Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

(2017) Min Wei et al.   Science Translational Medicine

Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis

(2016) M. Noureddin et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

(2016) M. Borghesan et al.   CANCER RESEARCH

Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib

(2016) Gianluigi Mazzoccoli et al.   CURRENT DRUG TARGETS

Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma

(2016) Simone Jueliger et al.   Epigenetics

Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin-332/α3 integrin axis recovery of focal adhesion kinase ubiquitination

(2016) Amalia Azzariti et al.   HEPATOLOGY

Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis

(2016) Valerio Pazienza et al.   Epigenetics & Chromatin

Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

(2016) C. Vernieri et al.   Cancer Discovery

The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population

(2016) Daniele Balasus et al.   Oncotarget

SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

(2016) Valerio Pazienza et al.   Aging-US

Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies

(2016) Yalan Chen et al.   Scientific Reports

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Management strategies for hepatocellular carcinoma: old certainties and new realities

(2015) Gianluigi Mazzoccoli et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Pathophysiology of Liver Fibrosis

(2015) Massimo Pinzani   DIGESTIVE DISEASES

Low cytochrome oxidase 4I1 links mitochondrial dysfunction to obesity and type 2 diabetes in humans and mice

(2015) B Van der Schueren et al.   INTERNATIONAL JOURNAL OF OBESITY

Designing a broad-spectrum integrative approach for cancer prevention and treatment

(2015) Keith I. Block et al.   SEMINARS IN CANCER BIOLOGY

Epidemiology of Hepatocellular Carcinoma

(2015) Kelly J. Lafaro et al.   Surgical Oncology Clinics of North America

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

(2015) Giovanna Bianchi et al.   Oncotarget

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

(2015) Irene Caffa et al.   Oncotarget

LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease

(2015) Sara Ceccarelli et al.   Oncotarget

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis

(2015) Chad McKee et al.   Scientific Reports

Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis

(2015) Kosuke Saito et al.   Scientific Reports

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing

(2015) Valentina Tesori et al.   Scientific Reports

Hepatocellular carcinoma epidemiology

(2014) Cristina Bosetti et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Protein intake, chronic liver diseases, and hepatocellular carcinoma

(2014) Manlio Vinciguerra   HEPATOLOGY

IL-17A Enhances the Expression of Profibrotic Genes through Upregulation of the TGF-β Receptor on Hepatic Stellate Cells in a JNK-Dependent Manner

(2014) Thomas Fabre et al.   JOURNAL OF IMMUNOLOGY

microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

LINE-1 Hypomethylation in Blood and Tissue Samples as an Epigenetic Marker for Cancer Risk: A Systematic Review and Meta-Analysis

(2014) Martina Barchitta et al.   PLoS One

Roles of Caloric Restriction, Ketogenic Diet and Intermittent Fasting during Initiation, Progression and Metastasis of Cancer in Animal Models: A Systematic Review and Meta-Analysis

(2014) Mengmeng Lv et al.   PLoS One

Liver diseases and aging: friends or foes?

(2013) Fareeba Sheedfar et al.   AGING CELL

Redox Homeostasis and Epigenetics in Non-alcoholic Fatty Liver Disease (NAFLD)

(2013) Christine Podrini et al.   CURRENT PHARMACEUTICAL DESIGN

Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma

(2013) Francesca Rappa et al.   PLoS One

Molecular mechanisms of sorafenib action in liver cancer cells

(2012) Melchiorre Cervello et al.   CELL CYCLE

DNA Methyltransferases 1 and 3b Expression in Huh-7 Cells Expressing HCV Core Protein of Different Genotypes

(2012) Giorgia Benegiamo et al.   DIGESTIVE DISEASES AND SCIENCES

Expression of Septin4 in Human Hepatic Stellate Cells LX-2 Stimulated by LPS

(2012) Xiaolei Sun et al.   INFLAMMATION

Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy

(2012) Fernando Safdie et al.   PLoS One

HGF and Direct Mesenchymal Stem Cells Contact Synergize to Inhibit Hepatic Stellate Cells Activation through TLR4/NF-kB Pathway

(2012) Pei-pei Wang et al.   PLoS One

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

(2012) C. Lee et al.   Science Translational Medicine

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats

(2010) Cheng Liu et al.   LABORATORY INVESTIGATION

The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue

(2009) Christelle Veyrat-Durebex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Experimental mouse models for hepatocellular carcinoma research

(2009) Femke Heindryckx et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

PTEN Down-Regulation by Unsaturated Fatty Acids Triggers Hepatic Steatosis via an NF-κBp65/mTOR-Dependent Mechanism

(2007) Manlio Vinciguerra et al.   GASTROENTEROLOGY