Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

(2019) Charlène Niogret et al.   Nature Communications

Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation

(2018) Wei-Qiang Jia et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Natural killer cell cytotoxicity and its regulation by inhibitory receptors

(2018) Santosh Kumar   IMMUNOLOGY

CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity

(2018) Amelia Roman Aguilera et al.   OncoImmunology

TIGIT: a novel immunotherapy target moving from bench to bedside

(2018) Benjamin L. Solomon et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Translating the anti-myeloma activity of Natural Killer cells into clinical application

(2018) Cinzia Fionda et al.   CANCER TREATMENT REVIEWS

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

(2018) Monica Parodi et al.   Frontiers in Immunology

Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients

(2018) Hansol Lee et al.   OncoImmunology

Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy

(2017) Tzu-Ting Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming

(2017) Julia A. Wagner, Maximillian Rosario, Rizwan Romee, Melissa M. Berrien-Elliott, Stephanie E. Schneider, Jeffrey W. Leong, Ryan P. Sullivan, Brea A. Jewell, Michelle Becker-Hapak, Timothy Schappe, Sara Abdel-Latif, Aaron R. Ireland, Devika Jaishankar, Justin A. King, Ravi Vij, Dennis Clement, Jodie Goodridge, Karl-Johan Malmberg, Hing C. Wong, Todd A. Fehniger   JOURNAL OF CLINICAL INVESTIGATION

Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

(2017) Zachary B. Davis et al.   SEMINARS IN IMMUNOLOGY

Natural Killer Cell-Based Cancer Immunotherapies: From Immune Evasion to Promising Targeted Cellular Therapies

(2017) Erhard Hofer et al.   Frontiers in Immunology

The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

(2017) Sourav Paul et al.   Frontiers in Immunology

Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities

(2016) Sonia Y. Velásquez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Regulation of Natural Killer Cell Function by STAT3

(2016) Nicholas A. Cacalano   Frontiers in Immunology

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

(2015) J. Benito et al.   CLINICAL CANCER RESEARCH

Targeting Tumor Hypoxia With Hypoxia-Activated Prodrugs

(2015) Jen Jen Yeh et al.   JOURNAL OF CLINICAL ONCOLOGY

Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress

(2015) Meriem Hasmim et al.   Frontiers in Immunology

Mechanisms of Hypoxia-Mediated Immune Escape in Cancer

(2014) I. B. Barsoum et al.   CANCER RESEARCH

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

(2014) Charlotte Viant et al.   Nature Communications

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

(2013) A. M. James et al.   BLOOD

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

(2013) A. Mazharian et al.   BLOOD

Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC

(2013) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Membrane-bound TRAIL Supplements Natural Killer Cell Cytotoxicity Against Neuroblastoma Cells

(2013) Michael A. Sheard et al.   JOURNAL OF IMMUNOTHERAPY

Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

(2013) Subhashis Sarkar et al.   PLoS One

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection

(2013) Joachim Koch et al.   TRENDS IN IMMUNOLOGY

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models

(2012) J. Hu et al.   Disease Models & Mechanisms

Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells

(2011) Thushara P. Abeyweera et al.   JOURNAL OF CELL BIOLOGY

Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug

(2010) J. Hu et al.   BLOOD

Activating and inhibitory receptors of natural killer cells

(2010) Hollie J Pegram et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulation of human NK-cell cytokine and chemokine production by target cell recognition

(2009) C. Fauriat et al.   BLOOD

SHP-2 Expression Negatively Regulates NK Cell Function

(2009) A. K. Purdy et al.   JOURNAL OF IMMUNOLOGY