Stem cell quiescence and its clinical relevance

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

(2020) Raymond Liang et al.   Cell Stem Cell

The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission

(2020) Sandrine Jeanpierre et al.   HAEMATOLOGICA

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

(2020) Federica Francescangeli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential

(2020) Marta Derecka et al.   NATURE IMMUNOLOGY

Neuropeptide Y is involved in the regulation of quiescence of hematopoietic stem cells

(2020) Baris Ulum et al.   NEUROPEPTIDES

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

(2020) Yue Sheng et al.   Nature Communications

Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway

(2020) Guodong Tie et al.   Scientific Reports

The Role of Cancer Stem Cells in Radiation Resistance

(2020) Christoph Reinhold Arnold et al.   Frontiers in Oncology

p57 is a master regulator of human adipose derived stem cell quiescence and senescence

(2020) Lian Wang et al.   Stem Cell Research

ZEB1 protects skeletal muscle from damage and is required for its regeneration

(2019) Laura Siles et al.   Nature Communications

Exosomes from differentially activated macrophages influence dormancy or resurgence of breast cancer cells within bone marrow stroma

(2019) Nykia D. Walker et al.   Cell Death & Disease

Haematopoietic stem cell activity and interactions with the niche

(2019) Sandra Pinho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells

(2019) Marius Bill et al.   LEUKEMIA

A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

(2019) Etienne C.E. Wang et al.   Cell Stem Cell

Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells

(2019) Puneet Agarwal et al.   Cell Stem Cell

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics

(2019) Fang Ni et al.   Cell Stem Cell

Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence

(2019) Saloni Sinha et al.   BLOOD

SET domain-containing protein 4 epigenetically controls breast cancer stem cell quiescence

(2019) Sen Ye et al.   CANCER RESEARCH

Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis

(2019) Yang Su et al.   CELL DEATH AND DIFFERENTIATION

Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia

(2019) Huafeng Wang et al.   LEUKEMIA

Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche

(2019) Tianyuan Hu et al.   Stem Cell Reports

CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners

(2019) Liang He et al.   Stem Cell Reports

Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells

(2019) Susan Eliazer et al.   Cell Stem Cell

Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus

(2019) Runrui Zhang et al.   Cell Reports

Fbxw7 and Skp2 Regulate Stem Cell Switch between Quiescence and Mitotic Division in Lung Adenocarcinoma

(2019) Wenzhu Zhang et al.   Biomed Research International

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Long non-coding RNA GAS5 acts as proliferation “brakes” in CD133+ cells responsible for tumor recurrence

(2019) Nikita S. Sharma et al.   Oncogenesis

Breast Cancer Stem Cells as Drivers of Tumor Chemoresistance, Dormancy and Relapse: New Challenges and Therapeutic Opportunities

(2019) De Angelis et al.   Cancers

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia

(2019) Chi Huu Nguyen et al.   Cell Death & Disease

Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma

(2019) Li Sun et al.   Cancer Research and Treatment

Laminin-521 promotes quiescence in isolated stellate cells from rat liver

(2018) Friederike Rohn et al.   BIOMATERIALS

NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling

(2018) Pablo R. Freire et al.   BLOOD

SRC-3 is involved in maintaining hematopoietic stem cell quiescence by regulation of mitochondrial metabolism in mice

(2018) Mengjia Hu et al.   BLOOD

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

(2018) Chao Zhang et al.   CELL RESEARCH

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

MicroRNA

(2018) Thomas X. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling

(2018) Linjia Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia

(2018) Bin Zhang et al.   NATURE MEDICINE

Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury

(2018) Enrico Velardi et al.   NATURE MEDICINE

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

(2018) Srinath C. Sampath et al.   Nature Communications

Quiescence status of glioblastoma stem-like cells involves remodelling of Ca2+ signalling and mitochondrial shape

(2018) Francisco J. Aulestia et al.   Scientific Reports

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone

(2018) Anna Engler et al.   Cell Reports

ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and Repopulation of Hematopoietic Stem Cells

(2018) Yu-feng Liu et al.   Stem Cell Reports

TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells

(2018) Xiaofang Wang et al.   Stem Cell Reports

Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool

(2018) Yi Zhou et al.   Cell Stem Cell

TRIM44 promotes quiescent multiple myeloma cell occupancy and survival in the osteoblastic niche via HIF-1α stabilization

(2018) Zheng Chen et al.   LEUKEMIA

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

(2018) Pablo Baquero et al.   LEUKEMIA

Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche

(2018) Meryem B. Baghdadi et al.   NATURE

Autophagy Is Indispensable for the Self-Renewal and Quiescence of Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties

(2018) Qian Wang et al.   Oxidative Medicine and Cellular Longevity

c-MPL Is a Candidate Surface Marker and Confers Self-Renewal, Quiescence, Chemotherapy Resistance, and Leukemia Initiation Potential in Leukemia Stem Cells

(2018) Huan Li et al.   STEM CELLS

The Intestinal Stem Cell Niche: Homeostasis and Adaptations

(2018) António J.M. Santos et al.   TRENDS IN CELL BIOLOGY

Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence

(2018) Meryem B. Baghdadi et al.   Cell Stem Cell

Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling

(2018) Mayank Verma et al.   Cell Stem Cell

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

(2018) Nai Yang Fu et al.   DEVELOPMENTAL CELL

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

CD150high CD4 T cells and CD150high Tregs regulate hematopoietic stem cell quiescence via CD73

(2018) Yuichi Hirata et al.   HAEMATOLOGICA

Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma

(2018) Tokuhiro Kimura et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells

(2018) Yasuo Kitajima et al.   Stem Cell Reports

Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL-AF9-Driven AML

(2018) Talia Velasco-Hernandez et al.   Stem Cell Reports

SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin

(2017) Yuan-Hung Lo et al.   GASTROENTEROLOGY

Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression

(2017) Eunsun Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone

(2017) Hiroki Kawai et al.   JOURNAL OF NEUROSCIENCE

Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia

(2017) S Fujita et al.   LEUKEMIA

Epigenetics in cancer stem cells

(2017) Tan Boon Toh et al.   Molecular Cancer

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Lactate dehydrogenase activity drives hair follicle stem cell activation

(2017) Aimee Flores et al.   NATURE CELL BIOLOGY

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

Differential cytokine contributions of perivascular haematopoietic stem cell niches

(2017) Noboru Asada et al.   NATURE CELL BIOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells

(2017) SiewHui Low et al.   STEM CELLS

Pten is necessary for the quiescence and maintenance of adult muscle stem cells

(2017) Feng Yue et al.   Nature Communications

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells

(2017) Aviva J. Goel et al.   Cell Reports

Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance

(2017) Fatih Semerci et al.   eLife

Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells

(2017) Chih-Li Lin et al.   Stem Cell Reports

Tumor microenvironment for cancer stem cells

(2016) Kazuyoshi Kise et al.   ADVANCED DRUG DELIVERY REVIEWS

Niche heterogeneity in the bone marrow

(2016) Alexander Birbrair et al.   Annals of the New York Academy of Sciences

The chromatin-associated Sin3B protein is required for hematopoietic stem cell functions in mice

(2016) David J. Cantor et al.   BLOOD

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

(2016) Eric R. Lechman et al.   CANCER CELL

Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma

(2016) Benita Wolf et al.   CANCER RESEARCH

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

(2016) Kevin A. Goncalves et al.   CELL

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Emerging concepts of epigenetic dysregulation in hematological malignancies

(2016) Panagiotis Ntziachristos et al.   NATURE IMMUNOLOGY

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway

(2016) Alicia M. McConnell et al.   Cell Reports

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

(2016) Wanyin Chen et al.   Stem Cells International

Melanoma dormancy in a mouse model is linked to GILZ/FOXO3A-dependent quiescence of disseminated stem-like cells

(2016) Yasmine Touil et al.   Scientific Reports

Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid

(2015) H. J. M. P. Verhagen et al.   BLOOD

TGF-  signaling in the control of hematopoietic stem cells

(2015) U. Blank et al.   BLOOD

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Recent insights into cell death and autophagy

(2015) Brent E. Fitzwalter et al.   FEBS Journal

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Osteoblastic niche supports the growth of quiescent multiple myeloma cells

(2014) Z. Chen et al.   BLOOD

Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis

(2014) Abel Sánchez-Aguilera et al.   Cell Stem Cell

Eosinophil Granule Proteins: Form and Function

(2014) K. Ravi Acharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

(2014) Daisuke Nakada et al.   NATURE

A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells

(2014) Jimena Andersen et al.   NEURON

Emerging Understanding of Multiscale Tumor Heterogeneity

(2014) Michael J. Gerdes et al.   Frontiers in Oncology

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Nrf2 regulates haematopoietic stem cell function

(2013) Jennifer J. Tsai et al.   NATURE CELL BIOLOGY

Molecular regulation of stem cell quiescence

(2013) Tom H. Cheung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer stem cells, microRNAs, and therapeutic strategies including natural products

(2012) Darshni Vira et al.   CANCER AND METASTASIS REVIEWS

VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression

(2012) Erzsebet Kokovay et al.   Cell Stem Cell

Neurogenic Subventricular Zone Stem/Progenitor Cells Are Notch1-Dependent in Their Active But Not Quiescent State

(2012) O. Basak et al.   JOURNAL OF NEUROSCIENCE

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis

(2011) Elaine Beaulieu et al.   Nature Reviews Rheumatology

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

(2011) Philippos Mourikis et al.   STEM CELLS

Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

(2011) Christopher R.R. Bjornson et al.   STEM CELLS

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

SED1/MFG-E8: A Bi-Motif protein that orchestrates diverse cellular interactions

(2009) Adam Raymond et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

TGF-  as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

(2008) S. Yamazaki et al.   BLOOD

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Cancer stem cells: implications for the progression and treatment of metastatic disease

(2008) A.K Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY