Cathepsin B is an executioner of ferroptosis

Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

(2020) Yishu Wang et al.   FEBS Open Bio

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease

(2019) Lin Cong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease

(2019) Md Imamul Islam et al.   FREE RADICAL BIOLOGY AND MEDICINE

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

(2019) Xueying Guan et al.   LIFE SCIENCES

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

(2018) Michael M. Gaschler et al.   ACS Chemical Biology

Ferroptosis is a lysosomal cell death process

(2018) Huan Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of lipid peroxidation and ferroptosis in diverse species

(2018) Marcus Conrad et al.   GENES & DEVELOPMENT

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Lysosomal membrane permeabilization and cell death

(2018) Fengjuan Wang et al.   TRAFFIC

Inhibition of VDAC1 Protects Against Glutamate-Induced Oxytosis and Mitochondrial Fragmentation in Hippocampal HT22 Cells

(2018) Pandian Nagakannan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells

(2017) Pandian Nagakannan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lysosomal Permeabilization Facilitate Mitochondria-mediated Cell Death in Ferroptosis and Oxytosis

(2017) Nagakannan Pandian et al.   FREE RADICAL BIOLOGY AND MEDICINE

The α6β4 integrin promotes resistance to ferroptosis

(2017) Caitlin W. Brown et al.   JOURNAL OF CELL BIOLOGY

An acidic pH independent piperazine–TPE AIEgen as a unique bioprobe for lysosome tracing

(2017) Yuanjing Cai et al.   Chemical Science

Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells

(2017) Shihui Hao et al.   NEOPLASIA

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx

(2016) Michael A. Katsnelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

STAT3 signaling in immunity

(2016) Emily J. Hillmer et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells

(2016) Pandian Nagakannan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

(2016) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

News about VDAC1 in Hypoxia

(2016) N. M. Mazure   Frontiers in Oncology

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Lysosomal proteins in cell death and autophagy

(2015) Michaela Mrschtik et al.   FEBS Journal

Local Mitochondrial-Endolysosomal Microfusion Cleaves Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia

(2015) M. Christiane Brahimi-Horn et al.   MOLECULAR AND CELLULAR BIOLOGY

Release of mitochondrial Opa1 following oxidative stress in HT22 cells

(2015) Thomas H. Sanderson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

(2015) Paul S. Baxter et al.   Nature Communications

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

(2015) Gregory Hook et al.   Frontiers in Neurology

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Cleavage of Histone 3 by Cathepsin D in the Involuting Mammary Gland

(2014) Zhila Khalkhali-Ellis et al.   PLoS One

Identification of histone H3 clipping activity in human embryonic stem cells

(2014) Liesbeth Vossaert et al.   Stem Cell Research

LYST Affects Lysosome Size and Quantity, but not Trafficking or Degradation Through Autophagy or Endocytosis

(2014) Petter Holland et al.   TRAFFIC

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

(2013) Lee S. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation

(2013) Tobias Jung et al.   Redox Biology

Identification of a novel histone H3 specific protease activity in nuclei of chicken liver

(2012) Papita Mandal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutathione and modulation of cell apoptosis

(2012) Magdalena L. Circu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of Macrophage-Secreted Cathepsin B Contributes to HIV-1-Linked Neuronal Apoptosis

(2012) Eillen J. Rodriguez-Franco et al.   PLoS One

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target

(2012) Thomas Reinheckel et al.   Frontiers in Pharmacology

The role of lysosomes in iron metabolism and recycling

(2011) Tino Kurz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chaperone-mediated autophagy at a glance

(2011) S. Kaushik et al.   JOURNAL OF CELL SCIENCE

Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor

(2011) Yoko Hirata et al.   JOURNAL OF NEUROCHEMISTRY

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

(2011) Emma Sandilands et al.   NATURE CELL BIOLOGY

Cystatin C Rescues Degenerating Neurons in a Cystatin B-Knockout Mouse Model of Progressive Myoclonus Epilepsy

(2010) Gurjinder Kaur et al.   AMERICAN JOURNAL OF PATHOLOGY

Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo

(2010) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

(2010) N. Keinan et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells

(2009) Masayuki Fukui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

(2009) Chisato Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secondary lipid accumulation in lysosomal disease

(2008) Steven U. Walkley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation

(2008) Elizabeth M. Duncan et al.   CELL

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY