Recent insights into the cellular biology of atherosclerosis

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Alternative Splicing of Endothelial Fibronectin Is Induced by Disturbed Hemodynamics and Protects Against Hemorrhage of the Vessel Wall

(2014) Patrick A. Murphy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

(2014) Jing Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel Mechanisms of Endothelial Mechanotransduction

(2014) Jun-ichi Abe et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1

(2014) Jing Zhou et al.   Cellular and Molecular Bioengineering

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation

(2014) Marit Westerterp et al.   CIRCULATION RESEARCH

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

(2014) Peter Libby et al.   CIRCULATION RESEARCH

Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 Promoter In Vitro and In Vivo

(2014) Yi-Zhou Jiang et al.   CIRCULATION RESEARCH

Inflammasome and Atherogenesis

(2014) Xinjie Lu et al.   CURRENT PHARMACEUTICAL DESIGN

Activation of the Proapoptotic Unfolded Protein Response in Plaques of the Human Carotid Artery

(2014) B. Dorweiler et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis

(2014) Jessilyn Dunn et al.   JOURNAL OF CLINICAL INVESTIGATION

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production

(2014) Sudheer K. Pabbisetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

(2014) Nicolas Baeyens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression

(2014) Michael Peled et al.   Frontiers in Immunology

Cholesterol Efflux Pathways Regulate Myelopoiesis: A Potential Link to Altered Macrophage Function in Atherosclerosis

(2014) Andrew James Murphy et al.   Frontiers in Immunology

Kruppel-Like Factor 2 Regulates Dendritic Cell Activation in Patients with Acute Coronary Syndrome

(2013) Hongcheng Fang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages

(2013) Ying Wang et al.   CIRCULATION RESEARCH

Mechanosensitive microRNAs—role in endothelial responses to shear stress and redox state

(2013) Traci Marin et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress

(2013) Yunhao Liu et al.   JOURNAL OF CELL BIOLOGY

Flow-dependent cellular mechanotransduction in atherosclerosis

(2013) D. E. Conway et al.   JOURNAL OF CELL SCIENCE

Collagenases and cracks in the plaque

(2013) Peter Libby   JOURNAL OF CLINICAL INVESTIGATION

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Detection of histone modifications at specific gene loci in single cells in histological sections

(2013) Delphine Gomez et al.   NATURE METHODS

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

(2013) Juan Lin et al.   Cell Reports

Interplay Between NF‐κB and Kruppel‐like Factors in Vascular Inflammation and Atherosclerosis: Location, Location, Location

(2013) G. Brandon Atkins et al.   Journal of the American Heart Association

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

(2012) Andrew Koo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Myeloid Krüppel-Like Factor 4 Deficiency Augments Atherogenesis in ApoE −/− Mice—Brief Report

(2012) Nikunj Sharma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis

(2012) Michael A. Gimbrone et al.   CARDIOVASCULAR PATHOLOGY

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids?

(2012) Ulisse Garbin et al.   CARDIOVASCULAR RESEARCH

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Myeloid-Specific Krüppel-Like Factor 2 Inactivation Increases Macrophage and Neutrophil Adhesion and Promotes Atherosclerosis

(2012) Jerry B Lingrel et al.   CIRCULATION RESEARCH

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Update on acute coronary syndromes: the pathologists' view

(2012) Erling Falk et al.   EUROPEAN HEART JOURNAL

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice

(2012) Guangjin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardial infarction accelerates atherosclerosis

(2012) Partha Dutta et al.   NATURE

Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease

(2011) Matthew R. Alexander et al.   Annual Review of Physiology

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis

(2011) Edward Thorp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

(2011) Matthew R. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

(2011) M. B. Fessler et al.   JOURNAL OF IMMUNOLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Bone Marrow–Derived Cells Contribute to Vascular Inflammation but Do Not Differentiate Into Smooth Muscle Cell Lineages

(2010) Hiroshi Iwata et al.   CIRCULATION

Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation

(2010) Ryan E. Feaver et al.   CIRCULATION RESEARCH

Erk5 Activation Elicits a Vasoprotective Endothelial Phenotype via Induction of Krüppel-like Factor 4 (KLF4)

(2010) Nils Ohnesorge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statin-induced Kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses

(2010) De-xiu Bu et al.   JOURNAL OF CLINICAL INVESTIGATION

Kruppel-Like Factor 2 Is Required for Trafficking but Not Quiescence in Postactivated T Cells

(2010) K. Takada et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

(2009) Guadalupe Villarreal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

Thrombin Stimulates Smooth Muscle Cell Differentiation From Peripheral Blood Mononuclear Cells via Protease-Activated Receptor-1, RhoA, and Myocardin

(2009) Kenneth Martin et al.   CIRCULATION RESEARCH

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

(2009) Mete Civelek et al.   CIRCULATION RESEARCH

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

(2009) Abigail S. Haka et al.   MOLECULAR BIOLOGY OF THE CELL

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

(2008) James A. Thomas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hemizygous Deficiency of Krüppel-Like Factor 2 Augments Experimental Atherosclerosis

(2008) G. Brandon Atkins et al.   CIRCULATION RESEARCH

Conditional Deletion of Krüppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury

(2008) Tadashi Yoshida et al.   CIRCULATION RESEARCH

Substrate-induced phenotypical change of monocytes/macrophages into myofibroblast-like cells: A new insight into the mechanism of in-stent restenosis

(2008) H. J. S. Stewart et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events

(2008) Adam E. Mullick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The molecular mechanisms of the thrombotic complications of atherosclerosis

(2008) P. Libby   JOURNAL OF INTERNAL MEDICINE

Impaired glycocalyx barrier properties contribute to enhanced intimal low-density lipoprotein accumulation at the carotid artery bifurcation in mice

(2008) Bernard M. van den Berg et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY