Overcoming hypoxia-induced functional suppression of NK cells

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

(2019) Fernando Souza-Fonseca-Guimaraes et al.   TRENDS IN IMMUNOLOGY

Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell carcinoma cells by high-affinity natural killer cells

(2019) Jay Friedman et al.   ORAL ONCOLOGY

NANT cancer vaccine an orchestration of immunogenic cell death by overcoming immune suppression and activating NK and T cell therapy in patients with third line or greater metastatic pancreatic cancer.

(2019) Tara Elisabeth Seery et al.   JOURNAL OF CLINICAL ONCOLOGY

NKG2D: A Master Regulator of Immune Cell Responsiveness

(2018) Felix M. Wensveen et al.   Frontiers in Immunology

The Neutrophil’s Choice: Phagocytose vs Make Neutrophil Extracellular Traps

(2018) Angelo A. Manfredi et al.   Frontiers in Immunology

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

(2018) Jay Friedman et al.   Journal for ImmunoTherapy of Cancer

Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition

(2018) Kathleen E. Fenerty et al.   Journal for ImmunoTherapy of Cancer

ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody

(2017) Caroline Jochems et al.   INTERNATIONAL JOURNAL OF CANCER

The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

(2017) Sourav Paul et al.   Frontiers in Immunology

The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer

(2016) Sylvain Ladoire et al.   Autophagy

STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer

(2016) YAO CUI et al.   ONCOLOGY REPORTS

Intratumoral oxygen gradients mediate sarcoma cell invasion

(2016) Daniel M. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele

(2016) Caroline Jochems et al.   Oncotarget

Regulation of Natural Killer Cell Function by STAT3

(2016) Nicholas A. Cacalano   Frontiers in Immunology

High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer

(2016) Cheng Sun et al.   OncoImmunology

Ghrelin Inhibits the Differentiation of T Helper 17 Cells through mTOR/STAT3 Signaling Pathway

(2015) Yanhui Xu et al.   PLoS One

Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer

(2015) Christine Pasero et al.   Oncotarget

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2014) Joseph C. Walsh et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance

(2014) D. Gotthardt et al.   BLOOD

Perforin: an important player in immune response

(2014) Iwona Osińska et al.   Central European Journal of Immunology

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

(2013) K. Krzewski et al.   BLOOD

Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage

(2013) A. Cohnen et al.   BLOOD

Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC

(2013) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Application of Selected Reaction Monitoring for Multiplex Quantification of Clinically Validated Biomarkers in Formalin-Fixed, Paraffin-Embedded Tumor Tissue

(2013) Todd Hembrough et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells

(2013) M R Pawlus et al.   ONCOGENE

Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

(2013) Subhashis Sarkar et al.   PLoS One

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Human NKG2D-ligands: cell biology strategies to ensure immune recognition

(2012) Lola Fernández-Messina et al.   Frontiers in Immunology

Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

(2011) S. Platonova et al.   CANCER RESEARCH

STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination

(2009) Joo Eun Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hypoxia in prostate cancer: A powerful shield against tumour destruction?

(2008) L. Marignol et al.   CANCER TREATMENT REVIEWS