L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

Molecular Dynamics of the Association of L-Selectin and FERM Regulated by PIP2

(2018) Fude Sun et al.   BIOPHYSICAL JOURNAL

A head-to-tail view of L-selectin and its impact on neutrophil behaviour

(2018) Aleksandar Ivetic   CELL AND TISSUE RESEARCH

Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration

(2018) Angela Rey-Gallardo et al.   JOURNAL OF CELL SCIENCE

Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminatingStaphylococcus aureus

(2018) Ania Bogoslowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

(2018) Joseph Kononchik et al.   Nature Communications

Dual regulation of L-selectin (CD62L) by HIV-1: Enhanced expression by Vpr in contrast with cell-surface down-modulation by Nef and Vpu

(2018) Erica Giuliani et al.   VIROLOGY

Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages

(2018) Kristin Schultz et al.   PLoS One

A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

(2018) Libing Mu et al.   Nature Communications

Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels

(2018) Vasilios A. Morikis et al.   Frontiers in Immunology

The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif

(2017) Karim Dib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

(2017) Amit A. Patel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treg therapy in transplantation: a general overview

(2017) Marco Romano et al.   TRANSPLANT INTERNATIONAL

PSGL-1: A New Player in the Immune Checkpoint Landscape

(2017) Roberto Tinoco et al.   TRENDS IN IMMUNOLOGY

L-selectin mechanochemistry restricts neutrophil priming in vivo

(2017) Zhenghui Liu et al.   Nature Communications

Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism

(2017) Thaher Pelaseyed et al.   eLife

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

(2017) Emily Jayne Colbeck et al.   Frontiers in Immunology

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

(2017) Ann Ager   Frontiers in Immunology

L-selectin Is Essential for Delivery of Activated CD8 + T Cells to Virus-Infected Organs for Protective Immunity

(2016) Rebar N. Mohammed et al.   Cell Reports

Nonclassical Patrolling Monocyte Function in the Vasculature

(2015) G. Thomas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel splice variant of human L-selectin encodes a soluble molecule that is elevated in serum of patients with rheumatic diseases

(2015) Takako Hirata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+T Lymphocytes

(2015) Lia Vassena et al.   JOURNAL OF VIROLOGY

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro

(2015) Karolina Rzeniewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

(2015) Monika Pruenster et al.   Nature Communications

The non-muscle functions of actinins: an update

(2014) Kate S. Foley et al.   BIOCHEMICAL JOURNAL

Ezrin and Moesin Function Together to Promote T Cell Activation

(2014) M. H. Shaffer et al.   JOURNAL OF IMMUNOLOGY

Suppression of Foxo1 Activity and Down-Modulation of CD62L (L-Selectin) in HIV-1 Infected Resting CD4 T Cells

(2014) Benjamin Trinité et al.   PLoS One

L-selectin deficiency decreases aortic B1a and Breg subsets and promotes atherosclerosis

(2014) Breanne Gjurich et al.   THROMBOSIS AND HAEMOSTASIS

An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle α-actinins

(2013) Kate S. Foley et al.   BIOCHEMICAL JOURNAL

Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

(2013) L. Westera et al.   BLOOD

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Over-sulfated glycosaminoglycans are alternative selectin ligands: insights into molecular interactions and possible role in breast cancer metastasis

(2013) Pierre Martinez et al.   CLINICAL & EXPERIMENTAL METASTASIS

Signals regulating L-selectin-dependent leucocyte adhesion and transmigration

(2013) Aleksandar Ivetic   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transient PKC  shuttling to the immunological synapse is governed by DGK  and regulates L-selectin shedding

(2013) S. I. Gharbi et al.   JOURNAL OF CELL SCIENCE

The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow

(2013) Anika Stadtmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FERM Domain of Moesin Desorbs the Basic-Rich Cytoplasmic Domain of l-Selectin from the Anionic Membrane Surface

(2013) Wei Deng et al.   JOURNAL OF MOLECULAR BIOLOGY

Calmodulin Adopts an Extended Conformation when Interacting with L-Selectin in Membranes

(2013) Wei Deng et al.   PLoS One

On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction

(2013) Greg A. Foster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of L-Selectin Stimulation of the Expression of Chemokine Receptor CXCR4 on NK Cells of Healthy Donors and Tumor Patients

(2012) Yu. V. Perfilyeva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis

(2012) T. Hirata et al.   INTERNATIONAL IMMUNOLOGY

Silencing α1,3-Fucosyltransferases in Human Leukocytes Reveals a Role for FUT9 Enzyme during E-selectin-mediated Cell Adhesion

(2012) Alexander Buffone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Calmodulin-regulated L-selectin Ectodomain Shedding

(2012) Jessica L. Gifford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling through L-Selectin Mediates Enhanced Chemotaxis of Lymphocyte Subsets to Secondary Lymphoid Tissue Chemokine

(2012) H. Subramanian et al.   JOURNAL OF IMMUNOLOGY

ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment

(2012) C. Long et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

(2012) Lisa A Kohn et al.   NATURE IMMUNOLOGY

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo

(2012) B. Stolp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH

(2011) Mayumi Hirose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites

(2011) J. Tang et al.   BLOOD

Intravital Microscopy on Atherosclerosis in Apolipoprotein E–Deficient Mice Establishes Microvessels as Major Entry Pathways for Leukocytes to Advanced Lesions

(2011) Einar E. Eriksson   CIRCULATION

Enrichment of Functionally Distinct Mouse Hematopoietic Progenitor Cell Populations Using CD62L

(2011) Scott Cho et al.   JOURNAL OF IMMUNOLOGY

Architecture effects on L-selectin shedding induced by polypeptide-based multivalent ligands

(2011) Shuang Liu et al.   Polymer Chemistry

Rolling Cell Adhesion

(2010) Rodger P. McEver et al.   Annual Review of Cell and Developmental Biology

The cytoplasmic domains of TNFα-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding

(2010) David J. Killock et al.   BIOCHEMICAL JOURNAL

Triphasic Force Dependence of E-Selectin/Ligand Dissociation Governs Cell Rolling under Flow

(2010) Annica M. Wayman et al.   BIOPHYSICAL JOURNAL

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

CD62Lhigh Treg cells with superior immunosuppressive properties accumulate within the CNS during remissions of EAE

(2010) Christian Lange et al.   BRAIN BEHAVIOR AND IMMUNITY

The Transmembrane Domains of L-selectin and CD44 Regulate Receptor Cell Surface Positioning and Leukocyte Adhesion under Flow

(2010) Konrad Buscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Glycan Analysis of Recombinant L-Selectin Reveals Sulfated GalNAc and GalNAc−GalNAc Motifs

(2010) Stefanie Wedepohl et al.   JOURNAL OF PROTEOME RESEARCH

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors

(2009) O. Sobolev et al.   CANCER RESEARCH

PSGL-1 function in immunity and steady state homeostasis

(2009) Douglas A. Carlow et al.   IMMUNOLOGICAL REVIEWS

Cyclical expression of L-selectin (CD62L) by recirculating T cells

(2009) A. Klinger et al.   INTERNATIONAL IMMUNOLOGY

In Vitroandin VivoCharacterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin

(2009) David J. Killock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

(2009) Sylvain M. Le Gall et al.   MOLECULAR BIOLOGY OF THE CELL

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

(2009) Yann M Kerdiles et al.   NATURE IMMUNOLOGY

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation

(2009) N. V. Belkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional regulation of mouse l-selectin

(2008) Xitong Dang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation

(2008) A. Shigeta et al.   BLOOD

Identification of Novel Isoforms of Mouse L-selectin with Different Carboxyl-terminal Tails

(2008) Yuko Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(−) natural killer cells into human endometrium

(2008) Kotaro Kitaya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes

(2008) I. Ahrens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Critical role of Lck in L-selectin signaling induced by sulfatides engagement

(2008) Ting Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules

(2008) Einar E. Eriksson   JOURNAL OF LEUKOCYTE BIOLOGY

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY