Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

(2016) Bernhard Mlecnik et al.   IMMUNITY

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

(2016) Bernhard Mlecnik et al.   Science Translational Medicine

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

(2015) Vincent-Philippe Lavallée et al.   NATURE GENETICS

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Immunoproteasome Function in the Lung

(2015) Ilona E. Keller et al.   Scientific Reports

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations

(2014) Vincent-Philippe Lavallée et al.   BLOOD

The Immunoproteasome as a Therapeutic Target for Hematological Malignancies

(2014) Zachary Miller et al.   CURRENT CANCER DRUG TARGETS

Emerging therapies targeting the ubiquitin proteasome system in cancer

(2014) Nathaniel M. Weathington et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunoproteasomes Shape the Transcriptome and Regulate the Function of Dendritic Cells

(2014) D. A. de Verteuil et al.   JOURNAL OF IMMUNOLOGY

The Proto-MHC of Placozoans, a Region Specialized in Cellular Stress and Ubiquitination/Proteasome Pathways

(2014) Jaanus Suurväli et al.   JOURNAL OF IMMUNOLOGY

Structure-Based Design of β1i or β5i Specific Inhibitors of Human Immunoproteasomes

(2014) Gerjan de Bruin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immunoproteasome in animal models of Duchenne muscular dystrophy

(2014) Chiao-nan Joyce Chen et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Acquired and intrinsic resistance in cancer immunotherapy

(2014) Sander Kelderman et al.   Molecular Oncology

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

A comprehensive transcriptional portrait of human cancer cell lines

(2014) Christiaan Klijn et al.   NATURE BIOTECHNOLOGY

OrthoClust: an orthology-based network framework for clustering data across multiple species

(2014) Koon-Kiu Yan et al.   GENOME BIOLOGY

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

(2014) Nico P. Dantuma et al.   Frontiers in Molecular Neuroscience

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Tumor-Infiltrating Lymphocytes Expressing the Tissue Resident Memory Marker CD103 Are Associated with Increased Survival in High-Grade Serous Ovarian Cancer

(2013) J. R. Webb et al.   CLINICAL CANCER RESEARCH

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia

(2013) Guilherme Augusto dos Santos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma

(2013) X Wang et al.   LEUKEMIA

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

The immunoproteasome in antigen processing and other immunological functions

(2012) Michael Basler et al.   CURRENT OPINION IN IMMUNOLOGY

What shall we do with the damaged proteins in lung disease? Ask the proteasome!

(2012) Silke Meiners et al.   EUROPEAN RESPIRATORY JOURNAL

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Analysis of the Processing of Seven Human Tumor Antigens by Intermediate Proteasomes

(2012) B. Guillaume et al.   JOURNAL OF IMMUNOLOGY

Molecular Mechanisms of Acquired Proteasome Inhibitor Resistance

(2012) Andrew J. Kale et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Protein degradation and the stress response

(2012) Karin Flick et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Putative Role for the Immunoproteasome in the Maintenance of Pluripotency in Human Embryonic Stem Cells

(2012) Stuart P. Atkinson et al.   STEM CELLS

Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates

(2011) W. H. Fridman et al.   CANCER RESEARCH

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

(2011) Caterina Bendotti et al.   PROGRESS IN NEUROBIOLOGY

Deletion of Immunoproteasome Subunits Imprints on the Transcriptome and Has a Broad Impact on Peptides Presented by Major Histocompatibility Complex I molecules

(2010) Danielle de Verteuil et al.   MOLECULAR & CELLULAR PROTEOMICS

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

(2010) B. Guillaume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress affects processing of MHC class I-associated peptides

(2009) Diana P Granados et al.   BMC IMMUNOLOGY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Selective Accumulation of Aggregation-Prone Proteasome Substrates in Response to Proteotoxic Stress

(2009) F. A. Salomons et al.   MOLECULAR AND CELLULAR BIOLOGY

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Modeling the in Vitro 20S Proteasome Activity: The Effect of PA28–αβ and of the Sequence and Length of Polypeptides on the Degradation Kinetics

(2008) Michele Mishto et al.   JOURNAL OF MOLECULAR BIOLOGY