Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain

(2014) L. N. Sorensen et al.   JOURNAL OF IMMUNOLOGY

Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia

(2011) Bolanle M. Famakin et al.   BRAIN RESEARCH

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TLR2 Hypersensitivity of Astrocytes as Functional Consequence of Previous Inflammatory Episodes

(2011) A. Henn et al.   JOURNAL OF IMMUNOLOGY

MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection†

(2011) Shuliang Liu et al.   Journal of Neuroinflammation

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Toll-Like Receptor (TLR) 2 and TLR9 Expressed in Trigeminal Ganglia are Critical to Viral Control During Herpes Simplex Virus 1 Infection

(2010) Graciela Kunrath Lima et al.   AMERICAN JOURNAL OF PATHOLOGY

Roles of Toll-like receptor 2 (TLR2) and superantigens on adaptive immune responses during CNS staphylococcal infection

(2010) Debbie Vidlak et al.   BRAIN BEHAVIOR AND IMMUNITY

Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS?

(2010) Catherine E Downes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Localisation and trafficking of Toll-like receptors: an important mode of regulation

(2010) Anne F McGettrick et al.   CURRENT OPINION IN IMMUNOLOGY

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Active Immunization with Amyloid-  1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

(2010) P. Vollmar et al.   JOURNAL OF IMMUNOLOGY

New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

(2010) Rebecca C. Coll et al.   Journal of Innate Immunity

TLR2 activation inhibits embryonic neural progenitor cell proliferation

(2010) Eitan Okun et al.   JOURNAL OF NEUROCHEMISTRY

The Innate Immune Adaptor Molecule MyD88 Restricts West Nile Virus Replication and Spread in Neurons of the Central Nervous System

(2010) K. J. Szretter et al.   JOURNAL OF VIROLOGY

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Influence of Perineurial Cells and Toll-Like Receptors 2 and 9 on Herpes simplex Type 1 Entry to the Central Nervous System in Rat Encephalitis

(2010) Biborka Bereczky-Veress et al.   PLoS One

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

(2010) E. Okun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MyD88 Expression by CNS-Resident Cells is Pivotal for Eliciting Protective Immunity in Brain Abscesses

(2009) Sarita Garg et al.   ASN Neuro

Responses to Amyloids of Microbial and Host Origin Are Mediated through Toll-like Receptor 2

(2009) Çagla Tükel et al.   Cell Host & Microbe

Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation

(2009) Bart R Tambuyzer et al.   IMMUNOLOGY AND CELL BIOLOGY

MyD88-Deficient Mice Exhibit Decreased Parasite-Induced Immune Responses but Reduced Disease Severity in a Murine Model of Neurocysticercosis

(2009) B. B. Mishra et al.   INFECTION AND IMMUNITY

TLR Activation Induces TNF-  Production from Adult Neural Stem/Progenitor Cells

(2009) R. Covacu et al.   JOURNAL OF IMMUNOLOGY

IL-10 Mediates Resistance to Adoptive Transfer Experimental Autoimmune Encephalomyelitis in MyD88 −/− Mice

(2009) Shmuel J. Cohen et al.   JOURNAL OF IMMUNOLOGY

Microglial Activation by Citrobacter koseri Is Mediated by TLR4- and MyD88-Dependent Pathways

(2009) S. Liu et al.   JOURNAL OF IMMUNOLOGY

TLR2 Deficiency Leads to Increased Th17 Infiltrates in Experimental Brain Abscesses

(2009) J. R. Nichols et al.   JOURNAL OF IMMUNOLOGY

Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus

(2009) R. Naesens et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Role of Galectin-3/MAC-2 in the Activation of the Innate-Immune Function of Phagocytosis in Microglia in Injury and Disease

(2009) Shlomo Rotshenker   JOURNAL OF MOLECULAR NEUROSCIENCE

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

(2009) H. Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Changes in risk factors and preventive treatments by stroke subtypes over 20years: A population-based study

(2009) Yannick Béjot et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Tumour necrosis factor-α impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1

(2009) Aoife Keohane et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

(2009) Stefanie Frank et al.   NEUROSCIENCE LETTERS

SOCS1 and SOCS3 in the control of CNS immunity

(2009) Brandi J. Baker et al.   TRENDS IN IMMUNOLOGY

Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

(2008) Colm Cunningham et al.   BIOLOGICAL PSYCHIATRY

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

(2008) Monica Marta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Yaaautoimmune phenotypes are conferred by overexpression of TLR7

(2008) Anna‐Marie Fairhurst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens

(2008) Vinita S. Chauhan et al.   GLIA

CD14 Works with Toll‐Like Receptor 2 to Contribute to Recognition and Control ofListeria monocytogenesInfection

(2008) Laure Janot et al.   JOURNAL OF INFECTIOUS DISEASES

Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4

(2008) Matthias Klein et al.   JOURNAL OF INFECTIOUS DISEASES

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Expression and distribution of Toll-like receptors 11–13 in the brain during murine neurocysticercosis

(2008) Bibhuti B Mishra et al.   Journal of Neuroinflammation

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid  1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2008) K. L. Richard et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 3 Is a Negative Regulator of Embryonic Neural Progenitor Cell Proliferation

(2008) J. D. Lathia et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

(2008) S. Daffis et al.   JOURNAL OF VIROLOGY

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

(2008) Ulkan Kilic et al.   NEUROBIOLOGY OF DISEASE

Microglial clearance function in health and disease

(2008) I. Napoli et al.   NEUROSCIENCE

Herpesvirus tegument protein activates NF- B signaling through the TRAF6 adaptor protein

(2008) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central Nervous System Infections in the Intensive Care Unit

(2008) Benjamin Greenberg   SEMINARS IN NEUROLOGY

Toll-like receptors: roles in neuroprotection?

(2008) Uwe-Karsten Hanisch et al.   TRENDS IN NEUROSCIENCES

Both TLR2 and TLR4 Are Required for the Effective Immune Response in Staphylococcus aureus-Induced Experimental Murine Brain Abscess

(2007) Werner Stenzel et al.   AMERICAN JOURNAL OF PATHOLOGY

Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons

(2007) Cristian Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING

Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS

(2003) Nathalie Laflamme et al.   JOURNAL OF NEUROCHEMISTRY