Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer’s Disease

Dimebon Ameliorates Amyloid-β Induced Impairments of Mitochondrial Form and Function

(2018) Schamim H. Eckert et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced VDAC1 Protects Against Alzheimer's Disease, Mitochondria, and Synaptic Deficiencies

(2018) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

A Cell Model for the Initial Phase of Sporadic Alzheimer's Disease

(2018) Carola Stockburger et al.   JOURNAL OF ALZHEIMERS DISEASE

Rice Bran Extract Compensates Mitochondrial Dysfunction in a Cellular Model of Early Alzheimer's Disease

(2018) Stephanie Hagl et al.   JOURNAL OF ALZHEIMERS DISEASE

Synergistic Exacerbation of Mitochondrial and Synaptic Dysfunction and Resultant Learning and Memory Deficit in a Mouse Model of Diabetic Alzheimer's Disease

(2018) Yongfu Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease

(2017) Qian Cai et al.   JOURNAL OF ALZHEIMERS DISEASE

Exogenous BDNF Increases Mitochondrial pCREB and Alleviates Neuronal Metabolic Defects Following Mechanical Injury in a MPTP-Dependent Way

(2017) Zhen Xu et al.   MOLECULAR NEUROBIOLOGY

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease

(2017) Walter E. Müller et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

(2017) Flaubert Tchantchou et al.   JOURNAL OF ALZHEIMERS DISEASE

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease

(2017) Renato X. Santos et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

(2017) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Dimebon (Latrepirdine) Enhances Mitochondrial Function and Protects Neuronal Cells from Death

(2017) Shouting Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

(2017) Jon Valla et al.   JOURNAL OF ALZHEIMERS DISEASE

EGb761 improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse

(2016) Wenbin Wan et al.   EXPERIMENTAL GERONTOLOGY

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

(2016) Susana Cardoso et al.   Expert Review of Neurotherapeutics

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

(2016) Michelle Perkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Cortical Amyloid Burden Differences Across Empirically-Derived Mild Cognitive Impairment Subtypes and Interaction with APOE ɛ4 Genotype

(2016) Katherine J. Bangen et al.   JOURNAL OF ALZHEIMERS DISEASE

Independent and Interactive Influences of theAPOEGenotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment

(2016) Eun Hyun Seo et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Alzheimer, mitochondria and gender

(2016) Amandine Grimm et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease

(2016) Lu Wang et al.   PLoS One

Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson’s disease

(2016) Md Zeeshan Rasheed et al.   PROTOPLASMA

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

(2016) Susana Cardoso et al.   Expert Review of Neurotherapeutics

Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function

(2016) Carola Stockburger et al.   NEURAL PLASTICITY

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

(2015) Amandine Grimm et al.   BIOGERONTOLOGY

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

(2015) Gerwyn Morris et al.   BMC Medicine

Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease

(2015) Xu Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

Novel Sites of Neuroprotective Action of Dimebon (Latrepirdine)

(2015) Aleksey Ustyugov et al.   MOLECULAR NEUROBIOLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Synapses, spines and kinases in mammalian learning and memory, and the impact of aging

(2015) Eddy A. van der Zee   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Procognitive Compounds Promote Neurite Outgrowth

(2015) Matthew Page et al.   PHARMACOLOGY

Efficacy ofGinkgo bilobaextract EGb 761®in dementia with behavioural and psychological symptoms: A systematic review

(2015) Armin von Gunten et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

(2014) David A. Drachman   Alzheimers & Dementia

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

(2014) Eric Karran et al.   ANNALS OF NEUROLOGY

Alzheimer disease therapeutics: Focus on the disease and not just plaques and tangles

(2014) Khalid Iqbal et al.   BIOCHEMICAL PHARMACOLOGY

Dimebon Attenuates the Aβ-Induced Mitochondrial Permeabilization

(2014) Elena Shevtsova et al.   Current Alzheimer Research

Effects of standardized extract of Ginkgo biloba leaves EGb761 on mitochondrial functions: mechanism(s) of action and dependence on the source of mitochondria and respiratory substrate

(2014) Giedre Baliutyte et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study

(2014) Clifford R Jack et al.   LANCET NEUROLOGY

Targeting the Prodromal Stage of Alzheimer’s Disease: Bioenergetic and Mitochondrial Opportunities

(2014) Charles C. Caldwell et al.   Neurotherapeutics

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

Protective effect and mechanism of Ginkgo biloba extract-EGb 761 on STZ-induced diabetic cardiomyopathy in rats

(2014) ArminderSingh Saini et al.   Pharmacognosy Magazine

EGb761 Provides a Protective Effect against Aβ1-42 Oligomer-Induced Cell Damage and Blood-Brain Barrier Disruption in an In Vitro bEnd.3 Endothelial Model

(2014) Wen-bin Wan et al.   PLoS One

The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)

(2014) Shannon Risacher   Frontiers in Aging Neuroscience

Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials

(2014) Serge Gauthier et al.   Clinical Interventions in Aging

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis

(2013) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

Improvement of mitochondrial function and dynamics by the metabolic enhancer piracetam

(2013) Carola Stockburger et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Key Role of Mitochondria in Alzheimer’s Disease Synaptic Dysfunction

(2013) Virve Cavallucci et al.   CURRENT PHARMACEUTICAL DESIGN

Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin

(2013) Rute A.P. Costa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis

(2013) YU FANG et al.   Experimental and Therapeutic Medicine

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

(2013) P R Bharadwaj et al.   Translational Psychiatry

Mitofusins and the mitochondrial permeability transition: the potential downside of mitochondrial fusion

(2012) Kyriakos N. Papanicolaou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

(2012) Jerome Piquereau et al.   CARDIOVASCULAR RESEARCH

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

(2012) Ewa Malatynska et al.   EXPERIMENTAL GERONTOLOGY

Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity

(2012) Walter E. Müller et al.   INTERNATIONAL PSYCHOGERIATRICS

From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer’s Disease

(2012) Kristina Leuner et al.   MOLECULAR NEUROBIOLOGY

Effects of Polyphenols on Brain Ageing and Alzheimer’s Disease: Focus on Mitochondria

(2012) Sebastian Schaffer et al.   MOLECULAR NEUROBIOLOGY

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

Impairments of Synaptic Plasticity in Aged Animals and in Animal Models of Alzheimer's Disease

(2012) Marta Balietti et al.   REJUVENATION RESEARCH

Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease

(2012) Wendou Yu et al.   NEURAL PLASTICITY

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys

(2011) Scott J Webster et al.   BRITISH JOURNAL OF PHARMACOLOGY

The therapeutic potential of mitochondrial channels in cancer, ischemia–reperfusion injury, and neurodegeneration

(2011) Pablo M. Peixoto et al.   MITOCHONDRION

VDAC, a multi-functional mitochondrial protein as a pharmacological target

(2011) Varda Shoshan-Barmatz et al.   MITOCHONDRION

Latrepirdine increases cerebral glucose utilization in aged mice as measured by [18F]-fluorodeoxyglucose positron emission tomography

(2011) M. Day et al.   NEUROSCIENCE

Spines, Plasticity, and Cognition in Alzheimer's Model Mice

(2011) Tara Spires-Jones et al.   NEURAL PLASTICITY

Mitochondria and Neuroplasticity

(2010) Aiwu Cheng et al.   ASN Neuro

The mitochondria permeability transition pore complex in the brain with interacting proteins – promising targets for protection in neurodegenerative diseases

(2010) Tamara Azarashvili et al.   BIOLOGICAL CHEMISTRY

The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by ß-amyloid peptide

(2010) C Kurz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of a Proneurogenic, Neuroprotective Chemical

(2010) Andrew A. Pieper et al.   CELL

Dimebolin in Dementia

(2010) Deepak Sachdeva et al.   CNS Neuroscience & Therapeutics

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

(2010) A. Y. Seo et al.   JOURNAL OF CELL SCIENCE

Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-D-aspartate Receptor Antagonism

(2010) M. Giorgetti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects

(2010) Walter E. Müller et al.   MOLECULAR NEUROBIOLOGY

Dimebon Inhibits Calcium-Induced Swelling of Rat Brain Mitochondria But Does Not Alter Calcium Retention or Cytochrome C Release

(2010) Kranthi Kumari Naga et al.   NEUROMOLECULAR MEDICINE

Ginkgo Biloba Extract Ameliorates Oxidative Phosphorylation Performance and Rescues Aβ-Induced Failure

(2010) Virginie Rhein et al.   PLoS One

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

(2010) Julie Vignisse et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Regulation and pharmacology of the mitochondrial permeability transition pore

(2009) D. B. Zorov et al.   CARDIOVASCULAR RESEARCH

Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

(2009) Toshio Hisatomi et al.   EXPERIMENTAL NEUROLOGY

Nootropic agents stimulate neurogenesis

(2009) Philippe Taupin   EXPERT OPINION ON THERAPEUTIC PATENTS

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Ultrastructure of the Mitochondrion and Its Bearing on Function and Bioenergetics

(2008) Giovanni Benard et al.   ANTIOXIDANTS & REDOX SIGNALING

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON