNALS OF MEDICINE

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1

(2009) A. Woodfin et al.   BLOOD

JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling

(2009) M. R. Cera et al.   JOURNAL OF CELL SCIENCE

Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis

(2009) Judith C Sluimer et al.   JOURNAL OF PATHOLOGY

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Molecular mechanisms underlying the activation of eNOS

(2009) Ingrid Fleming   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice

(2008) Reema Goel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice

(2008) Brian L. Harry et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

(2008) Andrew C. Newby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1

(2008) C. Garnacho et al.   BLOOD

Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees

(2008) Elisabetta Dejana et al.   CELL AND TISSUE RESEARCH

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1

(2008) Marie-Pierre Simon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?

(2008) B. M. Maher et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases

(2008) J. M. van Gils et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis

(2008) Judith C. Sluimer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY

Differential distribution of vasa vasorum in different vascular beds in humans

(2007) Heike A. Hildebrandt et al.   ATHEROSCLEROSIS