Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer’s disease pathology in aged squirrel monkeys

Passive antiamyloid immunotherapy for Alzheimerʼs disease

(2020) Júlia C. Loureiro et al.   CURRENT OPINION IN PSYCHIATRY

Alzheimer’s disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation

(2020) Shehata Anwar et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Braak Stage, Cerebral Amyloid Angiopathy, and Cognitive Decline in Early Alzheimer’s Disease

(2020) Michael Malek-Ahmadi et al.   JOURNAL OF ALZHEIMERS DISEASE

Current State of Anthrax Vaccines and Key R&D Gaps Moving Forward

(2020) Adam Clark et al.   Microorganisms

Shifting paradigms: The central role of microglia in Alzheimer's disease

(2020) Tina Schwabe et al.   NEUROBIOLOGY OF DISEASE

Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk

(2019) Amanda McQuade et al.   JOURNAL OF MOLECULAR BIOLOGY

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

(2019) Pierre Dourlen et al.   ACTA NEUROPATHOLOGICA

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

(2019) Dawling A. Dionisio-Santos et al.   Journal of Neuroinflammation

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions

(2019) David R. Elmaleh et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Cerebral amyloid angiopathy: diagnosis and potential therapies

(2018) Stewart A. Weber et al.   Expert Review of Neurotherapeutics

Recent advancements toward therapeutic vaccines against alzheimer’s disease

(2018) Krystal Herline et al.   Expert Review of Vaccines

Potential Novel Approaches to Understand the Pathogenesis and Treat Alzheimer’s Disease

(2018) Eleanor Drummond et al.   JOURNAL OF ALZHEIMERS DISEASE

Generation and Partial Characterization of Rabbit Monoclonal Antibody to Pyroglutamate Amyloid-β3-42 (pE3-Aβ)

(2018) Pankaj D. Mehta et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer’s disease model

(2018) Fernando Goñi et al.   Alzheimers Research & Therapy

Cerebral amyloid angiopathy: diagnosis and potential therapies

(2018) Stewart A. Weber et al.   Expert Review of Neurotherapeutics

Blocking the Apolipoprotein E/Amyloid-β Interaction Reduces Fibrillar Vascular Amyloid Deposition and Cerebral Microhemorrhages in TgSwDI Mice

(2018) Jing Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

CpG Still Rocks! Update on an Accidental Drug

(2018) Arthur M. Krieg   Nucleic Acid Therapeutics

IgM response against amyloid-beta in aging: a potential peripheral protective mechanism

(2018) Sudhanshu Agrawal et al.   Alzheimers Research & Therapy

Cellular immune responses in peripheral blood lymphocytes of Giardia infected squirrel monkey (Saimiri boliviensis boliviensis) treated with Fenbendazole

(2018) Pramod N. Nehete et al.   PLoS One

Amyloid-Related Imaging Abnormalities in an Aged Squirrel Monkey with Cerebral Amyloid Angiopathy

(2017) Eric Heuer et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Let’s make microglia great again in neurodegenerative disorders

(2017) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF NEURAL TRANSMISSION

Cerebral amyloid angiopathy as a cause of neurodegeneration

(2017) Eric E. Smith   JOURNAL OF NEUROCHEMISTRY

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

(2017) Gargi Banerjee et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Immunomodulation via Toll-like Receptor 9: An Adjunct Therapy Strategy against Alzheimer's Disease?

(2017) Maria Clara Selles et al.   JOURNAL OF NEUROSCIENCE

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

(2017) Kathryn P. MacPherson et al.   NEUROBIOLOGY OF DISEASE

Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

(2017) Isabelle Bos et al.   Alzheimers Research & Therapy

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system

(2016) Khalil S. Rawji et al.   BRAIN

Reprint of: Microglial toll-like receptors and Alzheimer’s disease

(2016) Fan Su et al.   BRAIN BEHAVIOR AND IMMUNITY

Amyloid-Related Imaging Abnormalities (ARIA) in Immunotherapy Trials for Alzheimer’s Disease: Need for Prognostic Biomarkers?

(2016) Fabrizio Piazza et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting innate immunity for neurodegenerative disorders of the central nervous system

(2016) Katrin I. Andreasson et al.   JOURNAL OF NEUROCHEMISTRY

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-  Oligomers in Mice

(2016) J. H. Ledo et al.   JOURNAL OF NEUROSCIENCE

Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits

(2016) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

(2016) Holger Cynis et al.   Molecular Neurodegeneration

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Comparative pathobiology of β-amyloid and the unique susceptibility of humans to Alzheimer's disease

(2016) Rebecca F. Rosen et al.   NEUROBIOLOGY OF AGING

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

(2015) Maike Hartlage-Rübsamen et al.   ACTA NEUROPATHOLOGICA

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice

(2015) Stefan Prokop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Why bother using non-human primate models of cognitive disorders in translational research?

(2015) Sandrine Camus et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

(2015) Patricia A. Boyle et al.   NEUROLOGY

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer’s Disease-Related Pathology

(2015) Jean-Philippe Michaud et al.   NEURON

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

(2014) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

(2014) Julia Scheiermann et al.   VACCINE

Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization

(2013) Elina Zotova et al.   BRAIN

A Comparison of Positive Reinforcement Training Techniques in Owl and Squirrel Monkeys: Time Required to Train to Reliability

(2013) Jessica Rogge et al.   JOURNAL OF APPLIED ANIMAL WELFARE SCIENCE

Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

(2013) Fernando Goñi et al.   Journal of Neuroinflammation

Pyroglutamate-Modified Amyloid-� Protein Demonstrates Similar Properties in an Alzheimer's Disease Familial Mutant Knock-In Mouse and Alzheimer's Disease Brain

(2013) Guoxin Wu et al.   Neurodegenerative Diseases

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

(2012) Eric Heuer et al.   CURRENT PHARMACEUTICAL DESIGN

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

Immunotherapy for Alzheimer disease—the challenge of adverse effects

(2012) Yu-Hui Liu et al.   Nature Reviews Neurology

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

Review: Experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology

(2012) D. C. Lee et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Evaluating functional antibodies in rhesus monkeys immunized with hepatitis B virus surface antigen vaccine with novel adjuvant formulations

(2011) Daniel C. Freed et al.   VACCINE

Marked enhancement of the immune response to BioThrax® (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers

(2011) Dianna Rynkiewicz et al.   VACCINE

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

(2009) Jörg Vollmer et al.   ADVANCED DRUG DELIVERY REVIEWS

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

(2009) Yukiko Doi et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunotherapy, Vascular Pathology, and Microhemorrhages in Transgenic Mice

(2009) Donna Wilcock et al.   CNS & Neurological Disorders-Drug Targets

CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

(2009) John D. Campbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

(2009) H. Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

(2009) Todd E Golde et al.   Alzheimers Research & Therapy

Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain

(2008) Susan L Stevens et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid  1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2008) K. L. Richard et al.   JOURNAL OF NEUROSCIENCE

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

(2008) Terrence Town et al.   NATURE MEDICINE