Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

(2021) Ke Xu et al.   SCIENCE

Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion

(2021) Annelise Y. Mah-Som et al.   Cell Reports

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity

(2020) Dalton Hermans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

(2020) Nobu Oshima et al.   Cell Reports

Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells

(2020) Garvin Dodard et al.   Cell Reports

Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells

(2019) Nicholas M. Adams et al.   IMMUNITY

Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection

(2019) Simon Grassmann et al.   IMMUNITY

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc

(2019) Han Dong et al.   NATURE IMMUNOLOGY

Activation Receptor–Dependent IFN-γ Production by NK Cells Is Controlled by Transcription, Translation, and the Proteasome

(2019) Sytse J. Piersma et al.   JOURNAL OF IMMUNOLOGY

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

(2018) Róisín M. Loftus et al.   Nature Communications

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Four Key Steps Control Glycolytic Flux in Mammalian Cells

(2018) Lukas Bahati Tanner et al.   Cell Systems

Epigenetic control of innate and adaptive immune memory

(2018) Colleen M. Lau et al.   NATURE IMMUNOLOGY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

(2017) Ken Peeters et al.   Nature Communications

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells

(2016) Sinéad E. Keating et al.   JOURNAL OF IMMUNOLOGY

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Cutting Edge: Stage-Specific Requirement of IL-18 for Antiviral NK Cell Expansion

(2015) Sharline Madera et al.   JOURNAL OF IMMUNOLOGY

Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production

(2015) Molly P. Keppel et al.   JOURNAL OF IMMUNOLOGY

Regulation of mammalian nucleotide metabolism and biosynthesis

(2015) Andrew N. Lane et al.   NUCLEIC ACIDS RESEARCH

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Ly49h-Deficient C57BL/6 Mice: A New Mouse Cytomegalovirus-Susceptible Model Remains Resistant to Unrelated Pathogens Controlled by the NK Gene Complex

(2014) N. Fodil-Cornu et al.   JOURNAL OF IMMUNOLOGY

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

(2014) Raymond P. Donnelly et al.   JOURNAL OF IMMUNOLOGY

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Proinflammatory cytokine signaling required for the generation of natural killer cell memory

(2012) Joseph C. Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

2-Deoxy D-Glucose Prevents Cell Surface Expression of NKG2D Ligands through Inhibition of N-Linked Glycosylation

(2012) L. Andresen et al.   JOURNAL OF IMMUNOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

(2011) Anna N. Mendler et al.   INTERNATIONAL JOURNAL OF CANCER

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor

(2011) E. Narni-Mancinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism

(2010) Mauro Sola-Penna et al.   IUBMB LIFE

Evolution of Allosteric Citrate Binding Sites on 6-phosphofructo-1-kinase

(2010) Aleksandra Usenik et al.   PLoS One

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

New insights into the regulation and function of serine/threonine kinases in T lymphocytes

(2009) Sharon A. Matthews et al.   IMMUNOLOGICAL REVIEWS

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Continuous engagement of a self-specific activation receptor induces NK cell tolerance

(2008) Sandeep K. Tripathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

(2008) D. Zhong et al.   MOLECULAR CANCER THERAPEUTICS