Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

(2021) Hagai Rottenberg et al.   Cells

Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers

(2021) Andre F. Batista et al.   Journal of Neuroinflammation

Role of microglial and endothelial CD36 in post-ischemic inflammasome activation and interleukin-1β-induced endothelial activation

(2021) Lidia Garcia-Bonilla et al.   BRAIN BEHAVIOR AND IMMUNITY

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

(2021) Sandro Da Mesquita et al.   NATURE

Microvascular Degeneration Occurs Before Plaque Onset and Progresses with Age in 3xTg AD Mice

(2021) Dominic D. Quintana et al.   NEUROBIOLOGY OF AGING

Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway

(2021) Qin Zhang et al.   Oxidative Medicine and Cellular Longevity

Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer’s disease pathology in aged squirrel monkeys

(2021) Akash G Patel et al.   BRAIN

Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment

(2021) Haruki Koike et al.   MOLECULES

Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease

(2021) Xiao-Wen Ding et al.   PHARMACOLOGICAL RESEARCH

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

(2020) Benjamin C. Reeves et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes

(2020) Camila A. Pereira et al.   Frontiers in Physiology

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

Alzheimer’s Disease: The Link Between Amyloid-β and Neurovascular Dysfunction

(2020) Ernesto Solis et al.   JOURNAL OF ALZHEIMERS DISEASE

MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH

(2020) Weixiang Chen et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes

(2020) Francesca Iannantuoni et al.   Journal of Clinical Medicine

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

(2020) Chien-Hsiung Yu et al.   CELL

Glymphatic failure as a final common pathway to dementia

(2020) Maiken Nedergaard et al.   SCIENCE

NLRP3 inflammasome in endothelial dysfunction

(2020) Baochen Bai et al.   Cell Death & Disease

Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging

(2020) Nicholas E. Propson et al.   JOURNAL OF CLINICAL INVESTIGATION

CD36 in Alzheimer’s Disease: An Overview of Molecular Mechanisms and Therapeutic Targeting

(2020) Ana-Maria Dobri et al.   NEUROSCIENCE

Cathepsin B is an executioner of ferroptosis

(2020) Pandian Nagakannan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Multilevel View of the Development of Alzheimer’s Disease

(2020) Jesús Avila et al.   NEUROSCIENCE

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

(2019) Whitney M. Freeze et al.   STROKE

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function

(2019) Adam L. Orr et al.   JOURNAL OF ALZHEIMERS DISEASE

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

(2019) Yu Yamazaki et al.   BRAIN

The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation

(2019) Ekta Bajwa et al.   MEDIATORS OF INFLAMMATION

Organization of DNA in Mammalian Mitochondria

(2019) Géraldine Farge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

(2019) Rebecca Parodi-Rullán et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrovascular inflammation: A critical trigger for neurovascular injury?

(2019) Muhammad Naveed et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondria at the interface between neurodegeneration and neuroinflammation

(2019) Verian Bader et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model

(2019) Simona Federica Spampinato et al.   Frontiers in Cellular Neuroscience

ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology

(2019) Yongliang Cao et al.   PLOS BIOLOGY

A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer’s Disease

(2019) Gustavo Provensi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia

(2019) Yunan Mo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells

(2019) Yang Long et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

(2019) Weixing Zhao et al.   Journal of Neuroinflammation

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling

(2019) Sehwan Jang et al.   MITOCHONDRION

Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

(2019) Susanne J. van Veluw et al.   NEURON

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice

(2018) Stefano Tarantini et al.   AGING CELL

Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity

(2018) María E. Solesio et al.   AGING CELL

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment

(2018) Candice E. Van Skike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

(2018) Erwin Cabrera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ 1-42 induces cell damage via RAGE-dependent endoplasmic reticulum stress in bEnd.3 cells

(2018) Wenjing Chen et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer’s Disease

(2018) Carola Stockburger et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Mitochondrial permeability transition pore: a potential drug target for neurodegeneration

(2018) Komal Kalani et al.   DRUG DISCOVERY TODAY

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

A New Paradigm for the Treatment of Alzheimer's Disease: Targeting Vascular Activation

(2018) Paula Grammas et al.   JOURNAL OF ALZHEIMERS DISEASE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

(2018) Junjun Ni et al.   AGING CELL

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET

(2017) Mony J. de Leon et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral Amyloid Angiopathy

(2017) Christopher V. DeSimone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity

(2017) Juhyun Song et al.   Cell Death & Disease

Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease

(2017) Illsung L. Joo et al.   Scientific Reports

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits

(2016) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study

(2016) Zoe Arvanitakis et al.   LANCET NEUROLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging

(2016) Harm J. van de Haar et al.   NEUROBIOLOGY OF AGING

The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain

(2016) Silvia Fossati et al.   NEUROBIOLOGY OF DISEASE

Schwann cell and endothelial cell damage in transthyretin familial amyloid polyneuropathy

(2016) Haruki Koike et al.   NEUROLOGY

Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis

(2016) Yoshiki Sekijima et al.   NEUROLOGY

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium

(2016) Roman A. Zinovkin et al.   Aging-US

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

(2015) Amandine Grimm et al.   BIOGERONTOLOGY

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

(2015) Sudeshna Roy et al.   ChemMedChem

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease

(2015) Heather M. Wilkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Involvement of cathepsin B in mitochondrial apoptosis by p -phenylenediamine under ambient UV radiation

(2015) Shruti Goyal et al.   JOURNAL OF HAZARDOUS MATERIALS

Aβ1-42oligomer-induced leakage in anin vitroblood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins

(2015) Wenbin Wan et al.   JOURNAL OF NEUROCHEMISTRY

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Mitochondrial Crisis in Cerebrovascular Endothelial Cells Opens the Blood–Brain Barrier

(2015) Danielle N. Doll et al.   STROKE

Clinical significance of circulating vascular cell adhesion molecule-1 to white matter disintegrity in Alzheimer’s dementia

(2015) Chi-Wei Huang et al.   THROMBOSIS AND HAEMOSTASIS

NLRP3 Mediates NF-κB Activation and Cytokine Induction in Microbially Induced and Sterile Inflammation

(2015) Takeshi Kinoshita et al.   PLoS One

Functional role of NF-κB in expression of human endothelial nitric oxide synthase

(2014) Kyu-Sun Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood–brain barrier model

(2014) Hisham Qosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore

(2014) T. Song et al.   GENETICS AND MOLECULAR RESEARCH

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

(2014) Jonathan P. Little et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

(2014) Yue Wang et al.   PLoS One

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

(2014) Laibaik Park et al.   STROKE

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

(2014) Lee J. Martin et al.   Frontiers in Cellular Neuroscience

Amyloid β and Tau Alzheimer’s disease related pathology is reduced by Toll-like receptor 9 stimulation

(2014) Henrieta Scholtzova et al.   Acta Neuropathologica Communications

Impact of Apolipoprotein E on Alzheimer’s Disease

(2013) Paul Hauser et al.   Current Alzheimer Research

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

The development of cerebral amyloid angiopathy in cerebral vessels. A review with illustrations based upon own investigated post mortem cases

(2013) Tadeusz Andrzej Mendel et al.   POLISH JOURNAL OF PATHOLOGY

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

(2013) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia

(2013) Debjani Tripathy et al.   Frontiers in Aging Neuroscience

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease

(2012) Dongzi Yu et al.   NEUROBIOLOGY OF AGING

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer’s Aβ

(2012) S Fossati et al.   Cell Death & Disease

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

TNF-alpha induced NFκB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells

(2011) Muhammad Aslam et al.   CYTOKINE

Inhibition of VCAM-1 expression in endothelial cells by CORM-3: The role of the ubiquitin–proteasome system, p38, and mitochondrial respiration

(2011) Claudia Bergstraesser et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Inflammatory Response to Double Stranded DNA in Endothelial Cells Is Mediated by NFκB and TNFα

(2011) Suraj J. Patel et al.   PLoS One

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells

(2010) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Mitochondrial Superoxide Contributes to Blood Flow and Axonal Transport Deficits in the Tg2576 Mouse Model of Alzheimer's Disease

(2010) Cynthia A. Massaad et al.   PLoS One

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia

(2009) Noriko Sumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls

(2009) S. Fossati et al.   FASEB JOURNAL

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

LFA-1 Affinity Regulation Is Necessary for the Activation and Proliferation of Naive T Cells

(2009) Yang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bacterial DNA Activates Endothelial Cells and Promotes Neutrophil Adherence through TLR9 Signaling

(2009) D. El Kebir et al.   JOURNAL OF IMMUNOLOGY

Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathyin vivoin transgenic mice

(2009) Monica Garcia-Alloza et al.   JOURNAL OF NEUROCHEMISTRY

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

(2009) H. Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

(2009) Toshiyuki Nakamura et al.   Molecular Neurodegeneration

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation

(2009) Bernhard Schweighofer et al.   THROMBOSIS AND HAEMOSTASIS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-κB activation in endothelial cells

(2008) Su-Ryun Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Inhibitors of Cytochrome c Release with Therapeutic Potential for Huntington's Disease

(2008) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia

(2008) G. Zuliani et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE