The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes?

Development and validation of a hypoxia-related gene pair signature to predict overall survival in head and neck squamous cell carcinoma

(2021) Zhao Ding et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Hypoxia and the phenomenon of immune exclusion

(2021) Violena Pietrobon et al.   Journal of Translational Medicine

Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies

(2021) Raefa Abou Khouzam et al.   Frontiers in Immunology

Hypoxia Molecular Characterization in Hepatocellular Carcinoma Identifies One Risk Signature and Two Nomograms for Clinical Management

(2021) Zaoqu Liu et al.   Journal of Oncology

A novel hypoxia gene signature indicates prognosis and immune microenvironments characters in patients with hepatocellular carcinoma

(2021) Qiangnu Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors

(2021) Gregg L. Semenza   PHYSIOLOGY

Effects of Hypoxia in Intestinal Tumors on Immune Cell Behavior in the Tumor Microenvironment

(2021) Luping Zhang et al.   Frontiers in Immunology

An Effective Hypoxia-Related Long Non-Coding RNAs Assessment Model for Prognosis of Clear Cell Renal Carcinoma

(2021) Han Zhang et al.   Frontiers in Oncology

Identification and validation of a hypoxia-related prognostic and immune microenvironment signature in bladder cancer

(2021) Xianchao Sun et al.   Cancer Cell International

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

(2021) Stefan C. Dentro et al.   CELL

A 4-gene-based hypoxia signature is associated with tumor immune microenvironment and predicts the prognosis of pancreatic cancer patients

(2021) Jianfeng Ding et al.   World Journal of Surgical Oncology

FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer

(2021) Yun Huang et al.   Nature Communications

A four-hypoxia-genes-based prognostic signature for oral squamous cell carcinoma

(2021) Chenguang Zhao et al.   BMC Oral Health

Highly Multiplexed Phenotyping of Immunoregulatory Proteins in the Tumor Microenvironment by CODEX Tissue Imaging

(2021) Darci Phillips et al.   Frontiers in Immunology

An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment

(2021) Raefa Abou Khouzam et al.   Frontiers in Immunology

Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways

(2021) Seon Ah Lim et al.   Cancers

Beyond Tumor Mutation Burden: Tumor Neoantigen Burden as a Biomarker for Immunotherapy and Other Types of Therapy

(2021) Peipei Wang et al.   Frontiers in Oncology

Development and Validation of a Hypoxia-Associated Prognostic Signature Related to Osteosarcoma Metastasis and Immune Infiltration

(2021) Yucheng Fu et al.   Frontiers in Cell and Developmental Biology

Tumor Hypoxia Drives Genomic Instability

(2021) Ming Tang et al.   Frontiers in Cell and Developmental Biology

Hypoxia Constructing the Prognostic Model of Colorectal Adenocarcinoma and Related to the Immune Microenvironment

(2021) Yuanyuan Zhang et al.   Frontiers in Cell and Developmental Biology

Identification of a Hypoxia-Related Signature for Predicting Prognosis and the Immune Microenvironment in Bladder Cancer

(2021) Minxiao Jiang et al.   Frontiers in Molecular Biosciences

Metabolic reprogramming due to hypoxia in pancreatic cancer: Implications for tumor formation, immunity, and more

(2021) Xiaodong Hao et al.   BIOMEDICINE & PHARMACOTHERAPY

The state of CD44 activation in cancer progression and therapeutic targeting

(2021) Qian Guo et al.   FEBS Journal

Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy

(2021) Sophie Groux-Degroote et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer

(2021) Andreia Peixoto et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

(2021) Samuel B Bader et al.   NUCLEIC ACIDS RESEARCH

Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy

(2021) Audrey Lequeux et al.   ONCOGENE

Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels

(2021) Marie-Anne Goyette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function

(2021) Sam Sheppard et al.   Cell Reports

A Hypoxia Gene-Based Signature to Predict the Survival and Affect the Tumor Immune Microenvironment of Osteosarcoma in Children

(2021) Feng Jiang et al.   Journal of Immunology Research

A Robust Hypoxia Risk Score Predicts the Clinical Outcomes and Tumor Microenvironment Immune Characters in Bladder Cancer

(2021) Zhi Liu et al.   Frontiers in Immunology

Screening and Validation of the Hypoxia-Related Signature of Evaluating Tumor Immune Microenvironment and Predicting Prognosis in Gastric Cancer

(2021) Jun-Peng Pei et al.   Frontiers in Immunology

Multi-Omics Profiling Identifies Risk Hypoxia-Related Signatures for Ovarian Cancer Prognosis

(2021) Xingyu Chen et al.   Frontiers in Immunology

Development and Validation of a Hypoxia-Related Signature for Predicting Survival Outcomes in Patients With Bladder Cancer

(2021) Facai Zhang et al.   Frontiers in Genetics

Identifying Hypoxia Characteristics to Stratify Prognosis and Assess the Tumor Immune Microenvironment in Renal Cell Carcinoma

(2021) Zhenan Zhang et al.   Frontiers in Genetics

A Hypoxia Signature for Predicting Prognosis and Tumor Immune Microenvironment in Adrenocortical Carcinoma

(2021) Xi Chen et al.   Journal of Oncology

Identification of a Four Hypoxia-Associated Long Non-Coding RNA Signature and Establishment of a Nomogram Predicting Prognosis of Clear Cell Renal Cell Carcinoma

(2021) Hualin Chen et al.   Frontiers in Oncology

Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients

(2021) Yu-feng Chen et al.   Frontiers in Medicine

Targeted delivery of doxorubicin through CD44 aptamer to cancer cells

(2021) Jagadish Natesh et al.   Therapeutic Delivery

Development and validation of a prognostic classifier based on HIF-1 signaling for hepatocellular carcinoma

(2020) Feiwen Deng et al.   Aging-US

Tumor Immunology and Tumor Evolution: Intertwined Histories

(2020) Jérôme Galon et al.   IMMUNITY

Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy

(2020) Raefa Abou Khouzam et al.   SEMINARS IN CANCER BIOLOGY

Divergent mutational processes distinguish hypoxic and normoxic tumours

(2020) Vinayak Bhandari et al.   Nature Communications

ImmuCellAI: A Unique Method for Comprehensive T‐Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy

(2020) Ya‐Ru Miao et al.   Advanced Science

anlotinib alters tumor immune microenvironment by downregulating PD-L1 expression on vascular endothelial cells

(2020) Shaochuan Liu et al.   Cell Death & Disease

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

(2020) Maira Di Tano et al.   Nature Communications

Overcoming hypoxia-induced functional suppression of NK cells

(2020) Kristen Solocinski et al.   Journal for ImmunoTherapy of Cancer

Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer

(2020) Yoshihiro Morita et al.   Cancers

Hypoxia-Driven Immune Escape in the Tumor Microenvironment

(2020) Alyssa Vito et al.   Cells

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

(2020) Shing Yau Tam et al.   Frontiers in Oncology

Characterization of Hypoxia Signature to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Glioma Groups

(2020) Wanzun Lin et al.   Frontiers in Oncology

Immunomodulatory Roles of VEGF Pathway Inhibitors in Renal Cell Carcinoma

(2020) Laure Hirsch et al.   DRUGS

Error‐prone DNA repair pathways as determinants of immunotherapy activity: an emerging scenario for cancer treatment

(2020) Daniele Caracciolo et al.   INTERNATIONAL JOURNAL OF CANCER

FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

(2020) Jae Hong Im et al.   Nature Communications

Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways

(2020) Rui Teng et al.   Journal of Immunology Research

Identification of a Hypoxia-Associated Signature for Lung Adenocarcinoma

(2020) Zhuomao Mo et al.   Frontiers in Genetics

A hypoxia-related signature for clinically predicting diagnosis, prognosis and immune microenvironment of hepatocellular carcinoma patients

(2020) Baohui Zhang et al.   Journal of Translational Medicine

Ectonucleotidase CD73 and CD39 expression in non-small cell lung cancer relates to hypoxia and immunosuppressive pathways

(2020) Alexandra Giatromanolaki et al.   LIFE SCIENCES

M2‑TAM subsets altered by lactic acid promote T‑cell apoptosis through the PD‑L1/PD‑1 pathway

(2020) Tao Shan et al.   ONCOLOGY REPORTS

Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

(2020) Mariana C. Silva et al.   Cancer Immunology Research

Targeting Hypoxia-A2A Adenosinergic Immunosuppression of Antitumor T Cells During Cancer Immunotherapy

(2020) Joseph M. Steingold et al.   Frontiers in Immunology

DNA Repair and Signaling in Immune-Related Cancer Therapy

(2020) Sangeeta Kakoti et al.   Frontiers in Molecular Biosciences

The role of hypoxia‐inducible factor 1 in tumor immune evasion

(2020) Li You et al.   MEDICINAL RESEARCH REVIEWS

Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2

(2020) Robert R. Stickels et al.   NATURE BIOTECHNOLOGY

Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

(2020) Esha Madan et al.   TRENDS IN CELL BIOLOGY

Hypoxia-associated alternative splicing signature in lung adenocarcinoma

(2020) Zhanyu Xu et al.   Epigenomics

Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer

(2020) Lina Qi et al.   Frontiers in Oncology

Hypoxia-Associated Prognostic Markers and Competing Endogenous RNA Co-Expression Networks in Breast Cancer

(2020) Peng-Ju Gong et al.   Frontiers in Oncology

Stem cell quiescence and its clinical relevance

(2020) Meng Luo et al.   World Journal of Stem Cells

Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis

(2019) G. Comito et al.   ONCOGENE

T cell stemness and dysfunction in tumors are triggered by a common mechanism

(2019) Suman Kumar Vodnala et al.   SCIENCE

The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

(2019) Vishal Das et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

(2019) Audrey LEQUEUX et al.   CANCER LETTERS

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

(2019) Sung Hoon Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational approaches for characterizing the tumor immune microenvironment

(2019) Candace C. Liu et al.   IMMUNOLOGY

Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells

(2019) Denise Dorvignit et al.   Scientific Reports

The combined effect of FGFR inhibition and PD-1 blockade promotes tumor-intrinsic induction of antitumor immunity

(2019) Sangeetha Palakurthi et al.   Cancer Immunology Research

Local Administration of Caloric Restriction Mimetics to Promote the Immune Control of Lung Metastases

(2019) Valentino Le Noci et al.   Journal of Immunology Research

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Endothelial-to-Mesenchymal Transition (EndoMT): Roles in Tumorigenesis, Metastatic Extravasation and Therapy Resistance

(2019) Valentin Platel et al.   Journal of Oncology

AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity

(2019) Stéphane Terry et al.   Cancer Immunology Research

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

(2019) Muhammad Zaeem Noman et al.   Cells

Comprehensive Benchmarking and Integration of Tumor Microenvironment Cell Estimation Methods

(2019) Alejandro Jiménez-Sánchez et al.   CANCER RESEARCH

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma

(2019) Soumya R. Mohapatra et al.   Frontiers in Immunology

Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute

(2018) Paula A. Bousquet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

(2018) Debangshu Samanta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Computational deconvolution of transcriptomics data from mixed cell populations

(2018) Francisco Avila Cobos et al.   BIOINFORMATICS

Quantifying tumor-infiltrating immune cells from transcriptomics data

(2018) Francesca Finotello et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Caloric restriction counteracts chemotherapy-induced inflammation and increases response to therapy in a triple negative breast cancer model

(2018) Brittany A. Simone et al.   CELL CYCLE

Challenges to DNA replication in hypoxic conditions

(2018) Natalie Ng et al.   FEBS Journal

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Determinants and clinical implications of chromosomal instability in cancer

(2018) Laurent Sansregret et al.   Nature Reviews Clinical Oncology

Chemotherapy induces enrichment of CD47+/CD73+/PDL1+immune evasive triple-negative breast cancer cells

(2018) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma

(2018) Jing Zhang et al.   SCIENCE

Cancer stem cells: regulation programs, immunological properties and immunotherapy

(2018) Dingxiao Zhang et al.   SEMINARS IN CANCER BIOLOGY

GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy

(2018) Mayrel Labrada et al.   SEMINARS IN ONCOLOGY

The role of hypoxia in shaping the recruitment of proangiogenic and immunosuppressive cells in the tumor microenvironment

(2018) Salem Chouaib et al.   Wspolczesna Onkologia-Contemporary Oncology

ROLE OF GLYCOSYLATION IN HYPOXIA-DRIVEN CELL MIGRATION AND INVASION

(2018) Cecilia Arriagada et al.   Cell Adhesion & Migration

Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells

(2018) Xiang Song et al.   Oncotarget

CD4 T cell autophagy is integral to memory maintenance

(2018) Diane Murera et al.   Scientific Reports

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

(2018) Muhammad Zaeem Noman et al.   OncoImmunology

Unraveling the Role of Angiogenesis in Cancer Ecosystems

(2018) Iratxe Zuazo-Gaztelu et al.   Frontiers in Oncology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

(2018) Brian W. Labadie et al.   CLINICAL CANCER RESEARCH

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

(2018) Priyamvada Jayaprakash et al.   JOURNAL OF CLINICAL INVESTIGATION

Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases

(2018) Francesco Vallania et al.   Nature Communications

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

(2018) Monica Parodi et al.   Frontiers in Immunology

Glycans as Key Checkpoints of T Cell Activity and Function

(2018) Márcia S. Pereira et al.   Frontiers in Immunology

Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells

(2017) Oriana Lo Re et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies

(2017) Marie Schoumacher et al.   Current Oncology Reports

Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas

(2017) Yoshihiro Morita et al.   Oncology Letters

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

(2017) Ewelina Krzywinska et al.   Nature Communications

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

(2017) Julien Faget et al.   Cell Reports

Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function

(2017) Yael Gropper et al.   Cell Reports

Mind the Gaps in Tumor Immunity: Impact of Connexin-Mediated Intercellular Connections

(2017) María Alejandra Gleisner et al.   Frontiers in Immunology

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

(2017) Stéphane Terry et al.   OncoImmunology

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Key roles of autophagy in regulating T-cell function

(2016) Yair Botbol et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer

(2016) YAO CUI et al.   ONCOLOGY REPORTS

Dendritic Cells and Cancer Immunity

(2016) Alycia Gardner et al.   TRENDS IN IMMUNOLOGY

Autophagy-associated immune responses and cancer immunotherapy

(2016) Hongming Pan et al.   Oncotarget

Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension

(2016) Andreia Peixoto et al.   Oncotarget

VEGF Neutralization Plus CTLA-4 Blockade Alters Soluble and Cellular Factors Associated with Enhancing Lymphocyte Infiltration and Humoral Recognition in Melanoma

(2016) X. Wu et al.   Cancer Immunology Research

Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers

(2016) Alexandre Rouette et al.   Scientific Reports

Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy

(2015) Robert D. Leone et al.   CANCER CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment

(2015) Susan E. Scanlon et al.   DNA REPAIR

The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

(2015) Andrés Tittarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors

(2015) Thibault Voron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Interleukin-8: A potent promoter of angiogenesis in gastric cancer

(2015) JUN SHI et al.   Oncology Letters

PDGF upregulates CLEC-2 to induce T regulatory cells

(2015) Sudhanshu Agrawal et al.   Oncotarget

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Axl as a mediator of cellular growth and survival

(2015) Haley Axelrod et al.   Oncotarget

Autophagy-mediated regulation of macrophages and its applications for cancer

(2014) Peiwen Chen et al.   Autophagy

Mechanisms of Hypoxia-Mediated Immune Escape in Cancer

(2014) I. B. Barsoum et al.   CANCER RESEARCH

The generation of neutrophils in the bone marrow is controlled by autophagy

(2014) S Rožman et al.   CELL DEATH AND DIFFERENTIATION

Effects of Treg cells and IDO on human epithelial ovarian cancer cells under hypoxic conditions

(2014) JUN LIU et al.   Molecular Medicine Reports

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

Autophagy is essential for effector CD8+ T cell survival and memory formation

(2014) Xiaojin Xu et al.   NATURE IMMUNOLOGY

Interferons and Their Stimulated Genes in the Tumor Microenvironment

(2014) HyeonJoo Cheon et al.   SEMINARS IN ONCOLOGY

Autophagic degradation of GZMB/granzyme B

(2013) Elodie Viry et al.   Autophagy

Wnt/β-catenin signaling enhances hypoxia-induced epithelial–mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling

(2013) Qi Zhang et al.   CARCINOGENESIS

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Targeting the PDGF signaling pathway in tumor treatment

(2013) Carl-Henrik Heldin   Cell Communication and Signaling

Targeting the HIF pathway in inflammation and immunity

(2013) Carsten C Scholz et al.   CURRENT OPINION IN PHARMACOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Cutting Edge: Hypoxia-Induced Nanog Favors the Intratumoral Infiltration of Regulatory T Cells and Macrophages via Direct Regulation of TGF- 1

(2013) M. Hasmim et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Regulation of IDO Activity by Oxygen Supply: Inhibitory Effects on Antimicrobial and Immunoregulatory Functions

(2013) Silvia K. Schmidt et al.   PLoS One

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

(2013) J. Baginska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inferring tumour purity and stromal and immune cell admixture from expression data

(2013) Kosuke Yoshihara et al.   Nature Communications

Hypoxia-induced autophagy

(2012) Muhammad Zaeem Noman et al.   Autophagy

Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells

(2012) M. Z. Noman et al.   CANCER RESEARCH

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Associated Aberrant Protein O-Glycosylation Can Modify Antigen Processing and Immune Response

(2012) Caroline B. Madsen et al.   PLoS One

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

Beclin1/PI3K-Mediated Autophagy Prevents Hypoxia-Induced Apoptosis in EAhy926 Cell Line

(2011) Ruiguang Zhang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

(2011) M. Z. Noman et al.   CANCER RESEARCH

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

(2011) X.-H. Ma et al.   CLINICAL CANCER RESEARCH

Beclin-1 and LC3A expression in cutaneous malignant melanomas

(2011) Efthimios Sivridis et al.   MELANOMA RESEARCH

Multiscale Modelling of Vascular Tumour Growth in 3D: The Roles of Domain Size and Boundary Conditions

(2011) Holger Perfahl et al.   PLoS One

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential

(2011) Jeffery J. Auletta et al.   Stem Cells International

Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma

(2010) Xiang-Bo Wan et al.   Autophagy

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia

(2010) M I Koukourakis et al.   BRITISH JOURNAL OF CANCER

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Roles of hypoxia-inducible factor-1α (HIF-1α) versus HIF-2α in the survival of hepatocellular tumor spheroids

(2010) Heidi Menrad et al.   HEPATOLOGY

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia☆

(2010) Xiao-Wen Liu et al.   PHARMACOLOGICAL RESEARCH

VEGFR2 is selectively expressed by FOXP3high CD4+ Treg

(2009) Hiroyuki Suzuki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

(2009) Sandra J.M. Healy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Cooperative Induction of Hypoxia-Inducible Factor-1  and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis

(2009) M. Z. Noman et al.   JOURNAL OF IMMUNOLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

Vascular endothelium in cancer

(2008) Leonid L. Nikitenko   CELL AND TISSUE RESEARCH

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Fibroblast growth factor regulation of neovascularization

(2008) Masahiro Murakami et al.   CURRENT OPINION IN HEMATOLOGY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia induces a hedgehog response mediated by HIF-1α

(2008) Maarten F. Bijlsma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA