Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction in T Cell Development, Differentiation and Function

(2020) Muaz Rushdi et al.   Cells

p53’s Extended Reach: The Mutant p53 Secretome

(2020) Evangelos Pavlakis et al.   Biomolecules

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

(2020) Tomoya Muto et al.   NATURE IMMUNOLOGY

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A lineage-tracing tool to map the fate of hypoxic tumour cells

(2020) Jenny A. F. Vermeer et al.   Disease Models & Mechanisms

Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis

(2019) Zhijun Liu et al.   JOURNAL OF CELL SCIENCE

Cell competition during reprogramming gives rise to dominant clones

(2019) Nika Shakiba et al.   SCIENCE

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

(2019) John D. Martin et al.   Annual Review of Physiology

Stem cell competition orchestrates skin homeostasis and ageing

(2019) Nan Liu et al.   NATURE

Distinct modes of cell competition shape mammalian tissue morphogenesis

(2019) Stephanie J. Ellis et al.   NATURE

Transcriptional versus metabolic control of cell fitness during cell competition

(2019) Katerina Lawlor et al.   SEMINARS IN CANCER BIOLOGY

The Role of the Thymus in the Immune Response

(2019) Puspa Thapa et al.   Thoracic Surgery Clinics

Flower isoforms promote competitive growth in cancer

(2019) Esha Madan et al.   NATURE

Competition for nutrients and its role in controlling immune responses

(2019) Nidhi Kedia-Mehta et al.   Nature Communications

Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro

(2019) Larry L. Luchsinger et al.   Cell Stem Cell

HIF-transcribed p53 chaperones HIF-1α

(2019) Esha Madan et al.   NUCLEIC ACIDS RESEARCH

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

(2019) Iván M. Moya et al.   SCIENCE

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury

(2019) Jiann-Jyh Lai et al.   IMMUNITY

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

(2018) Hannah M. Knochelmann et al.   Cellular & Molecular Immunology

Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

(2018) Shizue Ohsawa et al.   DEVELOPMENTAL CELL

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

(2018) Sarah Bowling et al.   Nature Communications

Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

(2018) Kasumi Murai et al.   Cell Stem Cell

Autophagy Promotes Tumor-like Stem Cell Niche Occupancy

(2018) Shaowei Zhao et al.   CURRENT BIOLOGY

Cell competition in development: information from flies and vertebrates

(2018) Esha Madan et al.   CURRENT OPINION IN CELL BIOLOGY

Emerging mechanisms of asymmetric stem cell division

(2018) Zsolt G. Venkei et al.   JOURNAL OF CELL BIOLOGY

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress

(2018) Xiaodong Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

(2018) Joanne I. Hsu et al.   Cell Stem Cell

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

c-Myc-Dependent Cell Competition in Human Cancer Cells

(2017) Manish S. Patel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

(2017) Qi Zhang et al.   Molecular Cancer

Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status

(2017) Iwo Kucinski et al.   Nature Communications

Hypoxia activates Wnt/β-catenin signaling by regulating the expression of BCL9 in human hepatocellular carcinoma

(2017) Wei Xu et al.   Scientific Reports

JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins

(2017) Nomeda Girnius et al.   Cell Reports

Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer

(2017) David Basanta et al.   Cold Spring Harbor Perspectives in Medicine

MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad

(2017) Simone Di Giacomo et al.   Genes

Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity

(2017) Simone Di Giacomo et al.   Scientific Reports

The hypoxic microenvironment: A determinant of cancer stem cell evolution

(2016) Amancio Carnero et al.   BIOESSAYS

In vitro models of cancer stem cells and clinical applications

(2016) Sara S. Franco et al.   BMC CANCER

The Basis of Oncoimmunology

(2016) A. Karolina Palucka et al.   CELL

Cell Competition Drives the Formation of Metastatic Tumors in a Drosophila Model of Epithelial Tumor Formation

(2016) Teresa Eichenlaub et al.   CURRENT BIOLOGY

Cancer stem cells: A product of clonal evolution?

(2016) Gustav van Niekerk et al.   INTERNATIONAL JOURNAL OF CANCER

The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications

(2016) Ling Zhang et al.   LEUKEMIA & LYMPHOMA

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer

(2016) Marisa M. Merino et al.   TRENDS IN CELL BIOLOGY

Mechanical cell competition kills cells via induction of lethal p53 levels

(2016) Laura Wagstaff et al.   Nature Communications

c-Myc is regulated by HIF-2α in chronic hypoxia and influences sensitivity to 5-FU in colon cancer

(2016) Liangjing Wang et al.   Oncotarget

Regulation of Cellular Metabolism and Hypoxia by p53

(2016) Timothy J. Humpton et al.   Cold Spring Harbor Perspectives in Medicine

Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion

(2016) Hiroyuki Mori et al.   Scientific Reports

MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status

(2016) Takanori Chiba et al.   Scientific Reports

Cell Competition During Growth and Regeneration

(2015) Rajan Gogna et al.   Annual Review of Genetics

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

EDAC: Epithelial defence against cancer--cell competition between normal and transformed epithelial cells in mammals

(2015) M. Kajita et al.   JOURNAL OF BIOCHEMISTRY

Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc

(2015) H. Mamada et al.   JOURNAL OF CELL SCIENCE

Parent stem cells can serve as niches for their daughter cells

(2015) Ana Pardo-Saganta et al.   NATURE

Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development

(2015) Irving L. Weissman   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

(2015) Somayeh Jamali et al.   Scientific Reports

Cancer stem cell plasticity and tumor hierarchy

(2015) Marina Carla Cabrera   World Journal of Stem Cells

Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance

(2015) Daniel Verduzco et al.   PLoS One

Competition between human cells by entosis

(2014) Qiang Sun et al.   CELL RESEARCH

Cell competition is a tumour suppressor mechanism in the thymus

(2014) Vera C. Martins et al.   NATURE

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

(2013) Qing Li et al.   NATURE

Loss of Scribble causes cell competition in mammalian cells

(2012) M. Norman et al.   JOURNAL OF CELL SCIENCE

p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways

(2010) Y. Buganim et al.   CANCER RESEARCH

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Involvement of Lgl and Mahjong/VprBP in Cell Competition

(2010) Yoichiro Tamori et al.   PLOS BIOLOGY

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells

(2009) M. Kajita et al.   JOURNAL OF CELL SCIENCE

Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression

(2009) Ulrike Maegdefrau et al.   JOURNAL OF PATHOLOGY