Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

(2020) Christopher B. Driscoll et al.   Nature Communications

MR Imaging Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer

(2020) Tiril Hillestad et al.   CANCER RESEARCH

Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer

(2020) Samuel B. Bader et al.   Cancers

Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases

(2019) Joseph C F Ng et al.   NUCLEIC ACIDS RESEARCH

Volumetric optoacoustic imaging unveils high-resolution patterns of acute and cyclic hypoxia in a murine model of breast cancer

(2019) Avihai Ron et al.   CANCER RESEARCH

Guidelines for using sigQC for systematic evaluation of gene signatures

(2019) Andrew Dhawan et al.   Nature Protocols

Before and After: Comparison of Legacy and Harmonized TCGA Genomic Data Commons’ Data

(2019) Galen F. Gao et al.   Cell Systems

Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression

(2019) Saxena et al.   Biomolecules

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

(2019) Artur A. Serebrenik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI

(2018) James O'Connor et al.   BRITISH JOURNAL OF RADIOLOGY

The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53

(2017) Daniel Menendez et al.   MOLECULAR CANCER RESEARCH

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

(2017) Iosifina P. Foskolou et al.   MOLECULAR CELL

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

(2017) Luis Toledo et al.   MOLECULAR CELL

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

(2017) Manikandan Periyasamy et al.   NUCLEIC ACIDS RESEARCH

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

(2016) Vladimir B. Seplyarskiy et al.   GENOME RESEARCH

Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes

(2016) Shraddha Sharma et al.   RNA Biology

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

(2016) James I. Hoopes et al.   Cell Reports

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

(2016) E. K. Law et al.   Science Advances

The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme

(2016) Shraddha Sharma et al.   Scientific Reports

The PKC/NF-κB Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers

(2015) Brandon Leonard et al.   CANCER RESEARCH

Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT

(2015) Katarzyna B. Leszczynska et al.   JOURNAL OF CLINICAL INVESTIGATION

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms

(2015) C. King et al.   MOLECULAR CANCER THERAPEUTICS

APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

(2015) Shraddha Sharma et al.   Nature Communications

APOBEC3B: Pathological consequences of an innate immune DNA mutator

(2015) ReubenS Harris et al.   Biomedical Journal

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic

(2013) Allison M. Land et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

(2013) Monica M. Olcina et al.   MOLECULAR CELL

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging hypoxia to improve radiotherapy outcome

(2012) Michael R. Horsman et al.   Nature Reviews Clinical Oncology

Functions and regulation of the APOBEC family of proteins

(2011) Harold C. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

(2010) F M Buffa et al.   BRITISH JOURNAL OF CANCER

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

(2010) I. M. Pires et al.   CANCER RESEARCH

Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice

(2010) H. Yasui et al.   CANCER RESEARCH

Imaging Cycling Tumor Hypoxia

(2010) S. Matsumoto et al.   CANCER RESEARCH

Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1

(2010) Isabel M. Pires et al.   CELL CYCLE

Mechanism of Hypoxia-Induced NF- B

(2010) C. Culver et al.   MOLECULAR AND CELLULAR BIOLOGY

Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets

(2009) F. A. Koning et al.   JOURNAL OF VIROLOGY

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress

(2009) Mark W. Dewhirst   RADIATION RESEARCH

Reproducibility of Intratumor Distribution of 18F-Fluoromisonidazole in Head and Neck Cancer

(2008) Sadek A. Nehmeh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

ATM Activation and Signaling under Hypoxic Conditions

(2008) Z. Bencokova et al.   MOLECULAR AND CELLULAR BIOLOGY