Article
Pharmacology & Pharmacy
Chongjie Cheng, Xiaoshu Wang, Yinghua Jiang, Yadan Li, Zhengbu Liao, Wenlu Li, Zhanyang Yu, Michael J. Whalen, Josephine Lok, Aaron S. Dumont, Ning Liu, Xiaoying Wang
Summary: Microvascular failure is crucial in the pathological evolution after TBI. Annexin A2 has shown potential in protecting against cerebral permeability and angiogenesis impairment, suggesting it as a candidate for cerebrovascular therapy. In experiments, rA2 treatment improved BBB integrity, enhanced mRNA levels of pro-angiogenic factors, activated cellular signaling pathways, induced angiogenesis, and improved long-term neurological function after TBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yu-Xin Ding, Gao-Wa Eerduna, Si-Jin Duan, Ting Li, Rong-Xia Liu, Lei-Ming Zhang, Tian Wang, Feng-Hua Fu
Summary: The study demonstrates that escin improves neurological function in ICH mice by ameliorating systemic inflammation instead of directly targeting the brain, notably by inhibiting the IL-1 beta/RhoA/NF-kappa B signaling pathway in the blood-brain barrier. This suggests a potential therapeutic approach for brain injury post-ICH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Valentina Bonetto, Laura Pasetto, Ilaria Lisi, Marco Carbonara, Rosalia Zangari, Erica Ferrari, Veronica Punzi, Silvia Luotti, Nicola Bottino, Bruno Biagianti, Cristina Moglia, Giuseppe Fuda, Roberta Gualtierotti, Francesco Blasi, Ciro Canetta, Nicola Montano, Mauro Tettamanti, Giorgia Camera, Maria Grimoldi, Giulia Negro, Nicola Rifino, Andrea Calvo, Paolo Brambilla, Francesco Biroli, Alessandra Bandera, Alessandro Nobili, Nino Stocchetti, Maria Sessa, Elisa R. R. Zanier
Summary: This study found that COVID-19 patients have BBB disruption and neuronal damage, which may be associated with an increased risk of neurological complications. In the acute phase, ICUCovid patients had the highest levels of PPIA and IL-10, while NeuroCovid patients had the highest levels of MMP-9 in the acute phase with a severity dependency in the long-term. Furthermore, deceased patients had the highest levels of NFL and GFAP.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dhananjay Bhatane, Sharon Rose Pamshong, Santosh Sarnaik, A. Prabakaran, Amit Alexander
Summary: Neurological disorders pose an emerging threat to public health, and traditional therapy is unable to fully cure these disorders due to poor blood-brain barrier permeability. Scientists have focused on developing novel drug delivery carriers, such as mesoporous silica nanoparticles, to improve drug delivery to the brain. These nanoparticles have unique properties that make them suitable for delivering drugs to the brain and have been extensively studied for treating neurological disorders.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ashley R. Ricciardelli, Ariadna Robledo, Jason E. Fish, Peter T. Kan, Tajie H. Harris, Joshua D. Wythe
Summary: This paper discusses the role of the immune system in the development and progression of brain arteriovenous malformations (bAVMs) and the potential for targeting inflammation to prevent bAVM rupture and intracranial hemorrhage. Inflammation has been suggested as a contributor to lesion progression, and a dysfunctional endothelium may drive disease development and progression by altering the immune status of the brain.
Article
Neurosciences
Han Liu, Junchi He, Yue Wu, Yang Du, Yinghua Jiang, Chengzhi Chen, Zhanyang Yu, Jianjun Zhong, Zhigang Wang, Chongjie Cheng, Xiaochuan Sun, Zhijian Huang
Summary: The study showed that exogenous rANXA1 can improve BBB disruption and inflammatory response, leading to better functional outcomes following traumatic brain injury.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yabin Ji, Yiman Chen, Xixi Tan, Xiaowen Huang, Qiang Gao, Yinzhong Ma, Shilun Yang, Meifang Yin, Min Yu, Cheng Fang, Yu Wang, Zhu Shi, Junlei Chang
Summary: This study identified the key molecular signatures of brain endothelial reperfusion injury and revealed potential therapeutic targets for the treatment of brain microvascular injury after reperfusion therapy in ischemic stroke. The findings provide important insights into the mechanisms and potential treatments for brain microvascular injury after reperfusion therapy.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Anatomy & Morphology
Yating Ling, Murugan Ramalingam, Xiaorui Lv, Yu Zeng, Yun Qiu, Yu Si, Jose Luis Pedraz, Hae-Won Kim, Jiabo Hu
Summary: Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide, and its treatment has seen limited progress in recent years due to the challenges of drug delivery to the brain. However, nanomedicine using nanomaterials as drug carriers is emerging as a promising strategy for the treatment of TBI. This review article provides insights into the pathophysiology of TBI, current treatment options, and emerging nanomedicine strategies, offering a comprehensive overview of the state-of-the-art in treating TBI.
Review
Chemistry, Multidisciplinary
Abdul Waris, Asmat Ali, Atta Ullah Khan, Muhammad Asim, Doaa Zamel, Kinza Fatima, Abdur Raziq, Muhammad Ajmal Khan, Nazia Akbar, Abdul Baset, Mohammed A. S. Abourehab
Summary: Neurological disorders are a major global health concern and lack effective treatments. Nano-scale materials have shown promise in improving drug efficacy and bypassing the blood-brain barrier, and are widely used for the treatment and imaging studies of neurological disorders.
Review
Neurosciences
Yiran Wang, Shunyu Yu, Mengqian Li
Summary: Normal brain development, function, and aging depend on the unique characteristics of the cerebrovascular system. Cerebrovascular defects have irreversible effects on the brain and are implicated in neurological disorders, including autism spectrum disorder (ASD). The role of brain vasculature in ASD is poorly understood and underestimated, but recent findings suggest that ASD can be considered a neurovascular disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Medicine, Research & Experimental
Kritika Tyagi, Prachi Rai, Anuj Gautam, Harjeet Kaur, Sumeet Kapoor, Ashish Suttee, Pradeep Kumar Jaiswal, Akanksha Sharma, Gurpal Singh, Ravi Pratap Barnwal
Summary: The article summarizes the impact of the SARS-CoV-2 virus on brain function and the related diseases of the central nervous system. It has been found that the virus can enter the central nervous system through the blood-brain barrier, causing various illnesses including strokes and thrombosis. SARS-CoV-2 can also result in neurological symptoms and disorders, impair cognitive function, and lead to neurological diseases.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Pavel P. Tregub, Irada Ibrahimli, Anton S. Averchuk, Alla B. Salmina, Peter F. Litvitskiy, Zaripat Sh. Manasova, Inga A. Popova
Summary: In recent times, there has been a growing interest among researchers in understanding the functions of microRNAs and their role in the development of various diseases. This review analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying Alzheimer's disease, cerebral ischemia and reperfusion injury, and blood-brain barrier dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Patrick Bechinger, Lucas Serrano Sponton, Verena Gruetzner, Anna Musyanovych, Daniel Jussen, Harald Krenzlin, Daniela Eldahaby, Nicole Riede, Oliver Kempski, Florian Ringel, Beat Alessandri
Summary: Polymeric nanoparticles have the potential to deliver drugs across the blood-brain barrier in traumatic brain injury (TBI), but the impact of nanoparticle material and surfactant type on their distribution within organs and their ability to cross the BBB after TBI, as well as their potential inflammatory response, require further investigation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Chemistry, Physical
Avneet Kour, Himanshu Sekhar Panda, Imocha Rajkumar Singh, Ashwani Kumar, Jiban Jyoti Panda
Summary: Nanotherapeutics are gaining popularity for their unique properties compared to macro materials. Metal nanoparticles (MNPs) have emerged as important due to their distinct physicochemical and biological characteristics. Peptides have various important functions in the human body and have been approved as pharmaceuticals, with clinical trials underway. Combining MNPs with peptides has potential for successful targeting, diagnosis, and therapy of neurological pathologies.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Medicine, General & Internal
Han Wei, Xiaojun Xin, Jing Zhang, Qingya Xie, Muhammad Naveed, Kaiyan Chen, Pingxi Xiao
Summary: The meta-analysis of existing randomized controlled trials showed that supplementing with CoQ10 did not significantly improve statin-induced myopathy. Results indicated that the addition of CoQ10 did not have a significant impact on CK activity and muscle pain in patients receiving statin therapy.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Muhammed Lamin Sambou, Xiaoyu Zhao, Tongtong Hong, Muhammad Naveed, Alima Sambou, Fadoua El Hafa, TIl B. Basnet, Juncheng Dai
Summary: The study found that unhealthy sleep behaviors like insomnia, napping, daytime sleepiness, and difficulty getting up from bed are associated with an increased risk of shortened healthspan. Adherence to healthy sleep behavior is significant for extending healthspan.
SLEEP AND BREATHING
(2022)
Review
Medicine, Research & Experimental
Chang-Xing Li, Sobia Noreen, Li-Xue Zhang, Muhammad Saeed, Pei-Feng Wu, Muhammad Ijaz, Dong-Fang Dai, Irsah Maqbool, Asadullah Madni, Faizan Akram, Muhammad Naveed, Jian-Hua Li
Summary: This article summarizes the global outbreak of coronavirus disease, different strains of SARS-CoV-2, etiology, complexities in treatment, and the current status of vaccines for COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Manthar Ali Mallah, Changxing Li, Mukhtiar Ali Mallah, Sobia Noreen, Yang Liu, Muhammad Saeed, He Xi, Bilal Ahmed, Feifei Feng, Ali Asghar Mirjat, Wei Wang, Abdul Jabar, Muhammad Naveed, Jian-Hua Li, Qiao Zhang
Summary: Polycyclic aromatic hydrocarbons (PAHs) are chemical contaminants of environmental significance. PAH pollution mainly comes from anthropogenic sources and can pose a significant threat to human health. Long-term exposure to PAHs can lead to tumor development in multiple organs and increase the risk of lung cancer and cardiovascular diseases. Studies have shown a relationship between PAH exposure, oxidative stress, and atherosclerosis.
Review
Pharmacology & Pharmacy
Qin-Yuan Li, Mahzaib Munawar, Muhammad Saeed, Ji-Qiang Shen, Muhammad Sajjad Khan, Sobia Noreen, Mahmoud Alagawany, Muhammad Naveed, Asadullah Madni, Chang-Xing Li
Summary: Increasing health consciousness and knowledge about synthetic drug side effects have led to a growing interest in traditional medicines, especially herb-based medicines like Citrullus colocynthis. This herbaceous plant is rich in nutrients and bioactive compounds, offering various medicinal properties such as antioxidative, anti-inflammatory, and even pesticidal effects. Comprehensive research and analysis have shown the potential of C. colocynthis in treating disorders in both humans and animals, highlighting its positive impacts and potential risks on human health, particularly in veterinary and poultry fields.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Naveed, Lian-Di Li, Gang Sheng, Zi-Wei Du, Ya-Ping Zhou, Sun Nan, Ming-Yi Zhu, Jing Zhang, Qi-Gang Zhou
Summary: Agomelatine, a unique melatonin analog, has antidepressant properties and a large therapeutic index that improves clinical safety. It acts as an agonist on melatonin receptors (MT1 and MT2) and an antagonist on 5HT2C receptors, enabling the resynchronization of circadian rhythms and improving sleep architecture.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Muhammad Naveed, Changxing Li, Awais Ullah Ihsan, Muhammad Shumzaid, Asghar Ali Kamboh, Ali Asghar Mirjat, Muhammad Saeed, Mirza Muhammad Faran Ashraf Baig, Hafiz Muhammad Zubair, Sobia Noreen, Asadullah Madni, Xiaohui Zhou
Summary: The assessment and management of urologic chronic pelvic pain syndrome (UCPPS) is controversial due to the lack of reliable tools for evaluating symptoms and quality of life impact. The etiology is multifactorial, and treatment options are uncertain. The immune system plays an important role in the disease. The UPOINT system can guide treatment and improve symptoms.
Article
Environmental Sciences
Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Muhammad Naveed, Yang Liu, Sobia Noreen, He Xi, Wei Wang, Feifei Feng, Qiao Zhang
Summary: This study aimed to investigate the association between urinary PAHs and cardiovascular diseases. The results showed a positive correlation between urinary PAHs and the prevalence of coronary heart disease, angina, heart attack, and stroke.
ENVIRONMENTAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Sobia Noreen, Arslan Maqbool, Irsah Maqbool, Afifa Shafique, Muhammad Muzamil Khan, Yasmeen Junejo, Bilal Ahmed, Maryam Anwar, Asma Majeed, Muhammad Abbas, Muhammad Naveed, Asadullah Madni
Summary: Nanotechnology is the emerging field that focuses on controlling material configuration at a reduced scale, and multifunctional mesoporous silica nanoparticles (MSNPs) have been shown to have great potential in tumor treatment and imaging. Functionalized mesoporous silica materials have rapidly advanced in imaging and therapeutic applications.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Rehabilitation
Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed
Summary: Obesity is a severe health concern that is associated with heart failure and cardiovascular disease. It is caused by a metabolic imbalance where more calories are consumed than burnt. Obesity has adverse impacts on the cardiovascular system, including inflammation, atherosclerosis, and high blood pressure. It is also a known risk factor for various diseases.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Muhammad Safdar, Mehmet Ozaslan, Rebaz M. Mustafa, Shukur W. Smail, Samiha S. Khan, Muhammad Sajjad Khan, Muhammad Asad Akhtar, Hafiz Khawar Ali, Umair Younas, Muhammad Saeed, Faisal Siddique, Muhammad Naveed, SaifUr Rehman
Summary: This study explores the association between increased susceptibility and severity in hypertensive COVID-19 patients. The findings suggest that certain SNPs in the ACE2 gene may contribute to the severity of COVID-19 in individuals with hypertension.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Muhammed Lamin Sambou, Juncheng Dai, Xiaoyu Zhao, Tongtong Hong, Til Bahadur Basnet, Gifty Marley, Alima Sambou, El Hafa Fadoua, Muhammad Naveed
Summary: The study identified 8 significant determinants of VCT service uptake among adults in sub-Saharan Africa (SSA), including lower physical access, older age, higher education level, high knowledge of HIV and VCT awareness, unprotected sexual practices, discussion on HIV among partners and others, other STIs, and divorced/separated status. The findings suggest that HIV interventions and policy initiatives should be tailored to these determinants in order to increase VCT service uptake in SSA.
PUBLIC HEALTH REVIEWS
(2022)
Article
Engineering, Biomedical
Waqas Nawaz, Muhammad Naveed, Jing Zhang, Sobia Noreen, Muhammad Saeed, Kiganda Raymond Sembatya, Awais Ullah Ihsan, Imran Shair Mohammad, Gang Wang, Xiaohui Zhou
Summary: This study evaluates the feasibility and cardio-protective effects of a biocompatible silicon-built restraint device (ASD) in a rat model of heart failure. The results show that the ASD device is safe and effective in attenuating ventricular remodeling and improving heart function. Furthermore, ASD treatment reduces myocardial fibrosis, indicating significant therapeutic effects.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Review
Environmental Sciences
Eno E. Essien, Kassim Said Abasse, Andre Cote, Kassim Said Mohamed, Mirza Muhammad Faran Ashraf Baig, Murad Habib, Muhammad Naveed, Xiaojin Yu, Weihua Xie, Sun Jinfang, Muhammad Abbas
Summary: This study found an association between nitrate intake from drinking water and a specific type of cancer in humans. Controlling nitrate concentrations in drinking water is crucial for preventing pollution.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2022)
