Glycans as Key Checkpoints of T Cell Activity and Function

Skeletal muscle cells actively shape (auto)immune responses

(2018) Ali Maisam Afzali et al.   AUTOIMMUNITY REVIEWS

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

(2018) Chia-Wei Li et al.   CANCER CELL

Interleukin-10 Directly Inhibits CD8 + T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity

(2018) Logan K. Smith et al.   IMMUNITY

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Risk factors and disease mechanisms in myositis

(2018) Frederick W. Miller et al.   Nature Reviews Rheumatology

Metabolic control of T cell immune response through glycans in inflammatory bowel disease

(2018) Ana M. Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(2018) Michal A. Stanczak et al.   JOURNAL OF CLINICAL INVESTIGATION

Lectin-binding characterizes the healthy human skeletal muscle glycophenotype and identifies disease-specific changes in dystrophic muscle

(2017) Brian J McMorran et al.   GLYCOBIOLOGY

T Cell Development by the Numbers

(2017) Andreas Krueger et al.   TRENDS IN IMMUNOLOGY

The Mechanisms of T Cell Selection in the Thymus

(2017) Hiroyuki Takaba et al.   TRENDS IN IMMUNOLOGY

Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery

(2017) Tiago Clemente et al.   Cell Death & Disease

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

(2017) Masahiro Okada et al.   Cell Reports

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

(2017) Lindsey Araujo et al.   eLife

Functions of galectins as ‘self/non-self’-recognition and effector factors

(2017) Gerardo R. Vasta et al.   Pathogens and Disease

Distinctive Surface Glycosylation Patterns Associated With Mouse and Human CD4+ Regulatory T Cells and Their Suppressive Function

(2017) Joana Cabral et al.   Frontiers in Immunology

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease

(2016) Emil R. Unanue et al.   Annual Review of Immunology

Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease

(2016) Hironobu Fujii et al.   GASTROENTEROLOGY

Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx

(2016) Brian J McMorran et al.   GLYCOBIOLOGY

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

(2016) Richard Beatson et al.   NATURE IMMUNOLOGY

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

(2016) Maurizio Perdicchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic pathways in T cell activation and lineage differentiation

(2016) Luís Almeida et al.   SEMINARS IN IMMUNOLOGY

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

(2016) Maurizio Perdicchio et al.   Oncotarget

Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis

(2016) Haik Mkhikian et al.   eLife

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways

(2016) Michael C. Ryczko et al.   Scientific Reports

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

(2015) Bruce S. Bochner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: A critical review

(2015) Emanual Maverakis et al.   JOURNAL OF AUTOIMMUNITY

Glucosamine Modulates T Cell Differentiation through Down-regulatingN-Linked Glycosylation of CD25

(2015) Ming-Wei Chien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development

(2015) Yinghui Song et al.   JOURNAL OF IMMUNOLOGY

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

(2015) Amine Boudil et al.   NATURE IMMUNOLOGY

Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

(2015) Chiao-Wen Kang et al.   Scientific Reports

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

(2015) T. Kouo et al.   Cancer Immunology Research

Finding the Sweet Spot: Assembly and Glycosylation of the Dystrophin-Associated Glycoprotein Complex

(2014) Dewayne Townsend   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Minireview Series on the Thirtieth Anniversary of Research onO-GlcNAcylation of Nuclear and Cytoplasmic Proteins: Nutrient Regulation of Cellular Metabolism and Physiology byO-GlcNAcylation

(2014) Gerald W. Hart   JOURNAL OF BIOLOGICAL CHEMISTRY

CNS myelin induces regulatory functions of DC-SIGN–expressing, antigen-presenting cells via cognate interaction with MOG

(2014) J.J. García-Vallejo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Overview of the Intrathymic Intricacies of T Cell Development

(2014) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry

(2014) Lei Zhu et al.   mAbs

Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells

(2014) Mylène A. Carrascal et al.   Molecular Oncology

N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca2+ signaling

(2014) Raymond W Zhou et al.   NATURE IMMUNOLOGY

Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

(2014) Sonja I. Gringhuis et al.   Nature Communications

Probing the Hexosamine Biosynthetic Pathway in Human Tumor Cells by Multitargeted Tandem Mass Spectrometry

(2013) Anas M. Abdel Rahman et al.   ACS Chemical Biology

Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis

(2013) Ana M. Dias et al.   HUMAN MOLECULAR GENETICS

Secretory IgA Induces Tolerogenic Dendritic Cells through SIGNR1 Dampening Autoimmunity in Mice

(2013) J. Diana et al.   JOURNAL OF IMMUNOLOGY

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion

(2013) Sandra J. van Vliet et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants

(2013) Carey F. Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Adaptive immune activation: glycosylation does matter

(2013) Margreet A Wolfert et al.   Nature Chemical Biology

The regulatory power of glycans and their binding partners in immunity

(2013) Jenny L. Johnson et al.   TRENDS IN IMMUNOLOGY

NETs: the missing link between cell death and systemic autoimmune diseases?

(2013) Erika Darrah et al.   Frontiers in Immunology

T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival

(2012) Mary C. Clark et al.   Annals of the New York Academy of Sciences

Glycobiology of immune responses

(2012) Gabriel A. Rabinovich et al.   Annals of the New York Academy of Sciences

Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner

(2012) Souichi Oomizu et al.   CLINICAL IMMUNOLOGY

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

(2012) Wendy W.J. Unger et al.   JOURNAL OF CONTROLLED RELEASE

Expression of Functional P-Selectin Glycoprotein Ligand 1 on Hematopoietic Progenitors Is Developmentally Regulated

(2012) D. A. Sultana et al.   JOURNAL OF IMMUNOLOGY

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

A two-way street: reciprocal regulation of metabolism and signalling

(2012) Kathryn E. Wellen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation

(2012) Ani Grigorian et al.   Seminars in Immunopathology

The integration of signaling and the spatial organization of the T cell synapse

(2012) Jérémie Rossy et al.   Frontiers in Immunology

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again

(2011) Santiago Di Lella et al.   BIOCHEMISTRY

N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses and Treats Experimental Autoimmune Encephalomyelitis

(2011) Ani Grigorian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MHCII glycosylation modulatesBacteroides fragiliscarbohydrate antigen presentation

(2011) Sean O. Ryan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis

(2011) Haik Mkhikian et al.   Nature Communications

Galectin-9 regulates T helper cell function independently of Tim-3

(2010) E. W. Su et al.   GLYCOBIOLOGY

Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization

(2010) Han-Yu Shih et al.   IMMUNOLOGIC RESEARCH

Lunatic Fringe Enhances Competition for Delta-Like Notch Ligands but Does Not Overcome Defective Pre-TCR Signaling during Thymocyte  -Selection In Vivo

(2010) I. Visan et al.   JOURNAL OF IMMUNOLOGY

MGAT5 alters the severity of multiple sclerosis

(2010) B. Brynedal et al.   JOURNAL OF NEUROIMMUNOLOGY

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

(2010) M. N. Artyomov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialic acids in T cell development and function

(2009) Shuguang Bi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Increasing functional avidity of TCR-redirected T cells by removing definedN-glycosylation sites in the TCR constant domain

(2009) Jürgen Kuball et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

Prophylactic treatment with sialic acid metabolites precludes the development of the myopathic phenotype in the DMRV-hIBM mouse model

(2009) May Christine V Malicdan et al.   NATURE MEDICINE

Adaptive Regulation at the Cell Surface byN-Glycosylation

(2009) James W. Dennis et al.   TRAFFIC

Disruption of thymopoiesis in ST6Gal I-deficient mice

(2008) J. H Marino et al.   GLYCOBIOLOGY

Alteration ofN-glycosylation in the kidney in a mouse model of systemic lupus erythematosus: relative quantification ofN-glycans using an isotope-tagging method

(2008) Noritaka Hashii et al.   IMMUNOLOGY

O-LinkedN-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors

(2008) Aiko Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-glycan interactions in the control of innate and adaptive immune responses

(2008) Yvette van Kooyk et al.   NATURE IMMUNOLOGY